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Research Results in Biomedicine

Volume 6, Issue №3, 2020 PDF
Genetics

2q14 de novo interstitial deletion in a girl with intellectual disabilities and malformations

Background: Neurodevelopmental disorders have a prevalence of approximately 3% in the population, the genetic factor is involved in this condition. Microdeletions that comprise the 2q14.1q14.3 region are rare ...

Association of L432V (rs1056836) polymorphism of the CYP1B1 gene with the increased risk of colorectal cancer in the population of Central Russia

Background: Colon malignancies are one of the most common worldwide. Different pro-carcinogenic agents such as polycyclic aromatic hydrocarbons (PAH) and heterocyclic aromatic amines can potentially play a key ...

Modern genomics in studying the problems of human adaptation to climate in north Siberia

Background: Indigenous people of north Siberia live in some of the harshest natural conditions on Earth, experiencing prolonged exposure to cold, large fluctuations in the length of daylight, ...

Study of associations of candidate genes differentially expressed in the placenta with the development of placental insufficiency with fetal growth restriction

Background: Placental insufficiency (PI) is a key feature of pregnancies with fetal growth restriction (FGR). FGR is defined as pathological inhibition of intrauterine growth of the fetus and ...
Pharmacology

Investigation of cerebroprotective properties of the drug «Mexidol» on the model of pneumococcal bacterial meningitis in experimental conditions

Background: Pneumococcal meningitis is a severe infectious disease, which is characterized by high mortality and frequent development of residual neurological damage. Effective cerebroprotection can improve the outcome of ...
Medicine (miscellaneous)

The proresilients in multimodal programmes for the prevention of premature ageing

Background: Premature ageing is a common process. According to various authors, at least 10-20% of middle-aged people have unfavorable levels of discrepancy between biological and passport age. That ...

Features of myocardial infarction with ST segment elevation in patients of the older age group

Background: Despite the fact that the incidence of myocardial infarction remains extremely high, and the average age of patients (given the increase in average life expectancy) is in ...

Clinical and psychological analysis of emotional and personality disorders in patients with long-term consequences of craniocerebral trauma complicated and uncomplicated by alcoholism

Background: The importance and relevance of studies of neuropsychiatric disorders in the remote period of craniocerebral trauma (CCT) is determined by high incidence of both head injuries (1-4 ...

Premature birth, modern realities

Background: Preterm birth is the main cause of neonatal and infant mortality, child morbidity and disability. The rate of premature birth, despite our knowledge of risk factors, pathogenetic ...