To date, there are many drugs to treat infectious diseases of the eye on the Russian pharmaceutical market, but they have a number of disadvantages, which lead to a decrease in therapeutic efficacy of the formulation. One of these shortcomings is the lack of long-acting in ophthalmic drugs with antimicrobial activity, whereby the drug is quickly washed away tears from the conjunctival cavity. It is essential that the drug was in the conjunctiva quite a long time and could provide the desired therapeutic effect, as excessive tearing promotes rapid washout of drugs and thereby reduces the effectiveness of treatment. In prolonged medicines increased duration of action. Solve maintain high viscosity eye drops, the problem with a minimum content prolongator allows the creation of new or modifications of known adjuvants. One of the promising methods is a modification mechanochemical treatment substances, in particular solid-state processing in mills of different types. The idea of creating new targeted drugs with the use of innovative technologies Mechanochemistry based on the presence in the composition of dosage forms of the complex of active ingredients that influence the different pathogenetic links of the pathological process, and submikrostrukturing prolongators-thickeners providing an optimum mode of instillation and, as a consequence, rational pharmacotherapy.