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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2658-6533</journal-id><journal-title-group><journal-title>Научные результаты биомедицинских исследований</journal-title></journal-title-group><issn pub-type="epub">2658-6533</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.18413/2658-6533-2024-10-1-0-8</article-id><article-id pub-id-type="publisher-id">3339</article-id><article-categories><subj-group subj-group-type="heading"><subject>Клиническая медицина</subject></subj-group></article-categories><title-group><article-title>&lt;strong&gt;Роль негативного детского опыта и внутренней стигмы в формировании мотивации к лечению пациентов с психическими расстройствами&lt;/strong&gt;</article-title><trans-title-group xml:lang="en"><trans-title>&lt;strong&gt;The role of negative childhood experiences and internal stigma in the formation of motivation for the treatment of patients with mental disorders&lt;/strong&gt;</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Герасимчук</surname><given-names>Екатерина Сергеевна</given-names></name><name xml:lang="en"><surname>Gerasimchuk</surname><given-names>Ekaterina S.</given-names></name></name-alternatives><email>katherine.gerasimchuk@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Сорокин</surname><given-names>Михаил Юрьевич</given-names></name><name xml:lang="en"><surname>Sorokin</surname><given-names>Mikhail Yu.</given-names></name></name-alternatives><email>m.sorokin@list.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Лутова</surname><given-names>Наталия Борисовна</given-names></name><name xml:lang="en"><surname>Lutova</surname><given-names>Natalia B.</given-names></name></name-alternatives><email>lutova@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Портениер</surname><given-names>Сергей Николаевич</given-names></name><name xml:lang="en"><surname>Portenier</surname><given-names>Sergey N.</given-names></name></name-alternatives><email>bekhterev_nii_2otd@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Горбунова</surname><given-names>Ольга Васильевна</given-names></name><name xml:lang="en"><surname>Gorbunova</surname><given-names>Olga V.</given-names></name></name-alternatives><email>rybka200@mail.ru</email></contrib></contrib-group><pub-date pub-type="epub"><year>2024</year></pub-date><volume>10</volume><issue>1</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/medicine/2024/1/Биомед_исслед-127-143_испр.7.02.2024.pdf" /><abstract xml:lang="ru"><p>Актуальность: Мотивация к лечению является важным компонентом приверженности пациентов к терапии психического расстройства, при этом на ее формирование могут оказывать влияние различные факторы. Цель исследования: Проанализировать взаимосвязи негативного детского опыта, внутренней стигмы с интенсивностью и структурой мотивации к фармако-психотерапии у пациентов психиатрического профиля. Материалы и методы: В исследовании приняли участие 102 пациента, находившихся на лечении в НМИЦ ПН имени. В.М. Бехтерева, СПб ГБУЗ &amp;laquo;Больница им. П.П. Кащенко&amp;raquo;, СПб ГКУЗ &amp;laquo;Городская психиатрическая больница №6&amp;raquo;. Были использованы: опросник неблагоприятного детского опыта Adverse Childhood Experience (ACE); опросник интернализованной стигмы психического расстройства (ISMI) и опросник оценки мотивации к лечению (ОцМЛ). Статистический анализ проводился с использованием пакета программного обеспечения SPSS 26.0. Результаты: По результатам множественного регрессионного анализа наличие высшего образования детерминировало улучшение мотивации к лечению пациентов, в 5,92 раза повышая вероятность ее высокой интенсивности. Наличие каждого дополнительного вида негативного опыта в детском возрасте также в 1,4 раза повышало шансы интенсивной мотивации больных. Среди отдельных вариантов негативного опыта эмоциональное насилие было ассоциировано с десятикратным снижением шансов, а наблюдение насилия в адрес матери или мачехи в детстве, наоборот было связано с пятнадцатикратным повышением шансов формирования интенсивной мотивации к лечению. Заключение: Интегративный вклад негативного детского опыта имеет ключевое значение, однако, в отличие от внутренней стигмы психического расстройства, может быть в равной степени связан как с более, так и менее адаптивными мотивационными моделями у пациентов в ходе их лечения</p></abstract><trans-abstract xml:lang="en"><p>Background: Motivation for treatment is an important component of patients&amp;#39; compliance to treatment of mental disorders, and its formation can be affected by different factors. The aim of the study: To analyze relationship between adverse childhood experiences, internal stigma and the intensity and structure of motivation to pharmaco-psychotherapy in patients with mental disorders. Materials and methods: The study involved 102 patients treated at the V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, the Kashchenko Hospital, and the City Psychiatric Hospital No. 6. The study used the Adverse Childhood Experience (ACE) questionnaire, the Internalized Stigma of Mental Illness (ISMI) questionnaire, and the Treatment Motivation Assessment Questionnaire (TIMQ). Statistical analysis was performed using the SPSS 26.0 software package. Results: According to the results of multiple regression analysis, patients with higher education determined the improvement of patients&amp;#39; motivation for treatment, increasing the probability of its high intensity by 5.92 times. The presence of each additional type of adverse experience in childhood also 1.4-fold increase the odds of intensive motivation of patients. Among individual variants of negative experience, emotional abuse was associated with a tenfold decrease in odds, while observing violence against a mother or stepmother in childhood was conversely associated with a fifteenfold increase in the odds of forming an intense motivation for treatment. Conclusion: Integrative role of adverse childhood experiences is important, but, unlike the internal stigma of mental disorder, it can be equally associated with both less adaptive motivational patterns during treatment. to both more and less adaptive motivational patterns in patients in the process of their treatment</p></trans-abstract><kwd-group xml:lang="ru"><kwd>негативный детский опыт</kwd><kwd>НДО</kwd><kwd>психологическая травма</kwd><kwd>детский травматический опыт</kwd><kwd>приверженность лечению и комплайенс</kwd><kwd>вовлеченность пациента</kwd><kwd>мотивация</kwd><kwd>психические расстройства</kwd><kwd>стигма</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adverse childhood experience</kwd><kwd>ACE</kwd><kwd>psychological trauma</kwd><kwd>childhood traumatic experience</kwd><kwd>treatment adherence and compliance</kwd><kwd>patient engagement</kwd><kwd>motivation</kwd><kwd>mental disorders</kwd><kwd>stigma</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>Всемирная организация здравоохранения [Электронный ресурс] [дата обращения 30.12.2022]. 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