2658-6533Научные результаты биомедицинских исследований2658-653310.18413/2313-8955-2018-4-4-0-41596Фармакология, клиническая фармакологияPerspective materials for drug delivery in the ophthalmic dosage form: a short review of polymers for electrospinningPerspective materials for drug delivery in the ophthalmic dosage form: a short review of polymers for electrospinningBaskakovaAlexandra V.BaskakovaAlexandra V.aleksbaskakova@yandex.ru20184400

Background: The traditional ophthalmological dosage forms have a low bioavailability, a rapid precorneal clearance and a low corneal permeability. The gelling system or system with a prolonged action (prolonged eye-drops) may be overcome by the application of fibers. An innovative dosage form was described for ophthalmology and perspective drug development. The authors also conducted an overview of the polymers investigated in the production of films or tablets for oral dosage forms. The properties of fibers revealed fundamental differences from polymers. Combining different properties of pharmaceutical formulations appears to offer a synergy in bioavailability and sustained release with very comfortable conditions of use and prolonged action. Novel formulations, such as prolonged eye-drops and gels or thinnest films for the eye, will be developed and tested in vitro studies. This enhancement stipulates for perspective pharmaceutical development. The aim of the study: To describe the main types of fibers for the development of a potential ophthalmological dosage form. Materials and methods: The review of the articles with high CiteScore rating in Scopus and Web of Science. CiteScore is a simple way of measuring the citation impact of sources. Tasks: to describe suitable polymers for development of ocular dosage forms prepared by electrospinning. Results: The results of the review of the most useful polymers show that in most cases all polymers are used together. A huge number of ophthalmologic pathologies call for a correct approach to each nosology in each case. Conclusion: The electrospinning method will stipulate for the future development of customized tools for the treatment of ophthalmic pathologies. The development of an ophthalmic insert with the possible introduction of several medicinal substances depending on the condition of each patient is promising.

Background: The traditional ophthalmological dosage forms have a low bioavailability, a rapid precorneal clearance and a low corneal permeability. The gelling system or system with a prolonged action (prolonged eye-drops) may be overcome by the application of fibers. An innovative dosage form was described for ophthalmology and perspective drug development. The authors also conducted an overview of the polymers investigated in the production of films or tablets for oral dosage forms. The properties of fibers revealed fundamental differences from polymers. Combining different properties of pharmaceutical formulations appears to offer a synergy in bioavailability and sustained release with very comfortable conditions of use and prolonged action. Novel formulations, such as prolonged eye-drops and gels or thinnest films for the eye, will be developed and tested in vitro studies. This enhancement stipulates for perspective pharmaceutical development. The aim of the study: To describe the main types of fibers for the development of a potential ophthalmological dosage form. Materials and methods: The review of the articles with high CiteScore rating in Scopus and Web of Science. CiteScore is a simple way of measuring the citation impact of sources. Tasks: to describe suitable polymers for development of ocular dosage forms prepared by electrospinning. Results: The results of the review of the most useful polymers show that in most cases all polymers are used together. A huge number of ophthalmologic pathologies call for a correct approach to each nosology in each case. Conclusion: The electrospinning method will stipulate for the future development of customized tools for the treatment of ophthalmic pathologies. The development of an ophthalmic insert with the possible introduction of several medicinal substances depending on the condition of each patient is promising.

