2658-6533Research Results in Biomedicine2658-653310.18413/2313-8955-2018-4-3-0-91522Medicine (miscellaneous)PECULIARITIES OF THE OXIDATIVE STATUS IN ELDERLY PATIENTS WITH TYPE 2 DIABETES MELLITUSPECULIARITIES OF THE OXIDATIVE STATUS IN ELDERLY PATIENTS WITH TYPE 2 DIABETES MELLITUSMursalovAkim U.MursalovAkim U.mursalovakim@mail.ru20184300

Background: With age, diabetes mellitus becomes a frequent health problem in many people. However, to date, various clinical and pathophysiological aspects of the development and prevention of hypoglycemic conditions in diabetes mellitus in old age have not been studied in practice. The aim of the study: To study the features of the oxidative status in elderly patients with type 2 diabetes mellitus. Materials and methods: 148 elderly patients were enrolled in the study, of which 2 groups were formed: 1. Control group – 70 patients with type 2 diabetes mellitus who did not have hypoglycemic episodes during the previous year. 2. The main group consisted of 78 patients with type 2 diabetes who had at least six hypoglycemic episodes during one previous year. As a marker of prooxidation processes, an analysis of the content of 8-hydroxy-2-deoxyguanosine (8-OH-DG) in the blood was used. As markers of antioxidant processes, the analysis of superoxide dismutase (SODM) and catalase (CTLS) in the blood was used. Results: In elderly patients with type 2 diabetes mellitus, accompanied by hypoglycemic conditions, there is a significant prevalence of prooxidative processes, which is manifested by a significantly higher level of 8-OH-DG-42.4±1.2 pmol/l and 35.1±0, respectively, 9 pmol/l (p<0.05); the presence of senile asthenia exacerbates prooxidative processes: in the group with hypoglycemia, the index for senile asthenia of 8-OH-DG is 46.1±1.2 pkmol/l versus 38.01.0 without senile asthenia (p<0.05); in the group without hypoglycemia, the index of 8-OH-DG in senile asthenia is 37.0±1.1 pmol/l versus 31.40.9 without senile asthenia (p<0.05). Conclusion: The study of the oxidative status in diabetes mellitus allowed to reveal that in the group of elderly people with hypoglycemic conditions there was a significant prevalence of prooxidative processes in comparison with the patients without hypoglycemic conditions.

Background: With age, diabetes mellitus becomes a frequent health problem in many people. However, to date, various clinical and pathophysiological aspects of the development and prevention of hypoglycemic conditions in diabetes mellitus in old age have not been studied in practice. The aim of the study: To study the features of the oxidative status in elderly patients with type 2 diabetes mellitus. Materials and methods: 148 elderly patients were enrolled in the study, of which 2 groups were formed: 1. Control group – 70 patients with type 2 diabetes mellitus who did not have hypoglycemic episodes during the previous year. 2. The main group consisted of 78 patients with type 2 diabetes who had at least six hypoglycemic episodes during one previous year. As a marker of prooxidation processes, an analysis of the content of 8-hydroxy-2-deoxyguanosine (8-OH-DG) in the blood was used. As markers of antioxidant processes, the analysis of superoxide dismutase (SODM) and catalase (CTLS) in the blood was used. Results: In elderly patients with type 2 diabetes mellitus, accompanied by hypoglycemic conditions, there is a significant prevalence of prooxidative processes, which is manifested by a significantly higher level of 8-OH-DG-42.4±1.2 pmol/l and 35.1±0, respectively, 9 pmol/l (p<0.05); the presence of senile asthenia exacerbates prooxidative processes: in the group with hypoglycemia, the index for senile asthenia of 8-OH-DG is 46.1±1.2 pkmol/l versus 38.01.0 without senile asthenia (p<0.05); in the group without hypoglycemia, the index of 8-OH-DG in senile asthenia is 37.0±1.1 pmol/l versus 31.40.9 without senile asthenia (p<0.05). Conclusion: The study of the oxidative status in diabetes mellitus allowed to reveal that in the group of elderly people with hypoglycemic conditions there was a significant prevalence of prooxidative processes in comparison with the patients without hypoglycemic conditions.

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