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DOI: 10.18413/2313-8955-2015-1-4-62-65

MORPHOMETRIC STUDY OF HIPPOCAMPAL NEURONS IN CHRONIC IMMOBILIZATION STRESS

Hippocampus provides the implementation of the memory mechanisms, behavioral reactions, including avoidance of stress, aversive effects ect. The study was performed on the material of 20 male Wistar rats weighing 220-250 g, 10 of which were intact control group and 10 were experimental group in which simulated chronic immobilization stress. It was determined that the relative number of neurons in multiple fields of view on the total area of the pyramidal and polymorphic layers CA1 and CA3 regions, larger and smaller diameters of neuron’s bodies, their perimeters and areas with diameters of nuclei and nucleoli, nuclear-cytoplasmic ratio. It is found that the chronic immobilization stress in areas CA1 and CA3 of the hippocampus observed morphologically similar neuronal lesions, decrease in their number, changing nucleocytoplasmic ratio.

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