2658-6533Research Results in Biomedicine2658-653310.18413/2658-6533-2020-7-1-0-52282Genetics<strong>Features of gene control of blood pressure in patients with hypertensive disorders during pregnancy</strong><br /> &nbsp;<strong>Features of gene control of blood pressure in patients with hypertensive disorders during pregnancy</strong><br /> &nbsp;FetisovaIrina N.FetisovaIrina N.ivgenlab@gmail.comMalyshkinaAnna I.MalyshkinaAnna I.anna_im@mail.ruPanovaIrina A.PanovaIrina A.ia_panova@mail.ruRokotyanskayaElena A.RokotyanskayaElena A.ivgenlab@gmail.comFetisovNikolay S.FetisovNikolay S.ivgenlab@gmail.comRatnikovaSvetlana Y.RatnikovaSvetlana Y.ivgenlab@gmail.com20217100

Background:&nbsp;Chronic arterial hypertension and preeclampsia are multifactorial pathologies, in the development of which many groups of genes are involved in combination with negative environmental influence. The aim of the study:&nbsp;To study molecular genetic markers of an increased risk of developing hypertensive disorders during pregnancy will make it possible to timely form a risk group for early prevention of possible complications. Materials and methods:&nbsp;A study of the polymorphism of genes controlling vascular wall tone was performed using real-time polymerase chain reaction in 49 patients, who were pregnant against the background of chronic arterial hypertension, and 42 women with chronic arterial hypertension and preeclampsia. Results:&nbsp;AGT 704C, CYP11B2 C(-344)T, GNB3 825T/Т variants were shown in patients with chronic arterial hypertension and joined preeclampsia in the genotype significantly more often than in women with chronic arterial hypertension. Conclusion:&nbsp;The presence of these negative polymorphisms in the genotype of a pregnant woman is combined with resistance to a single-component antihypertensive therapy, which requires the appointment of a combined treatment regimen for this category of patients to achieve the target blood pressure level.

Background:&nbsp;Chronic arterial hypertension and preeclampsia are multifactorial pathologies, in the development of which many groups of genes are involved in combination with negative environmental influence. The aim of the study:&nbsp;To study molecular genetic markers of an increased risk of developing hypertensive disorders during pregnancy will make it possible to timely form a risk group for early prevention of possible complications. Materials and methods:&nbsp;A study of the polymorphism of genes controlling vascular wall tone was performed using real-time polymerase chain reaction in 49 patients, who were pregnant against the background of chronic arterial hypertension, and 42 women with chronic arterial hypertension and preeclampsia. Results:&nbsp;AGT 704C, CYP11B2 C(-344)T, GNB3 825T/Т variants were shown in patients with chronic arterial hypertension and joined preeclampsia in the genotype significantly more often than in women with chronic arterial hypertension. Conclusion:&nbsp;The presence of these negative polymorphisms in the genotype of a pregnant woman is combined with resistance to a single-component antihypertensive therapy, which requires the appointment of a combined treatment regimen for this category of patients to achieve the target blood pressure level.

