2658-6533Research Results in Biomedicine2658-653310.18413/2313-8955-2019-5-1-0-61610PharmacologyResearch on the expansion of the use of extracts of Rhodiola rosea, Linden cordate and Astragalus aspercentage in clinical practiceResearch on the expansion of the use of extracts of Rhodiola rosea, Linden cordate and Astragalus aspercentage in clinical practiceTemirbulatovaAnna M.TemirbulatovaAnna M.StepanovaEleonora F.StepanovaEleonora F.EFStepanova@yandex.ruVeselovaDaria V.VeselovaDaria V.d_veselova@mail.ruLezhnevaLarisa P.LezhnevaLarisa P.20195100

Background: One of the problems of modern medicine is to ensure the prevention of a number of diseases caused by a lack of trace elements in the human body, and are associated with changes in environmental and social factors. However, to obtain the necessary effect for preventive purposes, it is not always advisable to use powerful drugs, on the contrary, it is recommended to use medicines derived from medicinal plants and natural substances. Search and development of highly effective, anti-inflammatory, adaptogenic, choleretic drugs from medicinal plant materials are important in modern medicine. The following medicinal plants are well known and are of great interest for clinical practice: Rhodiola rosea, cordata, Astragalus asaraty. The aim of the study: Improvement of the technology of extracts of rhizomes and roots of rhodiola rosea, flowers of linden heart-shaped and grass of astragalus sainfoin liquid, regarding the relationship of phases, the setting of the extraction process and the number of diffusers. Materials and methods: The conditions of extraction of rhizomes and roots of rhodiola rosea, flowers of lime heart-shaped and grass of astragalus sainfoin were studied.  A resource-saving technology for obtaining rhodiola rosea, linden heart-shaped, astragalus of sainfoin extracts of liquid was developed.  The efficiency of the extraction process was not less than 70%.  The parameters of the quality of liquid extracts were determined: the description, the definition of salidroside in the extract of rhodiola rosea, and polyphenols in extracts of lime heart and astragalus sainfoin.  The quantitative determination of biologically active substances (BAS) in raw materials and extracts was carried out with the spectrophotometric method. Results: Technological characteristics of medicinal plant raw materials were determined on the following samples: roots and rhizomes of rhodiola rosea, flowers of lime heart-shaped, grass of astragalus sainfoin. The expediency of this technology and its advantages were shown, consisting in the greater compactness of the instrumentation scheme, the economy and the reduction of the extraction time. An optimal resource-saving technology for extracting raw materials with ethyl alcohol of different concentrations was proposed, which made it possible to increase the extraction efficiency to 70% of the yield of extractive substances.  An optimal technological scheme for obtaining liquid extracts was developed. Conclusion: A resource-saving technology for obtaining rhodiola rosea, linden heart-shaped, astragalus of sainfoin extracts of liquid was developed.  Liquid extracts of rhodiola rosea, astragalus sainfoin are recommended as an adaptogenic agent, and linden heart-shaped extract is an anti-inflammatory agent.

Background: One of the problems of modern medicine is to ensure the prevention of a number of diseases caused by a lack of trace elements in the human body, and are associated with changes in environmental and social factors. However, to obtain the necessary effect for preventive purposes, it is not always advisable to use powerful drugs, on the contrary, it is recommended to use medicines derived from medicinal plants and natural substances. Search and development of highly effective, anti-inflammatory, adaptogenic, choleretic drugs from medicinal plant materials are important in modern medicine. The following medicinal plants are well known and are of great interest for clinical practice: Rhodiola rosea, cordata, Astragalus asaraty. The aim of the study: Improvement of the technology of extracts of rhizomes and roots of rhodiola rosea, flowers of linden heart-shaped and grass of astragalus sainfoin liquid, regarding the relationship of phases, the setting of the extraction process and the number of diffusers. Materials and methods: The conditions of extraction of rhizomes and roots of rhodiola rosea, flowers of lime heart-shaped and grass of astragalus sainfoin were studied.  A resource-saving technology for obtaining rhodiola rosea, linden heart-shaped, astragalus of sainfoin extracts of liquid was developed.  The efficiency of the extraction process was not less than 70%.  The parameters of the quality of liquid extracts were determined: the description, the definition of salidroside in the extract of rhodiola rosea, and polyphenols in extracts of lime heart and astragalus sainfoin.  The quantitative determination of biologically active substances (BAS) in raw materials and extracts was carried out with the spectrophotometric method. Results: Technological characteristics of medicinal plant raw materials were determined on the following samples: roots and rhizomes of rhodiola rosea, flowers of lime heart-shaped, grass of astragalus sainfoin. The expediency of this technology and its advantages were shown, consisting in the greater compactness of the instrumentation scheme, the economy and the reduction of the extraction time. An optimal resource-saving technology for extracting raw materials with ethyl alcohol of different concentrations was proposed, which made it possible to increase the extraction efficiency to 70% of the yield of extractive substances.  An optimal technological scheme for obtaining liquid extracts was developed. Conclusion: A resource-saving technology for obtaining rhodiola rosea, linden heart-shaped, astragalus of sainfoin extracts of liquid was developed.  Liquid extracts of rhodiola rosea, astragalus sainfoin are recommended as an adaptogenic agent, and linden heart-shaped extract is an anti-inflammatory agent.

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