2658-6533Research Results in Biomedicine2658-653310.18413/2658-6533-2020-7-1-0-82327Medicine (miscellaneous)<strong>Mismatch of daily biorhythms of blood pressure and heart rate in elderly patients with myocardial infarction</strong><strong>Mismatch of daily biorhythms of blood pressure and heart rate in elderly patients with myocardial infarction</strong>LutaiYuliya A.LutaiYuliya A.office@ma.sfuv.ru20217100

Background:&nbsp;Myocardial infarction in the elderly population of our country is a leading cause of disability and mortality. In the development of myocardial infarction, an important role is given to desynchronization of circadian hemodynamic rhythms. The aim of the study:&nbsp;To analyze the mismatch of daily biorhythms of blood pressure and heart rate in elderly patients with myocardial infarction. Materials and methods:&nbsp;A survey of 118 patients with myocardial infarction aged 60-74 years. The diagnostics of the disease was carried out on the basis of symptoms of acute myocardial ischemia, ischemic ECG changes, pathological Q wave, loss of myocardial viability, using imaging methods. Daily monitoring of blood pressure was carried out by the &laquo;SpaceLabsMedical&raquo; apparatus for 50-75 hours, according to which chronobiological indicators were calculated: acrophase, orthophase, period and amplitude of biorhythms. Results:&nbsp;Significant differences were found in the duration of the period, the time of onset of acrophase and orthophase in patients with myocardial infarction for circadian rhythms of systolic and diastolic blood pressure, indicating the presence of desynchronosis. Mismatch of biorhythms was also revealed between pulse blood pressure, heart rate with systolic and diastolic blood pressure. Mismatch is more characteristic of acrophase and the period of the hemodynamic components under consideration. Conclusion:&nbsp;The revealed patterns of mismatch of the chronobiological hemodynamic parameters in elderly patients with myocardial infarction should be considered when prescribing drugs.

Background:&nbsp;Myocardial infarction in the elderly population of our country is a leading cause of disability and mortality. In the development of myocardial infarction, an important role is given to desynchronization of circadian hemodynamic rhythms. The aim of the study:&nbsp;To analyze the mismatch of daily biorhythms of blood pressure and heart rate in elderly patients with myocardial infarction. Materials and methods:&nbsp;A survey of 118 patients with myocardial infarction aged 60-74 years. The diagnostics of the disease was carried out on the basis of symptoms of acute myocardial ischemia, ischemic ECG changes, pathological Q wave, loss of myocardial viability, using imaging methods. Daily monitoring of blood pressure was carried out by the &laquo;SpaceLabsMedical&raquo; apparatus for 50-75 hours, according to which chronobiological indicators were calculated: acrophase, orthophase, period and amplitude of biorhythms. Results:&nbsp;Significant differences were found in the duration of the period, the time of onset of acrophase and orthophase in patients with myocardial infarction for circadian rhythms of systolic and diastolic blood pressure, indicating the presence of desynchronosis. Mismatch of biorhythms was also revealed between pulse blood pressure, heart rate with systolic and diastolic blood pressure. Mismatch is more characteristic of acrophase and the period of the hemodynamic components under consideration. Conclusion:&nbsp;The revealed patterns of mismatch of the chronobiological hemodynamic parameters in elderly patients with myocardial infarction should be considered when prescribing drugs.

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