THE STRUCTURAL AND FUNCTIONAL STATUS OF THE BONE IN YOUNG PEOPLE WITH OSTEOARTHRITIS DEPENDING ON THE LEVEL OF PLASMA APELIN AND POLYMORPHISM OF THE LACTASE GENE
The authors carried out a detailed study of the influence of the plasmatic levels of apelin-13 on the development of structural and functional disorders condition of the bone tissue in patients with osteoarthritis (OA), depending on different versions of the polymorphism of the lactase gene (LCT). In a comprehensive study of 96 patients with OA, the authors revealed that among all patients participating in the study, the dominant group is composed of those with heterozygous genotype CT and homozygous CC, the frequency of which was found significantly higher than in patients with genotype TT (respectively, 50%, 40,6% and 9.3%, p<0.05). It was found that patients with OA with oligomorphic variant prevailed (more than 10-fold, p<0.001) over the individuals with genotype TT. The study has proved the impact of polymorphism of the LCT gene variability in the levels of plasmatic concentrations of apelin: the polymorphism CC variant is the most unfavorable for the development of osteoporosis (76.8% of patients had impaired bone density). Therefore, the authors state that the possible metabolic individuality of these patients (homozygous CC) is a relative decrease in the concentrations of plasmatic apelin on the background of the formation of osteopenic states.
Tereshkin KI, Tereshkina OI. Strukturno-funktsional'noe sostoyanie kostnoy tkani u lits molodogo vozrasta s osteoartrozom v zavisimosti ot urovnya plazmaticheskogo apelina i polimorfizma gena laktazy [The structural and functional status of the bone in young people with osteoarthritis depending on the level of plasma apelin and polymorphism of the lactase gene] // Research Result. Medicine and Pharmacy. 2017;3(1):3-7.
https://doi.org/10.18413/2313-8955-2017-3-1-3-7
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