The main method of prevention and treatment of intoxication processes is the method of enterosorption. Medical clay is a promising group of enterosorbents. There are no dosage forms of medical clays on the basis of the substance of domestic production in Russia. The article presents the stages of development of the technology of solid dosage forms «granules with the adsorption action» based on montmorillonite clay. The authors developed 13 model compounds of granules and determined their technological characteristics and adsorption activity. The experimental studies of a number of excipients and model compounds showed that the model with polyvinyl alcohol possesses the greatest extent of the requirements imposed to the technological requirements of the granules and adsorption activity. The results of biopharmaceutical studies in vitro experiments on determination of adsorption activity showed that the adsorption activity of the granules in the model stomach was 57.3±0.3 mg/g, the model intestine of 58.9±0.2 mg/g. In the environment of the stomach and the environment of the intestine, there was observed a high adsorption activity, but at higher temperatures and shift the pH to the acid side, there was observed a decrease in adsorption activity. The obtained data is entered into the project of technological rules for medicinal product «medical granules montmorillonite clay with adsorptive action».