2658-6533Research Results in Biomedicine2658-653310.18413/2313-8955-2016-2-4-108-114944Archive categoriesTHE STUDY OF BIOPHARMACEUTICAL PROPRETIES OF NANOFIBERS FOR THE TREATMENT OF VIRAL CONJUNCTIVITESTHE STUDY OF BIOPHARMACEUTICAL PROPRETIES OF NANOFIBERS FOR THE TREATMENT OF VIRAL CONJUNCTIVITESBaskakovaAlexandra V.BaskakovaAlexandra V.ZhilyakovaElena T.ZhilyakovaElena T.ezhilyakova@bsu.edu.ruVasilyevGeorgy V.VasilyevGeorgy V.vasilyev@bsu.edu.ru20162400

Two series of fibers containing the active ingredients acyclovir, ciprofloxacin and cyanocobalamin, and combinations of these drugs, were prepared by electrospinning. One set was used as a hydrophilic poly(vinylpyrrolidone) (PVP) filament-forming polymer, while the other – poly (e-caprolactone) (PCL) – was used as a slow-dissolving polymer. The drug release from various fibers was tested in a validated in vitro outflow model of the eye, and the fiber formulations were found to be capable of extending the drug release. Thus we conclude that electrospun matrices, such as those prepared in this work, have a potential for use as intravitreal implants.

Two series of fibers containing the active ingredients acyclovir, ciprofloxacin and cyanocobalamin, and combinations of these drugs, were prepared by electrospinning. One set was used as a hydrophilic poly(vinylpyrrolidone) (PVP) filament-forming polymer, while the other – poly (e-caprolactone) (PCL) – was used as a slow-dissolving polymer. The drug release from various fibers was tested in a validated in vitro outflow model of the eye, and the fiber formulations were found to be capable of extending the drug release. Thus we conclude that electrospun matrices, such as those prepared in this work, have a potential for use as intravitreal implants.

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