polymorphismgeneallelepregnancyarterial hypertensivepreeclampsiaantihypertensive therapypolymorphismgeneallelepregnancyarterial hypertensivepreeclampsiaantihypertensive therapyСписок литературыRadkov OV. Molecular and genetic aspects of pathogenesis, clinic, prevention and treatment of arterial hypertension in pregnant women [dissertation]. Moscow: Moscow regional research Institute of obstetrics and gynecology; 2012. Russian.Fetisova IN, Panova IA, Malyshkina AI, et al. Gene polymorphisms of the renin-angiotensin-aldosterone system in women with hypertensive disorders in pregnancy. Tavricheskiy Mediko-Biologicheskiy Vestnik. 2017;20(2):160-165. Russian.Fetisov NS, Panova IA, Zinchenko RA, et al. Hereditary risk factors for hypertension disorders during pregnancy. In: Hemostasis and reproduction. Proceedings of the all-Russian conference with international participation; 2017 March 27-29. Saint Petersburg; 2017:42-43. Russian.Reshetnikov E, Ponomarenko I, Golovchenko O, et al. The VNTR Polymorphism of the Endothelial Nitric Oxide Synthase Gene and Blood Pressure in Women at the End of Pregnancy. Taiwanese Journal of Obstetrics and Gynecology. 2019;58(3):390-395. DOI:&nbsp; https://doi.org/10.1016/j.tjog.2018.11.035Zotova TY, Lapaev NN, Azova MM, Distribution of Polymorphisms of the Renin-Angiotensin System Genes (, , and ), , and in Pregnant Patients with Hypertensive Disorders. 2019;167(1)74-78. DOI: https://doi.org/10.1007/s10517-019-04464-6Li C, Peng W, Zhang H, et al. Association of Angiotensin Receptor 2 Gene Polymorphisms With Pregnancy Induced Hypertension Risk. Hypertension in Pregnancy. 2018;37(2):87-92. DOI: https://doi.org/10.1080/10641955.2018.1460666Xie X, Shi X, Xun X, et al. Endothelial Nitric Oxide Synthase Gene Single Nucleotide Polymorphisms and the Risk of Hypertension: A Meta-Analysis Involving 63,258 Subjects. Clinical and Experimental Hypertension. 2017;39(2):175-182. DOI: https://doi.org/10.1080/10641963.2016.1235177Bochkov NP. Medical genetics. Moscow: GEOTAR-Media; 2014. Russian.Baranov VS. The genetic passport is the basis of individual and predictive medicine. Saint-Petersburg (Russia): Izdatel&#39;stvo N-L; 2009. Russian.Chulkov VS, Vereina NK, Sinitsyn SP, et al. Evaluation of an interrelation of target blood pressure achievement and complications and outcomes of pregnancy in arterial hypertension. Cardiovascular Therapy and Prevention. 2014;13(6):23-27. Russian. DOI: https://doi.org/10.15829/1728-8800-2014-6-23-27Kolesnikova LI, Dolgikh VV, Astakhova TA, et al. Polymorphism of angiotensin II alfa-gene of the 1st type in children with secondary hypertension. Acta Biomedica Scientifica. 2014;(2):32-35. Russian.Reshetnikov EA, Akulova LJ, Batluckaja IV. Molecular genetic mechanisms of the functioning of the cardiovascular system and role of the renin-angiotensin system in providing cardiovascular reactions in the body. Scientific bulletins of Belgorod State University. Series: Medicine. Pharmacia. 2013;22(11):179-184. Russian.Jiang X, Sheng H, Li J, et al. Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study. Journal of Human Hypertension. 2009;23:176-181. DOI: https://doi.org/10.1038/jhh.2008.123Gabriel F, Moreira А, Henriques-Coelho Т. Cardiovascular effects of the angiotensin type 2 receptor. Revista Portuguesa de Cardiologia. 2014;33(7):439-449. DOI: https://doi.org/10.1016/j.repc.2014.02.011LJ, &nbsp;Manatunga AK, Tewksbury DA, et al. The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. Journal of Clinical Investigation. 1995;95:948-953. DOI: https://doi.org/10.1172/JCI117803Loskutova TA, Voronin KV, Turchin VN. Prediction of gestational complications in pregnant women with preeclampsia. Medicinskij zhurnal. 2014;1:81-84. Russian.Pavlova TV. Clinical value of the genetically mediated risk of gestosis in pre-pregnant women [dissertation]. Kazan: Kazan State Medical Academy; 2012. Russian.Lin R, Lei Y, Yuan Z, et al. Angiotensinogen gene M235T and T174M polymorphisms and susceptibility of pre-eclampsia: a meta-analysis. Annals of Human Genetics. 2012;76(5):377-386. DOI: https://doi.org/10.1111/j.1469-1809.2012.00722.xZafarmand MH, Nijdam ME, Franx A, et al. The angiotensinogen gene M235T polymorphism and development of preeclampsia/eclampsia: a meta-analysis and meta-regression of observational studies. Journal of Hypertension. 2008;26(9):1726-1734. DOI: https://doi.org/10.1097/HJH.0b013e3283009ca5Casiglia E, Tikhonoff V, Mazza A, et al. C-344T polymorphism of the aldosterone synthase gene and blood pressure in the elderly: a population-based study. Journal of Hypertension. 2005;23(11):1991-1996. DOI: https://doi.org/10.1097/01.hjh.0000183119.92455.a7Paillard F, Chansel D, Brand E, et al. Genotype-phenotype relationships for the renin-angiotensin-aldosterone system in a normal population. Hypertension. 1999;34(3):423-429. DOI: https://doi.org/10.1161/01.HYP.34.3.423Rad&#39;kov OV, Zavarin VV, Kalinkin MN. Analysis of Association of vasoactive gene polymorphism with preeclampsia. Byulleten VSNC SO RAMN. 2011;81(5):109-112. Russian.Jansen MW, Bertina RM, Vos HL, et al. C825T polymorphism in the human G protein beta 3 subunit gene and preeclampsia: a case control study. Hypertension in Pregnancy. 2004;23(2):211-218. DOI: https://doi.org/10.1081/PRG-120028482Tang X, Guruju M, Rajendran GP, et al. Role of C825T polymorphism of GNbeta3 gene in preeclampsia. Hypertension in Pregnancy. 2006;25(2):93-101. DOI: https://doi.org/10.1080/10641950600745418Zavarin VV, Kalinkin MN, Rad&#39;kov OV. The role of intergenic interactions of vasoactive genes in the formation of predisposition to preeclampsia. Fundamental&#39;nye issledovanija. 2011;11(1):36-38. Russian.