2658-6533Research Results in Biomedicine2658-653310.18413/2313-8955-2018-4-1-77-871377Archive categoriesSTUDIES ON THE DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF TABLETS FOR TREATMENT OF STOMATITISSTUDIES ON THE DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF TABLETS FOR TREATMENT OF STOMATITISPankrushevaTatjana A.PankrushevaTatjana A.MaravinaIrina N.MaravinaIrina N.imaravina@rambler.ruChekmarevaMarina S.ChekmarevaMarina S.20184100

Among various inflammatory diseases of the oral cavity in children, stomatitis occupies a leading position in dentistry. The urgency of this problem is explained not only by the high prevalence of stomatitis in children's practice, but also by the chronicization of the pathological process, contagiousness and disorders of the immune system. According to the frequency of spread, infectious stomatitis of viral, bacterial or fungal etiology is in the first place. Great importance in the treatment of stomatitis in children is given to the local effects of drugs on the oral mucosa. The article substantiates the use of orodispersible tablets containing methylene blue and benzocaine, having a complex antiseptic and analgesic effect in the treatment of stomatitis of different etiologies.  The article presents the results of experimental substantiation of the orodispersible tablets composition, the choice of the optimal technology for their production and quality indicators of tablet granulates and the finished product.

Among various inflammatory diseases of the oral cavity in children, stomatitis occupies a leading position in dentistry. The urgency of this problem is explained not only by the high prevalence of stomatitis in children's practice, but also by the chronicization of the pathological process, contagiousness and disorders of the immune system. According to the frequency of spread, infectious stomatitis of viral, bacterial or fungal etiology is in the first place. Great importance in the treatment of stomatitis in children is given to the local effects of drugs on the oral mucosa. The article substantiates the use of orodispersible tablets containing methylene blue and benzocaine, having a complex antiseptic and analgesic effect in the treatment of stomatitis of different etiologies.  The article presents the results of experimental substantiation of the orodispersible tablets composition, the choice of the optimal technology for their production and quality indicators of tablet granulates and the finished product.

stomatitismethylene bluebenzocaineexcipientsgranulationorodispersible tabletsstomatitismethylene bluebenzocaineexcipientsgranulationorodispersible tabletsСписок литературыAnurova, M.N., Bakhrushina, Ye.O., Demina, N.B. (2015), “Problemy korrektsii organolepticheskikh svoystv lekarstvennykh preparatov” [Problems of correction of organoleptic properties of medicinal preparations], Razrabotka i registratsiya lekarstvennykh sredstv, 4, 64-73. Russian.Gosudarstvennaya Farmakopeya Rossiyskoy Federatsii. XIII izd. [The State Pharmacopoeia of the Russian Federation III ed.] (2015), М. Russian.Gribkovyye, virusnyye i travmaticheskiye stomatity v klinike terapevticheskoy stomatologii [Fungal, viral and traumatic stomatites in the clinic of therapeutic stomatology] (2013): Uchebnoye posobiye / Pod redaktsiyey d.m.n. K.G. Karakova. Stavropol'.: Fabula, 100 p. Russian.Demina, N.B., Anurova, M.N., Asfura, T. (2013), “Razrabotka retseptury i tekhnologii tabletok s ekstraktom bosvellii” [Formulation and technology of tablets with Boswellia extract], Razrabotka i registratsiya lekarstvennykh sredstv, 4, 12-22. Russian.Drobotko, L.N., Strakhova, S.Yu. (2001), “Printsipy terapii ostrykh stomatitov u detey” [Principles of therapy of acute stomatitis in children], Russkiy meditsinskiy zhurnal, 3, 134-135. Russian.Yelizarova, V.M., Drobot'ko, L.N., Strakhova, S.Yu. (2006), “Ostryy gerpeticheskiy stomatit u detey” [Acute herpetic stomatitis in children], Parodontologiya, 4, 102-104. Russian.Isayeva, N.V., Tulaykin, A.I., Sheshegova, Ye.V. (2017), “Tabletki. Normativnyye trebovaniya gosudarstvennoy farmakopei XIII izdaniya” [Pills. Normative requirements of the State Pharmacopoeia III edition], Razrabotka i registratsiya lekarstvennykh sredstva, 3, 178-183. Russian.Pankrusheva, T.A., Maravina, I.N., Medvedeva, O.A., Chekmareva, M.S. (2017), “Issledovaniya po razrabotke tabletok dlya rassasyvaniya s azitromitsinom” [Studies on the development of tablets for resorption with azithromycin], Razrabotka i registratsiya lekarstvennykh sredstva, 2, 84-88. Russian.Korsunskaya, I.M. (2002), “Lecheniye stomatitov i kheylitov u detey” [The treatment of stomatitis and cheilitis in children], Lechashchiy vrach, 9, 64-65. Russian.Kuznetsov, A.V. (2002), “Vybor uvlazhnitelya pri izgotovlenii tabletok s ispol'zovaniyem predvaritel'nogo granulirovaniya” [Selecting a humectant when making tablets using pre-granulation], Farmatsiya, 6, 27-29. Russian.Kuznetsov, A.V., Kuznetsov, A.A. (2011), “Korrigenty vkusa v proizvodstve lekarstvennykh preparatov” [Flavors in the production of pharmaceuticals], Farmatsiya, 2, 53-56. Russian.Mashkovskiy, M.D. (2005), Lekarstvennyye sredstva. 15-oye izd., pererab i dop. [Medicinal products. 15th ed., revised and updated]. M.: Novaya volna, 1200. Russian.Ostafiychuk, M. A. (2015), “Virusnyy etiologicheskiy faktor pri stomatitakh” [Viral etiologic factor in stomatitis], Molodoy uchenyy, 6, 287-290. URL https://moluch.ru/archive/86/16192/ (date of access: January 25б 2018). Russian.Voskoboynikov, I.V., Avakyan, S.B., Sokol'skaya, T.A., Tyulyayev, I.I., Bagirova, V.L., Kolkhir, V.K., Sakovich, G.S. (2005), “Sovremennyye vspomogatel'nyye veshchestva v proizvodstve tabletok. Ispol'zovaniye vysokomolekulyarnykh soyedineniy dlya sovershenstvovaniya lekarstvennykh form i optimizatsii tekhnologicheskogo protsessa” [Modern auxiliary substances in the production of tablets. The use of high-molecular compounds to improve dosage forms and optimize the technological process], Khimiko-farmatsevticheskiy zhurnal, 1, 22-28. Russian.Narkevich, I.A., Nemyatykh, O.D., Basakina, I.I., Siukayeva, D.D. (2016), “Farmatsevticheskaya razrabotka lekarstvennykh preparatov dlya pediatricheskoy praktiki: fundamental'nyye osnovy i spetsificheskiye osobennosti” [Pharmaceutical development of drugs for pediatric practice: fundamentals and specific features], Razrabotka i registratsiya lekarstvennykh sredstva, 3,194-201. Russian.