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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2658-6533</journal-id><journal-title-group><journal-title>Research Results in Biomedicine</journal-title></journal-title-group><issn pub-type="epub">2658-6533</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.18413/2313-8955-2017-3-4-11-16</article-id><article-id pub-id-type="publisher-id">1267</article-id><article-categories><subj-group subj-group-type="heading"><subject>Archive categories</subject></subj-group></article-categories><title-group><article-title>CHANGES IN THE LIPID COMPOSITION OF CELL MEMBRANES IN THE CONDITIONS OF PESTICIDES INTOXICATION AND METHODS OF THEIR PREVENTION</article-title><trans-title-group xml:lang="en"><trans-title>CHANGES IN THE LIPID COMPOSITION OF CELL MEMBRANES IN THE CONDITIONS OF PESTICIDES INTOXICATION AND METHODS OF THEIR PREVENTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Korolev</surname><given-names>Vladimir A.</given-names></name><name xml:lang="en"><surname>Korolev</surname><given-names>Vladimir A.</given-names></name></name-alternatives><email>medecol1@yandex.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Korolev</surname><given-names>Ivan V.</given-names></name><name xml:lang="en"><surname>Korolev</surname><given-names>Ivan V.</given-names></name></name-alternatives><email>korolevva@kursksmu.net</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Kharlanov</surname><given-names>Nikita A.</given-names></name><name xml:lang="en"><surname>Kharlanov</surname><given-names>Nikita A.</given-names></name></name-alternatives><email>medecol1@yandex.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Tarasova</surname><given-names>Olga V.</given-names></name><name xml:lang="en"><surname>Tarasova</surname><given-names>Olga V.</given-names></name></name-alternatives><email>medecol1@yandex.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Kononenko</surname><given-names>Nikolay S.</given-names></name><name xml:lang="en"><surname>Kononenko</surname><given-names>Nikolay S.</given-names></name></name-alternatives><email>medecol1@yandex.ru</email></contrib></contrib-group><pub-date pub-type="epub"><year>2017</year></pub-date><volume>3</volume><issue>4</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/medicine/2017/4/Королев_В.А..pdf" /><abstract xml:lang="ru"><p>Today, the problem of high-toxic substances use in the agricultural sphere has a significant character. As a result, the number of intoxication cases has been growing both in warm-blood animals and humans. First of all, the most important toxic effect of pesticides is shown up in the damage of lipid metabolism. To predict the possibility of reducing the harmful pesticide effects, the potential of prophylactic use of Mexidol was studied for normalization of lipid metabolism in rats&amp;rsquo; blood in the background of chronic pesticide intoxication. The study showed that Mexidol has a protective effect for the following lipid fractions: cholesterol and triacylglycerols.</p></abstract><trans-abstract xml:lang="en"><p>Today, the problem of high-toxic substances use in the agricultural sphere has a significant character. As a result, the number of intoxication cases has been growing both in warm-blood animals and humans. First of all, the most important toxic effect of pesticides is shown up in the damage of lipid metabolism. To predict the possibility of reducing the harmful pesticide effects, the potential of prophylactic use of Mexidol was studied for normalization of lipid metabolism in rats&amp;rsquo; blood in the background of chronic pesticide intoxication. The study showed that Mexidol has a protective effect for the following lipid fractions: cholesterol and triacylglycerols.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>chronic pesticide intoxication</kwd><kwd>neutral lipids</kwd><kwd>antioxidants</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic pesticide intoxication</kwd><kwd>neutral lipids</kwd><kwd>antioxidants</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>1. Bryzgunova, S.S. and Eremina, M.V. (2011), &amp;ldquo;Assessment of toxicological effects of pesticides on the human body&amp;rdquo;, Success of Modern Natural Science, 8, 95-96. Russian.</mixed-citation></ref><ref id="B2"><mixed-citation>2. Voronina, T.A. (2009), &amp;ldquo;Mexidol: The main neuropsychotropic effects and the mechanism of action&amp;rdquo;, Pharmateka, 6, 35-38. Russian.</mixed-citation></ref><ref id="B3"><mixed-citation>3. Gerunova, L.K. and Boyko, T.V. (2013), Toxicologiya pesticidov: uchebnoe posobie [Toxicology of pesticides: a textbook], Publishing house &amp;quot;Scientific Library&amp;quot;, Moscow, Russia. Russian.