2658-6533Research Results in Biomedicine2658-653310.18413/2313-8955-2017-3-1-15-23994Medicine (miscellaneous)ENDOCRINE COMPONENT OF EARLY ONCOLOGIC PATHOLOGY IN EXPERIMENTAL CANCER OF BOWELSENDOCRINE COMPONENT OF EARLY ONCOLOGIC PATHOLOGY IN EXPERIMENTAL CANCER OF BOWELSFaustovLeonid A.FaustovLeonid A.SychevaNatalia L.SychevaNatalia L.20173100

The authors studied the neurosecretory hypothalamo-hypophyseal system and ductless glands in the latent period of experimental colon cancer caused by 1.2-dimethylhydrazin. For the first time, in an experimental bowel carcinogenesis, there was characterized an endocrine component of early cancer pathology, which is a complex of morphological changes in the neurosecretory hypothalamo-hypophyseal system and ductless glands. It was found that the morphological changes characteristic of endocrine constancy over different periods of the studied latent period, and are independent of the applied dose of carcinogen. Consequently, in the latent period of carcinogenesis of the bowel, a newly developed hormonal status maintains at a certain level. This complex of endocrine changes is a reflection of a new hormonal balance of the body, which is a necessary attribute of the formation of cancer. The study confirmed the morphogenetic mechanism of de novo for experimental bowel cancer when exposed to 1.2-dimethylhydrazin. Our studies show that the intestinal tumor morphological substrate of the disease in the latent period includes the identified complex structural changes in the endocrine and neuroendocrine system that is involved in the formation of tumor and its further progression. The revealed structural complex of endocrine changes expands and deepens our understanding of the morphological substrate of precancerous changes in the body during the formation of de novo colon cancer in the absence of local precancerous morphological changes in the intestinal mucosa. Our results can be the basis for the development of measures for the diagnosis of neoplastic disease long before the appearance of a malignant tumor in the intestines.

The authors studied the neurosecretory hypothalamo-hypophyseal system and ductless glands in the latent period of experimental colon cancer caused by 1.2-dimethylhydrazin. For the first time, in an experimental bowel carcinogenesis, there was characterized an endocrine component of early cancer pathology, which is a complex of morphological changes in the neurosecretory hypothalamo-hypophyseal system and ductless glands. It was found that the morphological changes characteristic of endocrine constancy over different periods of the studied latent period, and are independent of the applied dose of carcinogen. Consequently, in the latent period of carcinogenesis of the bowel, a newly developed hormonal status maintains at a certain level. This complex of endocrine changes is a reflection of a new hormonal balance of the body, which is a necessary attribute of the formation of cancer. The study confirmed the morphogenetic mechanism of de novo for experimental bowel cancer when exposed to 1.2-dimethylhydrazin. Our studies show that the intestinal tumor morphological substrate of the disease in the latent period includes the identified complex structural changes in the endocrine and neuroendocrine system that is involved in the formation of tumor and its further progression. The revealed structural complex of endocrine changes expands and deepens our understanding of the morphological substrate of precancerous changes in the body during the formation of de novo colon cancer in the absence of local precancerous morphological changes in the intestinal mucosa. Our results can be the basis for the development of measures for the diagnosis of neoplastic disease long before the appearance of a malignant tumor in the intestines.

early oncologic pathologybowel cancerendocrine morphological complexneuroendocrine systemearly oncologic pathologybowel cancerendocrine morphological complexneuroendocrine systemСписок литературыDavydovskiy I.V. Total human pathology. 2nd ed., Rev. and ext.. M., Meditsina 1969. 612 p.Es'kov M.N. About the method of studying the human hypothalamus. Archive of pathology. 1969. 31 (1). Pp. 80-81.Merkulov G.A. A course of the pathological and histological technology. L., Meditsina. 1969. 423 p.Nikishaev V.I. The Endoscopic Diagnostics of Early Colorectal Cancer. Ukrainian Journal of minimally invasive and endoscopic surgery. 2012. 16(1). Pp. 35-55.Oyvin I.F. Statistical analysis of experimental results. Pathological Physiology and Experimental Therapy. 1960. 4. Pp. 76-85.Pal'tsev M.A., Serov V.V. Pathological anatomy and its place among the medical and biological sciences. In: Pathological anatomy. Lecture Course: a training manual. Pod red., M.A. Pal'tseva. M, Meditsina. 1998. Pp. 5-11.Peterson B.E. Problems of early cancer. Oncology questions. 1980. 26 (11). Pp. 117-118.Pirs E. Histochemistry Theoretical and Applied. M., IL. 1962. 962 p.Pozharisskiy K.M. Morphogenesis of experimental intestinal tumors. Oncology questions. 1974. 20 (19). Pp. 83-90.Pozharisskiy K.M., Savost'yanov G.A. Ultrastructural characteristics of experimental intestinal tumors. Oncology questions. 1976. 22(1). Pp. 59-68.Pozharisskiy K.M. Modern understanding of precancer. In: General Oncology. L., Meditsina. Pp. 193-213.Raskin G.A., Petrov S.V., Orlova R.V. Special features of carcinogenesis of colon adenocarcinoma. Siberian Journal of Oncology. 2015. 4. Pp. 73-79.Romeys B. The microscopic technique. M., IL. 1954. 718 p.Sarkisov D.S. Molecular pathology and the problem of the body's integrity. Archive of pathology. 1976. 38(4). Pp. 3-12.Sycheva N.L., Faustov L.A. Methods of histological and histochemical clinical treatment (biopsy) of the material. In: Chronic generalized periodontitis. Krasnodar, Prosveshchenie-Yug. 2012. Pp.101-103.Faustov L.A. Methods of quantifying some histochemical components in the adrenal cortex. In: Histochemistry in normal and pathological morphology. ed. M.Ya. Subbotina. Novosibirsk, Nauka. 1967. Pp. 391-392.Faustov L.A. Fundamentals of Clinical Pathomorphology. 2-e izd., pererab. i dop. Krasnodar: KMI. 2014. 398 p.Faustov L.A., Pavlenko S.G., Sycheva N.L., Nabatova O.S., Ivanovskii S.O., Fizulin M.M. Optimization of complex treatment of patients with colorectal cancer. Krasnodar, KMI. 2015. 226 p.Faustov L.A. Pathological anatomy of the endocrine glands in different periods of experimental carcinogenesis (histopathological, histochemical and morphometric study). Avtoref. dis. … Doctor of Medical Sciences. Moskva. 1980. 32 p.Faustov L.A., Sycheva N.L. A new aspect in the study of precancer. In: Questions of theoretical and clinical medicine. Krasnodar. 2006. Pp. 172-177.Faustov L.A. The experimental bowel carcinogenesis. In: Current problems of surgical gastroenterology. Kursk. 1975. Pp. 172-174.Kuramoto S., Oohara T. Minute cancers arising de novo in the human large intestine. Cancer. 1988. 61. Pp. 829-834.Kuramoto S., Oohara T. Flat early cancers of the large intestine. Cancer. 1989. 64. Pp. 950-955.Shimoda T., Ikegami M., Fujisaki J., Matsui T., Aizawa S., Ishikawa E., Early colorectal carcinoma with special reference to its development de novo. Cancer. 1989. 64 (5). Pp. 1138-1146.