2658-6533Research Results in Biomedicine2658-653310.18413/2658-6533-2025-11-4-0-83943Medicine (miscellaneous)<strong>The role of mental disorders in the pathogenesis of atopic dermatitis (review)</strong><strong>The role of mental disorders in the pathogenesis of atopic dermatitis (review)</strong>LevintovaNatalya L.LevintovaNatalya L.Levnataleo@mail.ruKeniksfestYulia V.KeniksfestYulia V.keniksfest@mail.ruRetyunskiyKonstantin Yu.RetyunskiyKonstantin Yu.retiunsk@mail.ruStarusevaAlexandra V.StarusevaAlexandra V.starusevaav@mail.ruRuzhenkovaVictoria V.RuzhenkovaVictoria V.ruzhenkova@bsuedu.ruKhamskayaInna S.KhamskayaInna S.lukyantseva@bsuedu.ru202511400

Background: The problem of atopic dermatitis has received significant attention from researchers across different fields over the years. Despite its high prevalence, there remains an incomplete understanding of the underlying pathogenetic mechanisms, leading to ineffective therapeutic strategies. This lack of consensus regarding a unified model of dermatitis development creates challenges in selecting appropriate treatment options. The aim of the study: To analyze the current scientific literature data describing the relationship between central nervous system damage, psychogenic factors and the development of atopic dermatitis. Materials and methods: Data were searched in the electronic libraries of scientific articles PubMed, eLIBRARY.RU, and Google Scholar. A total of 41 publications corresponding to the objectives of the current review were analyzed. Results: Numerous studies highlight the dual contribution of exogenous (environmental) and endogenous (internal) factors in the etiology of atopic dermatitis. Psychogenic elements, particularly psychological stress, emerge as key drivers influencing disease progression. Recent advancements in psychoneuroimmunology underscore the profound effect of psychophysiological variables on immune responses. Additionally, a correlation exists between the degree of pathological changes, distribution of skin lesions, and the severity of associated psychopathological manifestations. However, these findings predominantly focus on adults, with less exploration into pediatric populations where mental health aspects are often overlooked. Current investigations typically prioritize cutaneous pathologies rather than considering broader implications related to systemic impacts. Conclusion: Further investigation into the interplay between psychogenic influences and individual personality traits could provide valuable insights into the mechanisms underpinning atopic dermatitis. Addressing the gaps in our knowledge concerning the contributions of intrinsic neurological anomalies and their consequences on autonomic-nervous and immunological balance may yield more effective diagnostic tools and therapies

Background: The problem of atopic dermatitis has received significant attention from researchers across different fields over the years. Despite its high prevalence, there remains an incomplete understanding of the underlying pathogenetic mechanisms, leading to ineffective therapeutic strategies. This lack of consensus regarding a unified model of dermatitis development creates challenges in selecting appropriate treatment options. The aim of the study: To analyze the current scientific literature data describing the relationship between central nervous system damage, psychogenic factors and the development of atopic dermatitis. Materials and methods: Data were searched in the electronic libraries of scientific articles PubMed, eLIBRARY.RU, and Google Scholar. A total of 41 publications corresponding to the objectives of the current review were analyzed. Results: Numerous studies highlight the dual contribution of exogenous (environmental) and endogenous (internal) factors in the etiology of atopic dermatitis. Psychogenic elements, particularly psychological stress, emerge as key drivers influencing disease progression. Recent advancements in psychoneuroimmunology underscore the profound effect of psychophysiological variables on immune responses. Additionally, a correlation exists between the degree of pathological changes, distribution of skin lesions, and the severity of associated psychopathological manifestations. However, these findings predominantly focus on adults, with less exploration into pediatric populations where mental health aspects are often overlooked. Current investigations typically prioritize cutaneous pathologies rather than considering broader implications related to systemic impacts. Conclusion: Further investigation into the interplay between psychogenic influences and individual personality traits could provide valuable insights into the mechanisms underpinning atopic dermatitis. Addressing the gaps in our knowledge concerning the contributions of intrinsic neurological anomalies and their consequences on autonomic-nervous and immunological balance may yield more effective diagnostic tools and therapies

