2658-6533Research Results in Biomedicine2658-653310.18413/2313-8955-2015-1-4-19-24489Medicine (miscellaneous)PHARMACOLOGICAL CORRECTION OF IMMUNE DISORDERS IN PATIENTS WITH CHRONIC HEART FAILURE AND ISCHEMIC HEART DISEASEPHARMACOLOGICAL CORRECTION OF IMMUNE DISORDERS IN PATIENTS WITH CHRONIC HEART FAILURE AND ISCHEMIC HEART DISEASEOsipovaOl'ga А.OsipovaOl'ga А.OOsipova@gnicpm.ruDrapkinaOksana M.DrapkinaOksana M.drapkina@bk.ruKulikovskiiVladimir F.KulikovskiiVladimir F.kulikovsky@bsu.edu.ruYaroshAlina Al.YaroshAlina Al.yarosha78@yandex.ruOsipovPavel G.OsipovPavel G.osipov@bsu.edu.ruKletkinaAlina S.KletkinaAlina S.PlaksinaKseniya G.PlaksinaKseniya G.Kseniyalistig@inbox.ru20151400

Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptors.

Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptors.

Immune inflammationchronic heart failurecoronary heart diseasetumor necrosis factor-αß-blockersangiotensin-converting enzyme inhibitorsImmune inflammationchronic heart failurecoronary heart diseasetumor necrosis factor-αß-blockersangiotensin-converting enzyme inhibitorsСписок литературыVoloshina I.N. Dynamics of the cytokine profile in hypertensive patients during carvedilol treatment / Tauride Medical and Biological Bulletin. 2011. Vol. 14. No. 1 (53).Dudarenko O.P. Inhibitor of synthesis of tumor necrosis factor-a, pentoxifylline, in combined therapy of the chronic heart failure / Dudarenko O.P., Shkolnik E.L., Kulikov K.G., Serova M.K., Vasiuk Iu.A.// RFK. 2008. 2. Pp. 6-12Zhelnov V.V. ACE inhibitors in clinical practice / Zhelnov V.V., Petrovskaia N.V., Komarova I.S.// Russian Medical Journal. 2007. 15 (15). Pp. 1135-1141Kokorin V.A. Neurohumoral impairments and methods of their correction in patients suffering the myocardial infarction / Kokorin V.A., Volov N.A., Dudareva A.V., Sytnik N.V., Geng Haischu // Russian Journal of Cardiology. 2009. 1 (75) Makkonen C.F. The content of inflammatory cytokines and C-reactive protein in patients with chronic heart failure with systolic and diastolic dysfunction of the left ventricle of the heart / Makkonen C.F., Suiazova S.B., Osipova O.A., Vlasenko M.A., Godlevskaia O.M., Butikova E.A., Vlasenko O.A.// Journal of Basic Research. Medical sciences. 2012. P. 7 Mareev V.Iu. Diagnosis and treatment of chronic heart failure / Ageev F.T., Arutyunov G.P., Koroteev A.V., Revishvili A.Sh..// Heart failure. 2010. Vol.11. No.1: P. 57Olbinskaia L.I. The use of bisoprolol as anti-cytokine agent / Olbinskaia L.I., Ignatenko S.B. //I.M. Sechenov MMU, 2004.Osipova O.A. Analysis of the importance of pro-inflammatory cytokines in the pathogenic mechanisms of progression of chronic heart failure / Osipova O.A. // System analysis and management in biomedical systems. 2013. Vol. 12. No. 3. Pp. 638-642.Osipova O.A. Analysis of the immunoinflammatory mechanisms in the development and progression of chronic heart failure / Osipova O.A., Nagibina A.I., Vlasenko M.A., Godlevskaia O.M.// System analysis and management in biomedical systems. 2014. Vol. 13. No. 1. Pp. 21-25. Osipova O.A. Humoral mechanisms of chronic heart failure in patients with postinfarctioncardiosclerosis / Osipova O.A., Vlasenko O.A.// Scientific journal of Belgorod State University. Series: Medicine. Pharmacy. 2011. Vol. 14. No.10. Pp. 77-80.Osipova O.A. Role of proinflammatory cytokines in the development of chronic heart failure / Osipova O.A., Suiazova S.B., Vlasenko M.A., Godlevskaia O.M. // Academician I.P. Pavlov Russian medico-biological bulletin. 2013. No. 2. Pp. 130-135.Osipova O.A. Cytokines in the development and progression of chronic heart failure / Osipova O.A., Vlasenko M.A., Godlevskaia O.M., Suiazova S.B.// Bulletin of new medical technologies. 2012. Vol. 19. No. 2. Pp. 322-327.Pribylova N.N. Neurohumoral mechanisms of chronic heart failure in patients with postinfarction cardiosclerosis / Pribylova N.N., Osipova O.A. // «Heart Failure» Journal. 2009. Vol. 10. No. 4. Pp. 196-198.Romanovskaia G.A. Prospects for medical treatment of endothelial dysfunction / Romanovskaia G.A., Akatova E.V., Gorokhovskaia G.N., Avetian N.G., Martyn A.I.// Pharmateka Journal. 2005. 9.Shilov A.M. Carvedilol in the treatment of cardiovascular diseases / Shilov A.M., Miller M.V. // Russian Medical Journal. 2007 9: Pp. 736-742.Shushliapin O.I. Effect of carvedilol on patients with heart failure and type 2 diabetes as polymorbidity pathology in internal medicine / Shushliapin O.I., Kozhin M.I., Dobrovolskaia I.N., Zolotaikina V.I., Titova A.Iu.,Rynchak P.I. // Medicines of Ukraine. 2014. No. 3 (20),Anker SD, Chua TP, Swan JW. Circulation 199. 96: 526- 34.Kolls, J. et al. Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer/ Proc.Natl.Acad.Sci.USA. 1994. 91(1):215-. 9.Levine B., Kalman J., Mayer I., et al. Elevated circulating level of tumor necrosis factor in severe chronic heart failure. New Engl.J.Med. 1990. 223: 236-241.Osipova O.A. Dynamics of proinflammatory cytokines on the background of drug therapy in patients with chronic heart failure /Osipova O.A., Belousova O.N., Ephremova O.A., Suyazova S.B., Shabanov E.A., Godlevskaya O.M.// International Journal of Experimental Education. 2013. No. 6. P. 44-46.Osipova O.A.The level of cytokines in the blood of patients with st-elevation acute myocardial infarction Osipova O.A., Suyasova S.B., Shekhovtsova L.V., Nagibina A.I., Vlasenko M.A., Vlasenko O.A.European Journal of Natural History. 2014. № 5. Р. 31-32.Peppel,K. et al. A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity/ J.Exp.Med.- 1991. 174(6):1483-9. Peppel,K. et al. Expression of a TNF inhibitor in transgenic mice/ J.Immunol. 1993. 151(10):5699-703.