Background: Diabetic retinopathy remains one of the leading causes of visual impairment, however, the deficit profile of these patients, with the exception of cognitive and anxiety-depressive disorders, remains virtually unexplored. The geriatric tactics of managing patients with diabetic retinopathy also needs justification. The aim of the study: Substantiation and evaluation of the effectiveness of geriatric management tactics for patients with diabetic retinopathy. Materials and methods: In clinical conditions, 244 patients suffering from diabetic retinopathy were examined. In these patients a comprehensive ophthalmological and geriatric assessment was performed in accordance with the recommendations of the Russian Association of Gerontologists and Geriatricians. The leading clinical geriatric syndromes were studied in 244 patients with diabetic retinopathy and 200 patients without this disease. Taking into account the performed comprehensive geriatric assessment, the geriatric tactics of managing patients with diabetic retinopathy (main group, n=127) was scientifically substantiated and implemented. The control consisted of 117 patients with diabetic retinopathy who underwent standard therapeutic measures. Evaluation of the effectiveness of the treatment was carried out after 1 year. Results: In patients with diabetic retinopathy, the risk syndrome of falls was significantly more often diagnosed – 64.2±3.1 versus 12.5±2.3 cases in patients without diabetic retinopathy per 100 examined, the syndrome of falls – 45.0±3.2 cases versus 19.5±2.87 cases per 100 examined, anxiety-depressive syndrome 65.8±3.2 cases versus 41.5±3.5 cases per 100 examined, violations of general motor activity – 47.9±3.2 versus 18.5±2.7 cases per 100 examined. The use of geriatric management tactics in the main group, including correction of visual deficit, fall syndrome and risk of falls, normalization of sleep, conducting courses of psychotherapy, the use of "Tykveol" to improve geriatric and oxidative status, the use of "Sulodexide" to correct hemocirculatory disorders, significantly reduced the frequency of deficiency syndromes and, above all, the syndrome of risk of falls to 34.4±4.2 vs. 60.0±4.6 cases per 100 treated in the control group, falls syndrome up to 23.2±3.8 cases vs. 36.5±4.5 cases, anxiety-depressive syndrome up to 32.8±4.2 cases versus 57.4±4.6 cases, respectively. Conclusion: Geriatric tactics of managing patients with diabetic retinopathy is more effective