atopic dermatitismental disorders in atopic dermatitisthe mechanism of their occurrenceliterature reviewatopic dermatitismental disorders in atopic dermatitisthe mechanism of their occurrenceliterature reviewСписок литературыCork MJ, Danby SG, Ogg GS. Atopic dermatitis epidemiology and unmet need in the United Kingdom. Journal of Dermatological Treatment. 2020;31(8):801-809. DOI: https://doi.org/10.1080/09546634.2019.1655137Bylund S, von Kobyletzki LB, Svalstedt M, et al. Prevalence and Incidence of Atopic Dermatitis: A Systematic Review. Acta Dermato-Venereologica. 2020;100(12):adv00160. DOI: https://doi.org/10.2340/00015555-3510Kern C, Wan J, LeWinn KZ, et al. Association of Atopic Dermatitis and Mental Health Outcomes Across Childhood: A Longitudinal Cohort Study. JAMA Dermatology. 2021;157(10):1200-1208. DOI: https://doi.org/10.1001/jamadermatol.2021.2657Nedoszytko B, Reszka E, Gutowska-Owsiak D, et al. Genetic and Epigenetic Aspects of Atopic Dermatitis. International Journal of Molecular Sciences. 2020;21:6484. DOI: https://doi.org/10.3390/ijms21186484Martin MJ, Estrav&iacute;s M, Garc&iacute;a-S&aacute;nchez A, et al. Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review. Genes. 2020;11(4):442. DOI: https://doi.org/10.3390/genes11040442Ahn K, Kim BE, Kim J, et al. Recent advances in atopic dermatitis. Current Opinion in Immunology. 2020;66:14-21. DOI: https://doi.org/10.1016/j.coi.2020.02.007Alkotob SS, Cannedy C, Harter K, et al. Advances and novel developments in environmental influences on the development of atopic diseases. Allergy. 2020;75(12):3077-3086. DOI: https://doi.org/10.1111/all.14624H&uuml;lp&uuml;sch C, Weins AB, Traidl-Hoffmann C, et al. A new era of atopic eczema research: Advances and highlights. Allergy. 2021;76(11):3408-3421. DOI: https://doi.org/10.1111/all.15058Levine H. Beneath the Skin: Mental Health and Atopic Dermatitis [Internet]. 2023 [cited 2025 March 25]. Available from: https://www.webmd.com/skin-problems-and-treatments/eczema/mental-health-atopic-dermatitisMac Giollabhui&nbsp; N, Ng TH, Ellman&nbsp; LM, et al. The longitudinal associations of inflammatory biomarkers and depression revisited: systematic review, meta-analysis, and meta-regression. Molecular Psychiatry. 2021;26:3302-3314. DOI: https://doi.org/10.1038/s41380-020-00867-4Boutin RCT, Sbihi H, Dsouza M, et al. Mining the infant gut microbiota for therapeutic targets against atopic disease. Allergy. 2020;75(8):2065-2068. DOI: https://doi.org/10.1111/all.14244Toppila-Salmi S, Chanoine S, Karjalainen J, et al. Risk of adult-onset asthma increases with the number of allergic multimorbidities and decreases with age. Allergy. 2019;74(12):2406-2416. DOI: https://doi.org/10.1111/all.13971Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. The Lancet. 2020;396(10274):345-360. DOI: https://doi.org/10.1016/S0140-6736(20)31286-1Sroka-Tomaszewska J, Trzeciak M. Molecular Mechanisms of Atopic Dermatitis Pathogenesis. International Journal of Molecular Sciences. 2021;22(8):4130. DOI: https://doi.org/10.3390/ijms22084130Kim J, Kim BE, Leung DYM. Pathophysiology of atopic dermatitis: Clinical implications. Allergy and Asthma Proceedings. 2019;40(2):84-92. DOI: https://doi.org/10.2500/aap.2019.40.4202Murashkin NN, Namazova-Baranova LS, Opratin LA, et al. Biologic Therapy of Moderate and Severe Forms of Atopic Dermatitis in Children. Current Pediatrics. 2020;19(6):432-443. Russ. DOI: https://doi.org/10.15690/vsp.v19i6.2145Yosipovitch G, Berger T, Fassett MS. Neuroimmune interactions in chronic itch of atopic dermatitis. Journal of the European Academy of Dermatology and Venereology. 2020;34(2):239-250. DOI: https://doi.org/10.1111/jdv.15973Venter C, Meyer RW, Nwaru BI, et al. EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis. Allergy. 2019;74(8):1429-1444. DOI: https://doi.org/10.1111/all.13764Torres T, Ferreira EO, Gon&ccedil;alo M, et al. Update on Atopic Dermatitis. Acta Medica Portuguesa. 2019;32:606-613. DOI: https://doi.org/10.20344/amp.11963Bakhtilin VYa, Toropova NP. Bioelectric activity of the brain according to electroencephalography in children with atopic dermatitis. New medical technologies in helping children of the Sverdlovsk region. Sbornik nauchno-prakticheskih rabot, posvjashhennyh 50-letiju Oblastnoj detskoj klinicheskoj bol&#39;nicy № 1. Ekaterinburg; 2007. Russian.Huang IH, Chung WH, Wu PC, et al. JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review. Frontiers in Immunology. 