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Research Results in Biomedicine

Volume 6, Issue №2, 2020 PDF
Genetics

A novel heterozygous variant in exon 32 of the CHD7 gene (c.6923C>T) in a Syrian family with Kallmann syndrome
 

Background: Kallmann syndrome (KS) and CHARGE syndrome (CS) are rare heritable disorders in which anosmia and hypogonadotropic hypogonadism co-occur. KS is genetically heterogeneous with at least eight genes ...

Study of associations of haplotypes of FLG gene polymorphism with the development of chronic true eczema in men
 

Background: Eczema is a common chronic disease characterized by inflammation of the skin. The aim of the study: To analyze the involvement of haplotypes of polymorphic loci of ...

Association of RS12328675 COBLL1 polymorphism with coronary heart disease and intermediate phenotypes of atherosclerosis: validation study in Central Russia

Background: It is known that the development of coronary heart disease (CHD) as a polygenic multifactorial pathology is determined by a complex interaction between genetic and environmental factors. ...
Pharmacology

A study of neuroprotective properties of the MGLUR4 receptor agonist – ZC64-0001 in comparison with Mexidol
 

Background: One of the most common neurodegenerative diseases is Parkinson's disease, which is based on the degeneration of dopaminergic neurons of the substantia nigra. The modern treatment for ...

Modern possibilities of using the release-active drug Tenoten for Children in the clinical practice of autonomic disorders in children
 

Background: Among the pathological conditions found in children and adolescents, vegetative disorders occupy one of the leading places. The development of autonomic dysfunction is due to an imbalance ...

Exhaled nitric oxide as a predictor of the effectiveness of basic therapy for bronchial asthma in children
 

Background: The article discusses the predictive ability of monitoring nitric oxide in exhaled air relative to the level of control and the likelihood of developing exacerbations of bronchial ...
Medicine (miscellaneous)

Gender features of metabolic disorders in elderly patients with heart failure with mid-range ejection fraction
 

Background: Today, it is important to pay special attention to the increased incidence of heart failure developing with age. Pathogenetic mechanisms detected in metabolic syndrome and atherosclerosis indicate ...

Age aspects of rehabilitation and treatment of osteosarcoarthrosis
 

Background: In older age groups, the problem of osteoporosis is becoming more urgent and acute, as the development of bone fragility leads to numerous fractures and the development ...

Medical Occultism: prevalence and impact on clinical psychiatric practice
 

Background: Occult practices are widespread throughout the world and have a negative effect on adherents among patients. The aim of the study: To analyze the prevalence of medical ...

Features of the course of childbirth in preeclampsia of varying severity at the present stage
 

Background: Identification of complications of childbirth in preeclampsia will enable to improve perinatal outcomes in this group of women, as well as determine the criteria for early and ...