2658-6533Research Results in Biomedicine2658-653310.18413/2313-8955-2018-4-3-0-31512GeneticsMOLECULAR-GENETIC DETERMINANTS OF INFERTILITY IN GENITAL ENDOMETRYOSISMOLECULAR-GENETIC DETERMINANTS OF INFERTILITY IN GENITAL ENDOMETRYOSISRadzinskyViktor E.RadzinskyViktor E.AltuchovaOksana B.AltuchovaOksana B.kristalinka@yandex.ru20184300

Background: Genital endometriosis is an urgent problem of modern medicine. It is one of the hard-to-explain diseases and is the cause of reproductive health disorders, a decline in the quality of life and social disadaptation of women of any age. The aim of the study: To evaluate the relationship of genetic markers to the development of infertility in genital endometriosis. Materials and methods: The sample for the study included 428 patients with genital endometriosis: 132 patients with genital endometriosis accompanied by infertility (30.84%) and 296 patients with the onset of pregnancy (69.16%). Genotyping of 32 polymorphic loci of genes-candidates of hyperplastic diseases of the uterus was carried out. An analysis of the role of the polymorphic loci and their combinations in the formation of infertility in genital endometriosis was carried out using the APSampler software. Results: It was found that the risk factors for infertility in genital endometriosis are combinations of genetic variants T (rs243865) MMP-2, 6A (rs3025058) MMP-3, T (rs11568819) MMP-7 and G (rs17577) MMP-9 (OR = 2.08, pperm = 0.009), 2G (rs1799750) MMP-1, 6A (rs3025058) MMP-3 and G (rs17577) MMP-9 (OR = 2.03, pperm = 0.013), T rs4073 IL-8, AA (rs2107538) RANTES and A (rs4512021) I-TAC (OR = 2.23, pperm = 0.009), T (rs4073) IL-8, GA (rs1801157) SDF1 and AA (rs2107538) RANTES (OR = 2.80, pperm = 0.007), and the protective factors of risk of infertility in genital endometriosis combination of molecular genetic factors G (rs1042838) PGR, C (rs484389) PGR, T (rs3798577) ESR1 and C (rs2234693) ESR1 (OR = 0.44, pperm = 0.008), T (rs699517) TYMS and AA (rs1801394) MTRR (OR = 0.30, pperm = 0.022), A (rs4073) IL-8 and G( rs2107538) RANTES (OR = 0.33, pperm = 0.008). Conclusion: Polymorphism of candidate genes is associated with the development of infertility in genital endometriosis.

Background: Genital endometriosis is an urgent problem of modern medicine. It is one of the hard-to-explain diseases and is the cause of reproductive health disorders, a decline in the quality of life and social disadaptation of women of any age. The aim of the study: To evaluate the relationship of genetic markers to the development of infertility in genital endometriosis. Materials and methods: The sample for the study included 428 patients with genital endometriosis: 132 patients with genital endometriosis accompanied by infertility (30.84%) and 296 patients with the onset of pregnancy (69.16%). Genotyping of 32 polymorphic loci of genes-candidates of hyperplastic diseases of the uterus was carried out. An analysis of the role of the polymorphic loci and their combinations in the formation of infertility in genital endometriosis was carried out using the APSampler software. Results: It was found that the risk factors for infertility in genital endometriosis are combinations of genetic variants T (rs243865) MMP-2, 6A (rs3025058) MMP-3, T (rs11568819) MMP-7 and G (rs17577) MMP-9 (OR = 2.08, pperm = 0.009), 2G (rs1799750) MMP-1, 6A (rs3025058) MMP-3 and G (rs17577) MMP-9 (OR = 2.03, pperm = 0.013), T rs4073 IL-8, AA (rs2107538) RANTES and A (rs4512021) I-TAC (OR = 2.23, pperm = 0.009), T (rs4073) IL-8, GA (rs1801157) SDF1 and AA (rs2107538) RANTES (OR = 2.80, pperm = 0.007), and the protective factors of risk of infertility in genital endometriosis combination of molecular genetic factors G (rs1042838) PGR, C (rs484389) PGR, T (rs3798577) ESR1 and C (rs2234693) ESR1 (OR = 0.44, pperm = 0.008), T (rs699517) TYMS and AA (rs1801394) MTRR (OR = 0.30, pperm = 0.022), A (rs4073) IL-8 and G( rs2107538) RANTES (OR = 0.33, pperm = 0.008). Conclusion: Polymorphism of candidate genes is associated with the development of infertility in genital endometriosis.

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