2658-6533Research Results in Biomedicine2658-653310.18413/2658-6533-2021-7-2-0-42387Genetics<strong>Influence of some risk factors and rs1799930 polymorphism of the <em>NAT2-590</em> G&gt;A gene on the development of chronic pancreatitis</strong><br /> &nbsp;<strong>Influence of some risk factors and rs1799930 polymorphism of the <em>NAT2-590</em> G&gt;A gene on the development of chronic pancreatitis</strong><br /> &nbsp;SamginaTatyana A.SamginaTatyana A.tass@list.ru20217200

Background:&nbsp;Genetic and environmental factors are involved in the development of chronic pancreatitis. The aim of the study:&nbsp;To determine the influence of some risk factors and polymorphism rs1799930 NAT2-590 G&gt;A on the development of chronic pancreatitis. Materials and methods:&nbsp;302 unrelated patients with chronic pancreatitis and 465 healthy individuals. When questioning the study participants, the impact of smoking and alcohol consumption on the risk of developing the disease was assessed depending on the volume, frequency and duration. Genotyping of the polymorphism rs1799930 NAT2-590 G&gt;A was carried out by PCR. Statistical data processing was carried out using Statistica 10.0 (StatSoft), SNPstats. Results:&nbsp;It was found that smoking, frequency and duration of alcohol abuse affect the likelihood of developing the disease. Patients with genotype G/G NAT2 -590 G&gt;A were less likely to suffer from chronic pancreatitis with moderate alcohol consumption (frequency of alcohol consumption less than 2 times a week &ndash; OR=0.55, 95% CI 0.36-0.85; P=0.006; duration of alcohol consumption less than 10 years &ndash; OR=0.57, 95% CI 0.36-0.90) P=0.015) and non-smokers (OR=0.67, 95% CI 0.47-0.96); P =0.03). Conclusion:&nbsp;When predicting the likelihood of CP in carriers of the polymorphic variant rs1799930 NAT2 -590 G&gt;A, it is necessary to take into account the effect of smoking and alcohol abuse. Genotype G/G rs1799930 of the NAT2 -590 G&gt;A gene has a protective effect in moderate alcohol consumption and in non-smoking respondents.

Background:&nbsp;Genetic and environmental factors are involved in the development of chronic pancreatitis. The aim of the study:&nbsp;To determine the influence of some risk factors and polymorphism rs1799930 NAT2-590 G&gt;A on the development of chronic pancreatitis. Materials and methods:&nbsp;302 unrelated patients with chronic pancreatitis and 465 healthy individuals. When questioning the study participants, the impact of smoking and alcohol consumption on the risk of developing the disease was assessed depending on the volume, frequency and duration. Genotyping of the polymorphism rs1799930 NAT2-590 G&gt;A was carried out by PCR. Statistical data processing was carried out using Statistica 10.0 (StatSoft), SNPstats. Results:&nbsp;It was found that smoking, frequency and duration of alcohol abuse affect the likelihood of developing the disease. Patients with genotype G/G NAT2 -590 G&gt;A were less likely to suffer from chronic pancreatitis with moderate alcohol consumption (frequency of alcohol consumption less than 2 times a week &ndash; OR=0.55, 95% CI 0.36-0.85; P=0.006; duration of alcohol consumption less than 10 years &ndash; OR=0.57, 95% CI 0.36-0.90) P=0.015) and non-smokers (OR=0.67, 95% CI 0.47-0.96); P =0.03). Conclusion:&nbsp;When predicting the likelihood of CP in carriers of the polymorphic variant rs1799930 NAT2 -590 G&gt;A, it is necessary to take into account the effect of smoking and alcohol abuse. Genotype G/G rs1799930 of the NAT2 -590 G&gt;A gene has a protective effect in moderate alcohol consumption and in non-smoking respondents.

chronic pancreatitisrisk factorsrs1799930NAT2chronic pancreatitisrisk factorsrs1799930NAT2Список литературыKhatkov IE, Maev IV, Abdulkhakov SR, et al. The Russian consensus on the diagnosis and treatment of chronic pancreatitis. Therapeutic archive. 2017;89(2):105-113. Russian. DOI: https://doi.org/10.17116/terarkh2017892105-113Conwell DL, Lee LS, Yadav D, American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines. Pancreas. 2014;43(8):1143-62. DOI: https://doi.org/10.1097/MPA.0000000000000237Conwell DL, Banks PA, Sandhu BS, Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group. Digestive Diseases and Sciences. 2017;62(8):2133-2140. DOI: https://doi.org/10.1007/s10620-017-4621-zKleeff J, Whitcomb DC, Shimosegawa T, et al. Chronic pancreatitis. Nature Reviews Disease Primers. 2017;3:17060. DOI: https://doi.org/10.1038/nrdp.2017.60Sankaran SJ, Xiao AY, Wu LM, et al. Frequency of progression from acute to chronic pancreatitis and risk factors: a meta-analysis. . 2015;(6):1490-1500.e1. DOI: https://doi.org/10.1053/j.gastro.2015.07.066Muniraj T, Yadav D, Abberbock JN, et al. Increased awareness enhances physician recognition of the role of smoking in chronic pancreatitis. . 2020;(3):23-31. DOI: https://doi.org/10.33149/vkp.2020.03.04Huang BZ, Wang S, Bogumil D, et al. Red meat consumption, cooking mutagens, NAT1/2 genotypes, and pancreatic cancer risk in two racially diverse prospective cohorts. . 2021:33844845. DOI: https://doi.org/10.1002/ijc.33598Geller F, Soborg B, Koch A, et al. Determination of NAT2 acetylation status in the Greenlandic population. Archives of Toxicology. 2016;90:883-889. DOI: https://doi.org/10.1007/s00204-015-1501-1Kasajova P, Holubekova V, Mendelova A, et al. Active cigarette smoking and the risk of breast cancer at the level of N-acetyltransferase 2 (NAT2) gene polymorphisms. . 2016;6):7929-7937. DOI: https://doi.org/10.1007/s13277-015-4685-3Tian F, Zhang Y, Ren Y, Shen L. N-Acetyltransferase 2 (NAT2) gene polymorphism and exposure to smoking in lung cancer of Chinese males. . 2014;8):90. DOI: https://doi.org/10.1007/s12032-014-0090-9Zou Y, Dong S, Xu S, et al. Genetic polymorphisms of NAT2 and risk of acute myeloid leukemia: A case-control study. . 2017;96(42):e7499. DOI: https://doi.org/10.1097/MD.0000000000007499