2022;8(13):1068260. DOI: https://doi.org/10.3389/fimmu.2022.1068260Silverberg JI. Comorbidities and the impact of atopic dermatitis. Annals of Allergy, Asthma and Immunology. 2019;123:144-151. DOI: https://doi.org/10.1016/j.anai.2019.04.020Muzzolon M,&nbsp; Muzzolon SRB, Lima M, et al. Mental disorders and atopic dermatitis in children and adolescents. Advances in Dermatology and Allergology. 2021;38:1099-1104. DOI: https://doi.org/10.5114/ada.2021.112280Teixeira C, Garcia MJ, Freitas A, et al. Impact of Atopic Dermatitis on the Mental Health of Adolescents&mdash;Literature Review. Medical Sciences Forum. 2022;16(1):8. DOI: https://doi.org/10.3390/msf2022016008Ballardini N, Kramer MS, Oken E, et al. Associations of atopic dermatitis and asthma with child behaviour: results from the PROBIT cohort. Clinical and Experimental Allergy. 2019;49(9):1235-1244. DOI: https://doi.org/10.1111/cea.13417Shakoei S, Atefi N, Rohaninasab M, et al. The association between attention-deficit/hyperactivity disorder and Atopic dermatitis: A study among iranian children. Indian Journal of Dermatology. 2019;64:451-455. DOI: https://doi.org/10.4103/ijd.IJD_458_18Thyssen JP, Hamann CR, Linneberg A, et al. A. Atopic dermatitis is associated with anxiety, depression, and suicidal ideation, but not with psychiatric hospitalization or suicide. Allergy. 2018;73(1):214‑220. DOI: https://doi.org/10.1111/all.13231Solomon I, Ilie MA, Draghici C, et al. The impact of lifestyle factors on evolution of atopic dermatitis: An alternative approach. Experimental and Therapeutic Medicine. 2019;17(2):1078-1084. DOI: https://doi.org/10.3892/etm.2018.6980Sur M, Boca A, Ilies R. Correlation between quality of life and disease severity of pediatric patients with atopic dermatitis. Experimental and Therapeutic Medicine. 2020;20(6):189. DOI: https://doi.org/10.3892/etm.2020.9319Lada G, Talbot PS,&nbsp; Bewley A,&nbsp; et al. Mental health and dermatology practice in the COVID-19 pandemic. Clinical and Experimental Dermatology. 2020;45(7):816-817. DOI: https://doi.org/10.1111/ced.14330Xu X, van Galen LS, Koh MJA, et al. Factors influencing quality of life in children with atopic dermatitis and their caregivers: A cross-sectional study. Scientific Reports. 2019;9:15990. DOI: https://doi.org/10.1038/s41598-019-51129-5Kyung Y, Lee JS, Lee JH, et al. Health-related behaviors and mental health states of South Korean adolescents with atopic dermatitis. Journal of Dermatology. 2020;47(7):699-706. DOI: https://doi.org/10.1111/1346-8138.15386Barbarot S, Auziere S, Gadkari A, et al. Epidemiology of atopic dermatitis in adults: Results from an international survey. Allergy. 2018;73(6):1284-1293. DOI: https://doi.org/10.1111/all.13401Harter K, Hammel G, Krabiell L, et al. Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study. International Archives of Allergy and Immunology. 2019;179(4):262-272. DOI: https://doi.org/10.1159/000499042Kubanov AA. Organization and results of medical care in the field of dermatovenerology in the Russian Federation. Results of 2018. Vestnik dermatologii i venerologii. 2019;95(4):8-23. Russian.Kowalska-Oledzka E, Czarnecka M, Baran A. Epidemiology of atopic dermatitis in Europe. Journal of Drug Assessment. 2019;8(1):126-128. DOI: https://doi.org/10.1080/21556660.2019.1619570Mortz CG, Andersen KE, Poulsen LK, et al. Atopic diseases and type I sensitization from adolescence to adulthood in an unselected population (TOACS) with focus on predictors for allergic rhinitis. Allergy. 2019;74(2):308-317. DOI: https://doi.org/10.1111/all.13630Kruglova LS, Gensler EM. Atopic dermatitis: new horizons of therapy. Medical alphabet. 2019;1(7):29-32. Russian. DOI: https://doi.org/10.33667/2078-5631-2019-1-7(382)-29-32Sandhu JK, Wu KK, Bui TL. Association Between Atopic Dermatitis and Suicidality. JAMA Dermatology. 2019;155(2):178-187. DOI: https://doi.org/10.1001/jamadermatol.2018.4566Fishbein AB, Tilley C, Begolka WS, et al. Sleep Disturbance in School-Aged Children with Atopic Dermatitis: Prevalence and Severity in a Cross-Sectional Sample. Journal of Allergy and Clinical Immunology In Practice. 2021;9(8):3120-3129. DOI: https://doi.org/10.1016/j.jaip.2021.04.064Keller W, Vogel M, Prenzel F, et al.&nbsp; Atopic diseases in children and adolescents are associated with behavioural difficulties. BMC Pediatrics. 2021;21:197. DOI: https://doi.org/10.1186/s12887-021-02663-7