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Research Results in Biomedicine

Volume 6, Issue №1, 2020 PDF
Genetics

New data collection priority: focusing on genome-based bioinformation

Genetic research used to be data-driven under the framework of well-established gene theory. With the advance of various-omics technologies, large-scale data generation has become routine. However, data analyses ...

Contribution of rs11927381 polymorphism of the IGF2BP2 gene to the pathogenesis of type 2 diabetes

Background: Pancreatic beta-cell dysfunction, along with the insulin resistance of peripheral tissues, is a key element in the pathogenesis of type 2 diabetes (T2D). In this regard, of ...

The role of polymorphic variants of the contactin-associated-like protein-2 (CNTNAP2) gene in the formation of differences in anxiety levels

Background: The study of the multifactor nature of anxiety is caused by its role in multiple aspects of human development including physical and mental health, emotional sphere and ...

The study of the association of polymorphic loci of the folate cycle genes with the development of the 2-3-degree fetal growth restriction syndrome
 

Background: Folate cycle enzymes regulate key reactions in folate-mediated single-carbon metabolism. The folate cycle disturbances may be associated with the occurrence of placental insufficiency with fetal growth restriction ...

ZNF804A rs1344706 gene polymorphism and clinical heterogeneity of schizophrenia
 

Background: Replication of genome-wide association study (GWAS) loci for schizophrenia in different populations as well as the study of their specificity for disease are important issues in searching ...

The contribution of gene-gene interactions of polymorphic loci of matrix metalloproteinases to susceptibility to primary open-angle glaucoma in men
 

Background: Primary open-angle glaucoma (POAG) is a serious form of eye diseases leading to blindness and disability. Glaucoma in men occurs in more than half of cases (65%). ...
Pharmacology

Pharmacological effects of the combined administration of a small dose of Acetylsalicylic acid and methyldopa in ADMA-like preeclampsia
 

Background: Hypertensive disorders, in particular preeclampsia, which accounts for 2 to 8% of the total number of pregnancies in the world, are one of the leading causes of ...
Medicine (miscellaneous)

Features of the species composition and functional activity of mast cells in the decidual tissue of patients with undeveloped pregnancy and polycystic ovary syndrome
 

Background: Infertility, miscarriage, birth of full-term healthy children take dominant positions among the problems of obstetrics and gynecology. Рolycystic ovary syndrome is a disease one of the clinical manifestations ...

Interrelation of interleukin profile and the blood oxidant system in elderly patients with late-stage age-related macular degeneration
 

Background: In the elderly, age-related macular degeneration has a high prevalence and often causes a decrease and complete loss of vision. However, immunological mechanisms of development of this ...

Association of lipid and carbohydrate metabolism disorders with blood pressure indicators in the morning and evening hours in patients with elderly metabolic syndrome
 

Background: Metabolic syndrome associated with hypertension, lipid and carbohydrate metabolism disorders in the elderly and senile is common, which indicates the relevance of its study, including the study ...

The prevalence and clinical structure of mental disorders in medical students (problems of primary and secondary psychoprophylaxis)
 

Background: The prevalence of chronic stress among medical students is higher than in the general population due to the high academic load. As a result, anxiety and neurotism ...