Effect of IL10 (rs1800872) and CXCL10 (rs4386624, rs4256246) genes polymorphism in the development of viral and bacterial infectious diseases
Background: Host-pathogenic interaction is a necessary but not sufficient precondition for the development of the disease. The immune response to the introduction of pathogen is largely controlled by genetic factors, whose study is relevant because infectious diseases, such as tuberculosis (TB) and chronic viral hepatitis C (HCV) are highly prevalent in the world. The aim of the study: To study the associations of polymorphic variants of the IL10 (rs1800872) and CXCL10 (rs4386624, rs4256246) genes of the anti-infectious immune response in the development of infectious diseases of various etiologies. Materials and methods: Genotyping was performed in patients with pulmonary tuberculosis (n = 304), viral hepatitis C (n = 184) and relatively healthy individuals (n = 255) by real-time PCR using TaqMan probes and restriction analysis. The associations were evaluated using the χ2 test or the Fisher's exact test. The significance threshold was set at p<0.05. Results: The polymorphism of genes IL10 (rs1800872) and CXCL10 (rs4256264) is associated with infectious diseases of various etiologies. The “AC” and “AA” genotypes of the IL10 gene (rs1800872) are “adverse” to the induction of the immune response to the effects of mycobacterium tuberculosis and the hepatitis C virus. The frequency of these genotypes is higher in patients (HCV – 43.1%, p = 0.033; TB – 44.0% p = 0.013) compared with the control (32.2%). The “AG” and “GG” genotypes of the CXCL10 gene (rs4256264) are also associated with infectious diseases and are more common in the patients (HCV – 100%, p = 0.0079; TB – 99.3%, p = 0.023) compared with control (96.2%). Conclusion: Functionally significant polymorphisms in the IL10 (rs1800872) and CXCL10 (rs4256264) genes are promising prognostic markers of deficiency of the immune response to infection of bacterial and viral etiology.
Goncharova IA, Bragina EYu, Zhalsanova IZ, et al. Effect of IL10 (rs1800872) and CXCL10 (rs4386624, rs4256246) genes polymorphism in the development of viral and bacterial infectious diseases. Research Results in Biomedicine.2019;5(4):32-43. (In Russian) DOI: 10.18413/2658-6533-2019-5-4-0-3
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The work was carried out as part of the implementation of the State task of the Ministry of Science and Higher Education N 075-00603-19-00 (Research Institute of Medical Genetics, Tomsk National Research Center).