</mixed-citation></ref><ref id="B4"><mixed-citation>4. Gorshinskaya, I.A. (1999), &amp;ldquo;Change in microviscosity of lymphocytes and red blood cells in cancer patients&amp;rdquo;, Issues of med. Chemistry, Vol. 45, 1, 53-57. Russian.</mixed-citation></ref><ref id="B5"><mixed-citation>5. Kozin, G.I., Makarova ,V.A. (1997), Issledovanie sistemy krovi v klinicheskoy praktike [Investigation of the blood system in clinical practice], Mir, Moscow, Russia. Russian.</mixed-citation></ref><ref id="B6"><mixed-citation>6. Krylov, V.I., Vinogradov, A.F., Efremova, S.I. (1984), &amp;ldquo;The method of thin-layer chromatography of lipids of erythrocyte membrane&amp;rdquo;, Lab. Business, 4, 205-206. Russian.</mixed-citation></ref><ref id="B7"><mixed-citation>7. Kuznetsov, V. I, Mironova, N. I. (1996), &amp;ldquo;Some indicatirs of blood plasma lipids and erythrocyte membranes in patients with pharyngeal diphtheria&amp;rdquo;, Kazan. Med. Journal, 4, 266-269. Russian.</mixed-citation></ref><ref id="B8"><mixed-citation>8. Lipovetsky, B.M. (2000), Klinicheskaya lipidologiya [Clinical lipidology], in Lipovetsky, B.M. (ed.), Science, St. Petersburg, Russia. Russian.</mixed-citation></ref><ref id="B9"><mixed-citation>9. Momot, T. V., Kushnerova, N. F., Fomenko, S. E. (2013), &amp;ldquo;Prophylaxis of lipid metabolism of the liver in case of carbon disulfide intoxication&amp;rdquo;, Pacific Journal of Medicine, 2, 57-59. Russian.</mixed-citation></ref><ref id="B10"><mixed-citation>10. Olshanova, K. M. (1970), Praktikum po khromatograficheskomu analizu [Workshop on chromatographic analysis] in Olshanova, K. M. (ed.), Higher education School, Moscow, Russia. Russian.</mixed-citation></ref><ref id="B11"><mixed-citation>11. Serebrov, V.Yu., Balashov, P.P, Sharypova, N.G. (2004), &amp;ldquo;The lipid spectrum of plasma lymphocyte membranes in the withdrawal syndrome in patients with opioid addiction&amp;rdquo;, Wedge. laboratory Diagn., 4, 10-12. Russian.</mixed-citation></ref><ref id="B12"><mixed-citation>12. Storozhok, S.A., (2001), &amp;ldquo;Changes in the Physico-Chemical Properties of Biological Membranes in the Development of Tolerance to Ethanol&amp;rdquo;, Issues of Med. Chemistry, 2, 42-51. Russian.</mixed-citation></ref><ref id="B13"><mixed-citation>13. Khalilov, E.M. (1982), &amp;ldquo;Structural and functional analysis of erythrocyte membranes with different cholesterol content&amp;rdquo;, Issues of med. Chemistry, Vol.27, 1. 81-86. Russian.</mixed-citation></ref><ref id="B14"><mixed-citation>14. Shapovalova, V.P., Ryzhova, Т.V. and Ryzhov, V.M., (2010), &amp;ldquo;The state of lipid metabolism under the influence of noise and aluminum dust&amp;rdquo;, Medicin of Labor and Industrial Ecology, 7, 18-20. Russian.</mixed-citation></ref><ref id="B15"><mixed-citation>15. Shormanov, V.K., Maslov, S.V., Duritsyn, E.P., Baranov, Yu.N., (2010), &amp;ldquo;Forensic chemical definition of bankol&amp;rdquo;, Sud.-med. Expertise, 6, 39-41.&amp;nbsp;Russian.</mixed-citation></ref><ref id="B16"><mixed-citation>16. Rukmini, R. (2001), &amp;ldquo;Cholesterol Organization in Membranes at Low Concentrations: Effects of Curvature Stress and Membrane Thickness&amp;rdquo; Biophys, J, Vol. 81, 2122-2134.</mixed-citation></ref><ref id="B17"><mixed-citation>17. Zhuang, L. (2005), &amp;ldquo;Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts&amp;rdquo;, J. Clin. Invest., Vol. 115, 959-968.</mixed-citation></ref><ref id="B18"><mixed-citation>18. Devaux, P. F., Morris. R. (2004), &amp;ldquo;Transmembrane asymmetry and lateral domains in biological membranes&amp;rdquo;, Traffic, Vol.5, 4, 241-246.</mixed-citation></ref><ref id="B19"><mixed-citation>19. Yao, Q. (2013), &amp;ldquo;Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues&amp;rdquo;, Lipid J. Res, 4, 1058-1065.</mixed-citation></ref><ref id="B20"><mixed-citation>20. Folch, J., Less, M., Sloane, G. (1957), &amp;ldquo;A simple method for the isolation and purification of total lipides from animal tissues&amp;rdquo;, J. Biol. Chem, Vol. 226, 497-509.</mixed-citation></ref><ref id="B21"><mixed-citation>21. Nilous, T. (2002), &amp;ldquo;Molecular basic of membrane disorders&amp;rdquo;, Acta, J. Haematol, Vol. 108, 4, 210-218.</mixed-citation></ref><ref id="B22"><mixed-citation>22. Ohvo-Rekila, H., Ramstedt, B., Leppimaki, P. (2002), &amp;ldquo;Cholesterol interactions with phosphor-lipids in membranes&amp;rdquo;, Prog. Lipid. Res, Vol. 41, 457-468.</mixed-citation></ref><ref id="B23"><mixed-citation>23. Development Department, Plant Protection Research, Agro Division, Takeda Chemical Industries, Ltd. (1989), &amp;ldquo;Summary of Toxity Studies on Bensultap&amp;rdquo;, J. Pesticide Sci, Vol. 14, 4, 523-529.</mixed-citation></ref></ref-list></back></article>