nanofiberselectrospinningophthalmologypolymerselectrospun formulationsocular formulationPVPPEOPVACDsPDSChitosanCellulosenanofiberselectrospinningophthalmologypolymerselectrospun formulationsocular formulationPVPPEOPVACDsPDSChitosanCelluloseСписок литературыBaskakova A, Awwad S, Jiménez JQ, et al. Electrospun formulations of acyclovir, ciprofloxacin and cyanocobalamin for ocular drug delivery. Int J Pharm. 2016 Apr 11;502(1-2):208-18. DOI: https://doi.org/10.1016/j.ijpharm.2016.02.015Meireles AB, Corrêa DK, da Silveira JV, et al. Trends in polymeric electrospun fibers and their use as oral biomaterials. J Exp Biol Med (Maywood). 2018 May;243(8):665-676. DOI: https://doi.org/10.1177/1535370218770404Battistella E, Varoni E, Cochis A, et al. Degradable polymers may improve dental practice. J Appl Biomater Biomech. 2011;9:223-31. DOI: https://doi.org/10.5301/JABB.2011.8867Xiao Y, Gong T, Jiang Y, et al. Fabrication and characterization of a glucose-sensitive antibacterial chitosan-polyethylene oxide hydrogel. J Polymer. 2016;82:1-10. DOI: https://doi.org/10.1016/j.polymer.2015.11.016Kim GM, Asran AS, Michler GH, et al. Electrospun PVA/HAp nanocomposite nanofibers: biomimetics of mineralized hard tissues at a lower level of complexity. J Bioinspir Biomim. 2008;3:046003.Bottino MC, Yassen GH, Platt JA, et al. A novel three dimensional scaffold for regenerative endodontics: materials and biological characterizations. J Tissue Eng Regen Med. 2015;9:116-23. DOI: https://doi.org/10.1002/term.1712Furuya DC, Costa SA, Oliveira RC, et al. Fibers obtained from alginate, chitosan and hybrid used in the development of scaffolds. J Mat Res. 2017;20:377-86. DOI: http://dx.doi.org/10.1590/1980-5373-mr-2016-0509Ao C, Niu Y, Zhang X, et al. Fabrication and characterization of electrospun cellulose/nano-hydroxyapatite nanofibers for bone tissue engineering. Int J Biol Macromol. 2017;97:568-73. DOI: https://doi.org/10.1016/j.ijbiomac.2016.12.091Karataş A, Algan AH, Pekel-Bayramgil N, et al. Ofloxacin Loaded Electrospun Fibers for Ocular Drug Delivery: Effect of Formulation Variables on Fiber Morphology and Drug Release. J Curr Drug Deliv. 2016;13(3):433-43.Simões SM, Veiga F, Torres-Labandeira JJ, et al. Syringeable self-assembled cyclodextrin gels for drug delivery. J Curr Top Med Chem. 2014;14(4):494-509.Hu QD, Tang GP, Chu PK. Cyclodextrin-based host-guest supramolecular nanoparticles for delivery: from design to applications. Acc Chem Res. 2014 Jul 15;47(7):2017-25. DOI: 10.1021/ar500055sCostoya A, Concheiro A, Alvarez-Lorenzo C. Electrospun Fibers of Cyclodextrins and Poly(cyclodextrins). Molecules. 2017 Feb 3;22(2).Aydogdu A, Sumnu G, Sahin S. A novel electrospun hydroxypropyl methylcellulose/polyethylene oxide blend nanofibers: Morphology and physicochemical properties. J Carbohydr Polym. 2018 Feb 1;181:234-246. DOI: https://doi.org/10.1016/j.carbpol.2017.10.071Kuang G, Zhang Z, Liu S, et al. Biomater Sci. Biphasic drug release from electrospun polyblend nanofibers for optimized local cancer treatment. 2018 Jan 30;6(2):324-331. DOI: 10.1039/C7BM01018DBai Y, Zhang J, Chen X. A Thermal-, Water-, and Near-Infrared Light-Induced Shape Memory Composite Based on Polyvinyl Alcohol and Polyaniline Fibers ACS Appl Mater Interfaces. 2018 Apr 25;10(16):14017-14025. DOI: 10.1021/acsami.8b01425Karczewski A, Feitosa SA, Hamer EI, et al.Clindamycin-modified Triple Antibiotic Nanofibers: A Stain-free Antimicrobial Intracanal Drug Delivery System. J Endod. 2018 Jan;44(1):155-162. DOI: https://doi.org/10.1016/j.joen.2017.08.024