2658-6533Research Results in Biomedicine2658-653310.18413/2313-8955-2017-3-1-8-14993Medicine (miscellaneous)RELATIONSHIP BETWEEN INSULIN-LIKE GROWTH FACTOR-1 AND INDICATORS OF THE CARBOHYDRATE METABOLISM IN PATIENTS WITH COMORBIDITY OF ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUSRELATIONSHIP BETWEEN INSULIN-LIKE GROWTH FACTOR-1 AND INDICATORS OF THE CARBOHYDRATE METABOLISM IN PATIENTS WITH COMORBIDITY OF ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUSPyvovarovAlexander V.PyvovarovAlexander V.20173100

Relevance. Insulin and insulin-like growth factor-1 are regarded as a single signal system that regulates the metabolism and processes of cell growth and differentiation. Despite the known mechanisms of the effect of insulin-like growth factor-1, there are still some unclear issues regarding somatomedin participation in the regulation of carbohydrate metabolism in patients with hypertension and in patients with concomitant hypertension and over with type 2 diabetes mellitus. Studying the role of insulin-like growth factor-1 in the pathogenesis of type 2 diabetes mellitus is an urgent problem that requires further investigation. Problem. The author studies the correlations between the level of insulin-like growth factor - 1 in the blood and indicators of the state of carbohydrate metabolism. Materials and methods. A total of 120 people, including 100 patients with cardiological and endocrinological problems, and 20 healthy subjects in the control group. The first group included 60 patients with hypertension, the second - 40 patients with combined pathology of hypertension and type 2 diabetes mellitus. The researches determined the level of blood sugar on an empty stomach, the level of insulin, glycosylated hemoglobin, insulin-like growth factor-1, and calculated the HOMA-IR index. Results. The highest average level of insulin-like growth factor-1 in blood was observed in patients with a concomitant course of hypertension and type 2 diabetes mellitus. All selected groups observed a direct correlation between the level of insulin-like growth factor-1 in the blood and the value of the HOMA-ІR index. The highest value of the correlation coefficient turned out to be in the second group of patients with a concomitant course of hypertension and type 2 diabetes mellitus. Conclusions. It was found that the detection of high levels of insulin-like growth factor-1 in the blood allows to set the risk of progression of disorders of the carbohydrate metabolism in hypertensive patients in the early stages, thereby increasing the effectiveness of an early diagnosis of type 2 diabetes mellitus.

Relevance. Insulin and insulin-like growth factor-1 are regarded as a single signal system that regulates the metabolism and processes of cell growth and differentiation. Despite the known mechanisms of the effect of insulin-like growth factor-1, there are still some unclear issues regarding somatomedin participation in the regulation of carbohydrate metabolism in patients with hypertension and in patients with concomitant hypertension and over with type 2 diabetes mellitus. Studying the role of insulin-like growth factor-1 in the pathogenesis of type 2 diabetes mellitus is an urgent problem that requires further investigation. Problem. The author studies the correlations between the level of insulin-like growth factor - 1 in the blood and indicators of the state of carbohydrate metabolism. Materials and methods. A total of 120 people, including 100 patients with cardiological and endocrinological problems, and 20 healthy subjects in the control group. The first group included 60 patients with hypertension, the second - 40 patients with combined pathology of hypertension and type 2 diabetes mellitus. The researches determined the level of blood sugar on an empty stomach, the level of insulin, glycosylated hemoglobin, insulin-like growth factor-1, and calculated the HOMA-IR index. Results. The highest average level of insulin-like growth factor-1 in blood was observed in patients with a concomitant course of hypertension and type 2 diabetes mellitus. All selected groups observed a direct correlation between the level of insulin-like growth factor-1 in the blood and the value of the HOMA-ІR index. The highest value of the correlation coefficient turned out to be in the second group of patients with a concomitant course of hypertension and type 2 diabetes mellitus. Conclusions. It was found that the detection of high levels of insulin-like growth factor-1 in the blood allows to set the risk of progression of disorders of the carbohydrate metabolism in hypertensive patients in the early stages, thereby increasing the effectiveness of an early diagnosis of type 2 diabetes mellitus.

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