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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2658-6533</journal-id><journal-title-group><journal-title>Research Results in Biomedicine</journal-title></journal-title-group><issn pub-type="epub">2658-6533</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.18413/2658-6533-2023-9-3-0-10</article-id><article-id pub-id-type="publisher-id">3170</article-id><article-categories><subj-group subj-group-type="heading"><subject>Medicine (miscellaneous)</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;Dynamics of detection of narcotic compounds for 2013-2021: a case study of the Republic of Bashkortostan&lt;/strong&gt;&lt;br /&gt;
&amp;nbsp;</article-title><trans-title-group xml:lang="en"><trans-title>&lt;strong&gt;Dynamics of detection of narcotic compounds for 2013-2021: a case study of the Republic of Bashkortostan&lt;/strong&gt;&lt;br /&gt;
&amp;nbsp;</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Efremov</surname><given-names>Ilia S.</given-names></name><name xml:lang="en"><surname>Efremov</surname><given-names>Ilia S.</given-names></name></name-alternatives><email>efremovilya102@gmail.com</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Galeeva</surname><given-names>Elena H.</given-names></name><name xml:lang="en"><surname>Galeeva</surname><given-names>Elena H.</given-names></name></name-alternatives><email>xtl.ufa@yandex.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Nikolaev</surname><given-names>Ivan V.</given-names></name><name xml:lang="en"><surname>Nikolaev</surname><given-names>Ivan V.</given-names></name></name-alternatives><email>nikolaev.i.86@gmail.com</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Akhmetgareeva</surname><given-names>Galiya R.</given-names></name><name xml:lang="en"><surname>Akhmetgareeva</surname><given-names>Galiya R.</given-names></name></name-alternatives><email>galiya_rad@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Abdrakhmanova</surname><given-names>Anastasia E.</given-names></name><name xml:lang="en"><surname>Abdrakhmanova</surname><given-names>Anastasia E.</given-names></name></name-alternatives><email>anastasiamosyakova@yandex.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Ashurov</surname><given-names>Zarifzhon Sh.</given-names></name><name xml:lang="en"><surname>Ashurov</surname><given-names>Zarifzhon Sh.</given-names></name></name-alternatives><email>zarif.ashurov@tma.uz</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Nasyrova</surname><given-names>Regina F.</given-names></name><name xml:lang="en"><surname>Nasyrova</surname><given-names>Regina F.</given-names></name></name-alternatives><email>nreginaf77@gmail.com</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Asadullin</surname><given-names>Azat R.</given-names></name><name xml:lang="en"><surname>Asadullin</surname><given-names>Azat R.</given-names></name></name-alternatives><email>droar@yandex.ru</email></contrib></contrib-group><pub-date pub-type="epub"><year>2023</year></pub-date><volume>9</volume><issue>3</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/medicine/2023/3/НРБИ_2023_3-115-130.pdf" /><abstract xml:lang="ru"><p>Background: The consumption of psychoactive substances remains an urgent problem for modern society. The convenient geographical location on the way from China to central Russia and Europe makes Bashkiria an interesting region for studying the epidemiology of drug use detection. Despite the availability of various research methods, at the moment there are not so many works on the study of drug addiction of the population based on direct signs &amp;ndash; the number of substances detected in samples taken from persons undergoing narcological examination. The aim of the study: To evaluate the dynamics of detected groups of psychoactive substances among the population of the Republic of Bashkortostan for 2013-2021 according to laboratory studies. Materials and methods: Biological samples of 27 022 people aged 18 to 65 years were studied by the immunochromatographic method. The study sample included 2 971 females