The article provides the analysis of cholesterol spectrum indices, homocysteine levels, and vascular wall rigidity in 120 patients of the cardiology department. The authors have revealed abnormalities of lipid spectrum of blood serum leading to hypertriglyceridemia, the increase in low density lipoprotein (LDLP) cholesterol, and decrease in high density lipoproteins (HDLP). The article demonstrates the clinical and pathogenic relationship of lipid profile with pro-inflammatory factors in patients with metabolic syndrome (MS) and coronary artery disease (CAD), as well as the interrelation of hyperhomocysteinemia (HHC) and LDL cholesterol. Since the progression of MS and CAD is associated with the development of endotheliosis, it is possible that the increase in systemic inflammation factors and development provokes HHC, i.e., effects on the inflammatory process are likely to have a corrective impact on HHC. Therefore, the study once again confirms the fact that MS identifies markers of chronic inflammation compared to the other so-called traditional risk factors of cardiovascular disease. The increased non- HDLP cholesterol level, as well as the activity of nonspecific inflammation in MS, may serve a poor prognostic marker of cardiovascular disorders.