Background: Today, quite a lot of people suffer from allergic conjunctivitis, despite the sufficient market of monocomponent medicines, there is a shortage of combined medicines based on modern substances on the market. The aim of the study: Theoretical justification of the possibility of using water-soluble B vitamins, ascorbic acid, and rutin as substances in combined ophthalmic solutions for allergic conjunctivitis. Materials and methods: Since the inflammatory reaction of the conjunctiva is at the heart of the allergic conjunctivitis, in order to improve the course of the disease, it is rational to introduce into the composition of a combined medicament for its treatment a component that can affect the development of inflammation by another mechanism of action which is different from the mechanism of action of the main active substance. The authors considered soluble and insoluble vitamins with anti-inflammatory properties – ascorbic acid, rutin, thiamine, riboflavin, nicotinic acid, pyridoxine and cyanocobalamin – as research objects for possible introduction of an additional anti-inflammatory agent in the eye drops for the treatment of allergic conjunctivitis. In the literature review, the authors considered in detail the solubility of these vitamins in water, their stability, and the presence of additional properties that could affect the eye in general. Results: In the end of the study, it was found that the introduction of vitamins B2, B3, B12, P into the eye drops on the water base requires the use of various techniques that increase their solubility, because they have poor solubility in water, and, conversely, the introduction of vitamins C, В1, В6 is possible without the use of any additional technological methods. Conclusion: Riboflavin, nicotinic acid and cyanocobalamin can be used as an additional anti-inflammatory component in the composition of eye drops on a water basis for the treatment of allergic conjunctivitis.