and 24 051 males. The study was conducted on the territory of the Republic of Bashkortostan in 2013-2021. Confirmatory chemical and toxicological studies to determine the presence of narcotic drugs and psychotropic substances in the biomaterial were conducted on the basis of the clinical diagnostic laboratory of the Republican Clinical Narcological Dispensary of the Ministry of Health of the Republic of Bashkortostan. Data processing was carried out by methods of parametric statistics. Results: The paper shows the dynamics, quantitative and qualitative trends in the detection of substances. The distribution of identified drug users by year was as follows: 2013 &amp;ndash; 3 003; 2014 &amp;ndash; 3 849; 2015 &amp;ndash; 2 721; 2016 &amp;ndash; 3 580; 2017 &amp;ndash; 3 806; 2018 &amp;ndash; 3 104; 2019 &amp;ndash; 2 375; 2020 &amp;ndash; 1 943; 2021 &amp;ndash; 2 641. There are more men than women among the identified drug users. Age-related consumption patterns were found: younger drug users prefer cannabinoids, older users prefer opiates and sedatives. The most common psychoactive substances are psychostimulants (synthetic cathinones) and cannabinoids. The consumption of one narcotic substance is more common than polyconsumption. Conclusion: It can be concluded that the level of consumption of narcotic substances on the territory of the Republic of Bashkortostan is not decreasing, only its structure is changing. The presented data are of an overview nature and require further in-depth study.</p></abstract><trans-abstract xml:lang="en"><p>Background: The consumption of psychoactive substances remains an urgent problem for modern society. The convenient geographical location on the way from China to central Russia and Europe makes Bashkiria an interesting region for studying the epidemiology of drug use detection. Despite the availability of various research methods, at the moment there are not so many works on the study of drug addiction of the population based on direct signs &amp;ndash; the number of substances detected in samples taken from persons undergoing narcological examination. The aim of the study: To evaluate the dynamics of detected groups of psychoactive substances among the population of the Republic of Bashkortostan for 2013-2021 according to laboratory studies. Materials and methods: Biological samples of 27 022 people aged 18 to 65 years were studied by the immunochromatographic method. The study sample included 2 971 females and 24 051 males. The study was conducted on the territory of the Republic of Bashkortostan in 2013-2021. Confirmatory chemical and toxicological studies to determine the presence of narcotic drugs and psychotropic substances in the biomaterial were conducted on the basis of the clinical diagnostic laboratory of the Republican Clinical Narcological Dispensary of the Ministry of Health of the Republic of Bashkortostan. Data processing was carried out by methods of parametric statistics. Results: The paper shows the dynamics, quantitative and qualitative trends in the detection of substances. The distribution of identified drug users by year was as follows: 2013 &amp;ndash; 3 003; 2014 &amp;ndash; 3 849; 2015 &amp;ndash; 2 721; 2016 &amp;ndash; 3 580; 2017 &amp;ndash; 3 806; 2018 &amp;ndash; 3 104; 2019 &amp;ndash; 2 375; 2020 &amp;ndash; 1 943; 2021 &amp;ndash; 2 641. There are more men than women among the identified drug users. Age-related consumption patterns were found: younger drug users prefer cannabinoids, older users prefer opiates and sedatives. The most common psychoactive substances are psychostimulants (synthetic cathinones) and cannabinoids. The consumption of one narcotic substance is more common than polyconsumption. Conclusion: It can be concluded that the level of consumption of narcotic substances on the territory of the Republic of Bashkortostan is not decreasing, only its structure is changing. The presented data are of an overview nature and require further in-depth study.