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DOI: 10.18413/2658-6533-2019-5-2-0-5

Development of the composition, production technology, biological studies of medicinal syrup with ethylmethylhydroxypyridine succinate for the prevention and treatment of hypoxic conditions

Background: Both the dosage form and the complex of auxiliary substances are important pharmaceutical factors determining the final pharmacological effect. It is important to carefully select different groups of auxiliary substances in the design of drugs, providing a combination of convenience, comfort of treatment and administration. Syrup as a liquid dosage form is no exception to the rule. The list of syrups with antioxidants and antihypoxants is limited. The domestic developments include just a syrup with lipoxinol (sodium poly (dihydroxyphenyl) thiosulfonate (K.I. Maksimenkova, 2017). The aim of the study:Technological research on the development of the composition and technology of medicinal syrup with ethylmethylhydroxypyridine succinate, as well as the assessment of its biological activity. Materials and methods: Medicinal syrups were prepared by boiling in a syrup boiler. Quality assessment was carried out according to GPh XIII, pH determination potentiometrically using a desktop pH meter of Hanna Instruments with automatic calibration; density was assessed with a pycnometer. Antioxidant, membrane-stabilizing activity of the developed syrups was studied using the method on Paramecia. Results: Syrups with mexidol (ethylmethylhydroxypyridine succinate) based on sorbitol and fructose were developed. Technological and biological researches of the developed dosage form were carried out. Syrup with Mexidol is a homogeneous viscous liquid of raspberry and cherry color with a sour taste, pH 4.9-5.1, density 1.23-25. The amount of ethyl methyl hydroxypyridine succinate in the syrup should be from 12.0 to 13.0 g per 100 g. Biological studies on Paramecia confirmed the presence of the antioxidant and membrane stabilizing activity of the developed liquid dosage form. Conclusion: Experiments on Paramecia have confirmed the presence of antioxidant and membrane stabilizing activity, which may suggest antihypoxant and neurotropic activity

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