2658-6533Research Results in Biomedicine2658-653310.18413 / 2313-8955-2015-1-1-4-9341Archive categoriesAPELIN-ADDITIONAL MARKER OF INSULIN RESISTANCEAPELIN-ADDITIONAL MARKER OF INSULIN RESISTANCEShekhovtsovaYulia A.ShekhovtsovaYulia A.vnmed3@gmail.comZhuravlyovaLarysa V.ZhuravlyovaLarysa V.prof.zhuravlyova@gmail.com20151100

The purpose of the present study was to determine the correlations between the state of carbohydrate metabolism and concentrations of apelin in blood of patients with type 2 diabetes mellitus with different phenotypes. Materials and methods: a total of 32 patients with type 2 diabetes mellitus with different phenotypes (13 men, mean age 56,77 ± 1,79 years) were examined. The control group included 20 healthy individuals. Results: the significant elevation of adipocytokine apelin level was found. The significant correlations between body mass index, apelin and the parameters of carbohydrate metabolism were defined. Conclusions: the increased levels of apelin and connection between this adipocytokine and anthropometric parameters, as well as the indices of carbohydrate metabolism suggest that the elevated body weight contributes to activation and strengthening of impact mechanisms of adipose tissue hormones on metabolic status.

The purpose of the present study was to determine the correlations between the state of carbohydrate metabolism and concentrations of apelin in blood of patients with type 2 diabetes mellitus with different phenotypes. Materials and methods: a total of 32 patients with type 2 diabetes mellitus with different phenotypes (13 men, mean age 56,77 ± 1,79 years) were examined. The control group included 20 healthy individuals. Results: the significant elevation of adipocytokine apelin level was found. The significant correlations between body mass index, apelin and the parameters of carbohydrate metabolism were defined. Conclusions: the increased levels of apelin and connection between this adipocytokine and anthropometric parameters, as well as the indices of carbohydrate metabolism suggest that the elevated body weight contributes to activation and strengthening of impact mechanisms of adipose tissue hormones on metabolic status.

type 2 diabetes mellitusapelinbody mass indexincreased body weighttype 2 diabetes mellitusapelinbody mass indexincreased body weightСписок литературыIvashkin V.T. Clinical Variants of Metabolic Syndrome // Izd-vo «Med. inform. Agenstvo»". 2011. 220 p.Fadeenko G.D. Pancreatic Steatosis within the Metabolic Syndrome: an equation with many unknown // Vestnik kluba Pankreatologov.2010.№1.Pp. 21-25.Cantley J. The Control of Insulin Secretion by Adipokines: Current Evidence for Adipocyte-beta Cell Endocrine Signalling in Metabolic Homeostasis / J. Cantley //  Mamm Genome. 2014. Vol. 25(9-10). Pp. 442-45.Habchi M. Circulating Apelin is Increased in Patients with Type 1 or Type 2 Diabetes and is Associated with Better Glycaemic Control / M. Habchi, L. Duvillard, V. Cottet [et all] // Clin. Endocrinol. (Oxf). 2014. Vol. 81(5). Pp. 696-701.Xu Shiming Apelin and Insulin Resistance: Another Arrow for the Quiver? / Shiming Xu, Philip S. Tsao, Patrick Yue // J. Diabetes.2011. Vol.3 (3). Pp. 225-231.Yue P. Apelin is Necessary for the Maintenance of Insulin Sensitivity / P. Yue, H. Jin, M. Aillaud-Manzanera et al. // Amer. J. Physiol. Endocrinol. Metab. 2009. 298. Pp. 59-67Zhou W. Transmembrane Tumor Necrosis Factor-alpha Sensitizes Adipocytes to Insulin / Zhou W., Yang P., Liu L. [et all] // Mol. Cell Endocrinol. 2015. Vol. 406. Pp. 78-86. Zhu S. Apelin Stimulates Glucose Uptake through the PI3K/Akt Pathway and Improves Insulin Resistance in 3T3-L1 Adipocytes / S. Zhu, F. Sun, W. Li et al. // Mol. Cell Biochem. 2011. 353(1–2). Pp. 305-313.