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>drugs</kwd><kwd>drug use</kwd><kwd>opiates</kwd><kwd>cannabinoids</kwd><kwd>cathinones</kwd><kwd>immunochromatographic method</kwd></kwd-group><kwd-group xml:lang="en"><kwd>drugs</kwd><kwd>drug use</kwd><kwd>opiates</kwd><kwd>cannabinoids</kwd><kwd>cathinones</kwd><kwd>immunochromatographic method</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>Brun EA, Letnikova LI, Evdokimov AYu, et al. On monitoring of population mortality related to the use of psychoactive substances. Public Health. 2021;1(1):44-55. Russian. DOI: https://doi.org/10.21045/2782-1676-2021-1-1-44-55</mixed-citation></ref><ref id="B2"><mixed-citation>Koshkina EA, Bryun EA, Kirzhanova VV, et al. Monitoring of mental and behavioral disorders associated with the use of psychoactive substances in Moscow in 2017-2018. Narcology. 2020;19(4):22-34. Russian. DOI: https://doi.org/10.25557/1682-8313.2020.04.22-34</mixed-citation></ref><ref id="B3"><mixed-citation>Extract from the report on the drug situation in the Russian Federation in 2020 [Internet] [cited 2022 June 19]. Russian. Available from: https://www.gov.spb.ru/static/writable/ckeditor/uploads/2021/11/24/24/%D0%92%D1%8B%D0%BF%D0%B8%D1%81%D0%BA%D0%B0_%D0%94%D0%BE%D0%BA%D0%BB%D0%B0%D0%B4_%D0%9D%D0%A1_%D0%A0%D0%A4_2020__07_2021.doc</mixed-citation></ref><ref id="B4"><mixed-citation>Indicators of crime in Russia. Map. [Internet] [cited 2022 June 25]. Russian. Available from: http://crimestat.ru/offenses_map</mixed-citation></ref><ref id="B5"><mixed-citation>Asadullin AR. The overview of the prevalence of synthetic cannabinoids in the Republic of Bashkortostan. Bashkortostan Medical Journal. 2016;11(6(66)):61-64. Russian.</mixed-citation></ref><ref id="B6"><mixed-citation>Asadullin AR, Asadullina GM, Timerbulatova MF, et al. Analysis of suicidal behavior among consumers of &amp;quot;designer&amp;quot; drugs. Pedagogical Journal of Bashkortostan. 2017;1(68):112-118. Russian. DOI: https://doi.org/ 10.21510/1817-3292-2017-1-112-118</mixed-citation></ref><ref id="B7"><mixed-citation>Asadullin AR. Dynamics of psychoactive substance consumption in the Republic of Bashkortostan with in-depth clinical and genetic study of the formation of dependence on substances of the group of synthetic cathinones [dissertation]. Saint-Petersburg: Bekhterev Psychoneurological Research Institute; 2018. Russian.</mixed-citation></ref><ref id="B8"><mixed-citation>Savchishkina OG. Determinants influencing anesthesia of the population in the Republic of Bashkortostan. Gaps in Russian Legislation. 2015;1:176-178. Russian.</mixed-citation></ref><ref id="B9"><mixed-citation>Teplyashin PV, Mamay EA. Criminological and sociological characteristics of illicit drug trafficking of the opium group in the Volga Federal District. Journal of the Perm Institute of the FPS of Russia. 2020;3:53-61. Russian.</mixed-citation></ref><ref id="B10"><mixed-citation>Var&amp;igrave; MR, Mannocchi G, Tittarelli R, et al. New psychoactive substances: evolution in the exchange of information and innovative legal responses in the European Union. International Journal of Environmental Research and Public Health. 2020;17(22):8704. DOI: https://doi.org/10.3390/ijerph17228704</mixed-citation></ref><ref id="B11"><mixed-citation>Peacock A, Bruno R, Gisev N, et al. New psychoactive substances: challenges for drug surveillance, control, and public health responses. The Lancet. 2019;394(10209):1668-1684. DOI: https://doi.org/10.1016/S0140-6736(19)32231-7</mixed-citation></ref><ref id="B12"><mixed-citation>Zanfrognini B, Pigani L, Zanardi C. Recent advances in the direct electrochemical detection of drugs of abuse. Journal of Solid State Electrochemistry. 2020;24:2603-2616. DOI: https://doi.org/10.1007/s10008-020-04686-z</mixed-citation></ref><ref id="B13"><mixed-citation>Rahimi A, Nojavan S, Tabani H, et al. Inside gel electromembrane extraction: A novel green methodology for the extraction of morphine and codeine from human biological fluids. Journal of Pharmaceutical and Biomedical Analysis. 2020;184:113175. DOI: https://doi.org/10.1016/j.jpba.2020.113175</mixed-citation></ref><ref id="B14"><mixed-citation>Huestis MA, Smith ML. Cannabinoid markers in biological fluids and tissues: revealing intake. Trends in Molecular Medicine. 2018;24(2):156-172. DOI: https://doi.org/10.1016/j.molmed.2017.12.006</mixed-citation></ref><ref id="B15"><mixed-citation>Mao K, Zhang H, Pan Y. Biosensors for wastewater-based epidemiology for monitoring public health. Water Research. 2021;191:116787. DOI: https://doi.org/10.1016/j.watres.2020.116787</mixed-citation></ref><ref id="B16"><mixed-citation>Foppe KS, Hammond-Weinberger DR, Subedi B. Estimation of the consumption of illicit drugs during special events in two communities in Western Kentucky, USA using sewage epidemiology. Science of the Total Environment. 2018;633:249-256. DOI: https://doi.org/10.1016/j.scitotenv.2018.03.175</mixed-citation></ref><ref id="B17"><mixed-citation>Daglioglu N, Guzel EY, Kilercioglu S. Assessment of illicit drugs in wastewater and estimation of drugs of abuse in Adana Province, Turkey. Forensic Science International. 2019;294:132-139. DOI: https://doi.org/10.1016/j.forsciint.2018.11.012</mixed-citation></ref><ref id="B18"><mixed-citation>Woźniak MK, Wiergowski M, Aszyk J, et al. Application of gas chromatography&amp;ndash;tandem mass spectrometry for the determination of amphetamine-type stimulants in blood and urine. Journal of Pharmaceutical and Biomedical Analysis. 2018;148:58-64. DOI: https://doi.org/10.1016/j.jpba.2017.09.020</mixed-citation></ref><ref id="B19"><mixed-citation>Gerace E, Caneparo D, Borio F, et al. Determination of several synthetic cathinones and an amphetamine-like compound in urine by gas chromatography with mass spectrometry. Method validation and application to real cases. Journal of Separation Science. 2019;42(8):1577-1584. DOI: https://doi.org/10.1002/jssc.201801249</mixed-citation></ref><ref id="B20"><mixed-citation>Tang SH, Chuang CH, Chen SF, et al. Optimized procedures for simultaneous quantitation of low concentration levels of morphine and codeine in urine using gas chromatography&amp;ndash;mass spectrometry. Journal of Medical Science. 2020;40(2):68-75. DOI: https://doi.org/ 10.4103/jmedsci.jmedsci_124_19</mixed-citation></ref><ref id="B21"><mixed-citation>World Drug Report 2020 (United Nations publication, Sales No. E.20.XI.6). [Internet] [cited 2022 September 10]. Available from: https://wdr.unodc.org/wdr2020/field/WDR20_Booklet_5.pdf</mixed-citation></ref><ref id="B22"><mixed-citation>Been F, Emke E, Matias J, et al. Changes in drug use in European cities during early COVID-19 lockdowns &amp;ndash; A snapshot from wastewater analysis. Environment International. 2021;153:106540. DOI; https://doi.org/10.1016/j.envint.2021.106540</mixed-citation></ref><ref id="B23"><mixed-citation>Chiappini S, Guirguis A, John A, et al. COVID-19: The hidden impact on mental health and drug addiction. Frontiers in Psychiatry. 2020;11:767. DOI: https://doi.org/10.3389/fpsyt.2020.00767</mixed-citation></ref><ref id="B24"><mixed-citation>Scherbaum N, Bonnet U, Hafermann H, et al. Availability of illegal drugs during the COVID-19 pandemic in Western Germany. Frontiers in Psychiatry. 2021;12:648273. DOI: https://doi.org/10.3389/fpsyt.2021.648273</mixed-citation></ref><ref id="B25"><mixed-citation>Gonis GI. Illicit drugs use among youth: a hindrance to socio-economic development in Rwanda. Social Research Reports. 2018;10(2):74-84.</mixed-citation></ref><ref id="B26"><mixed-citation>Pozdniakova ME, Bryuno VV. Comparative analysis of changes in drug situation in Russia for 30 years: 1990-2020. Journal of Addiction Problems. 2021;5(200):15-51. Russian. DOI: https://doi.org/ 10.47877/0234-0623_2021_05_15</mixed-citation></ref><ref id="B27"><mixed-citation>Pleshakov AA, Cherkudinov DA. Desomorphine fever. Drug control. 2010;3:35-36. Russian.</mixed-citation></ref><ref id="B28"><mixed-citation>Winstock AR, Davies EL, Gilchrist G, et al. Global Drug Survey special edition on COVID-19 global interim report [Internet] [cited 2022 Nov 1]. Available from: https://www.globaldrugsurvey.com/wp-content/themes/globaldrugsurvey/assets/GDS_COVID-19-GLOBAL_Interim_Report-2020.pdf</mixed-citation></ref></ref-list></back></article>