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<article article-type="research-article" dtd-version="1.2" xml:lang="ru" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><front><journal-meta><journal-id journal-id-type="issn">2658-6533</journal-id><journal-title-group><journal-title>Научные результаты биомедицинских исследований</journal-title></journal-title-group><issn pub-type="epub">2658-6533</issn></journal-meta><article-meta><article-id pub-id-type="doi">10.18413 / 2313-8955-2015-1-1-81-85</article-id><article-id pub-id-type="publisher-id">403</article-id><article-categories><subj-group subj-group-type="heading"><subject>Архив</subject></subj-group></article-categories><title-group><article-title>ПОДХОД К ДИАГНОСТИКЕ ФИБРОЗА ПЕЧЕНИ: СЫВОРОТОЧНЫЕ МАРКЕРЫ</article-title><trans-title-group xml:lang="en"><trans-title>APPROACH TO DIAGNOSIS OF LIVER FIBROSIS: SERUM MARKERS REVIEW</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Журавлёва</surname><given-names>Анна Константиновна</given-names></name><name xml:lang="en"><surname>Zhuravleva</surname><given-names>Anna K.</given-names></name></name-alternatives><email>vnmed3@gmail.com</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Огнева</surname><given-names>Елена Валентиновна</given-names></name><name xml:lang="en"><surname>Ogneva</surname><given-names>Elena V.</given-names></name></name-alternatives></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="ru"><surname>Журавлёва</surname><given-names>Лариса Владимировна</given-names></name><name xml:lang="en"><surname>Zhuravlyova</surname><given-names>Larysa V.</given-names></name></name-alternatives><email>prof.zhuravlyova@gmail.com</email></contrib></contrib-group><pub-date pub-type="epub"><year>2015</year></pub-date><volume>1</volume><issue>1</issue><fpage>0</fpage><lpage>0</lpage><self-uri content-type="pdf" xlink:href="/media/medicine/2015/1/81-85.pdf" /><abstract xml:lang="ru"><p>Фиброз печеночной ткани является завершающей стадией развития различных заболеваний печени. Первоначально считалось, что фиброз необратим, но в настоящее время уже известно, что это динамический процесс, имеющий значительный потенциал для обратного развития. Своевременная диагностика фиброза печени может предотвратить возникновение нежелательных осложнений. Традиционно диагностика и количественное определение фиброзированной ткани основывались на биопсии печени. Но у пункционной биопсии существует целый ряд недостатков, ограничивающих проведение этой процедуры. В данной статье рассматриваются современные методы оценки фиброза печени, основанные на определении сывороточных маркеров.</p></abstract><trans-abstract xml:lang="en"><p>Hepatic fibrosis is the final stage of many disorders of the liver. Originally, hepatic fibrosis was considered irreversible, however, hepatic fibrosis is now known to be a dynamic process with a significant potential for resolution. Timely diagnosis of liver fibrosis can prevent development of unwanted complications. The diagnosis and quantitation of fibrosis have traditionally relied on liver biopsy. However, there are a number of drawbacks that limit its use. This article reviews the current methods of assessment of hepatic fibrosis based on the serum markers.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фиброз печени</kwd><kwd>сывороточные маркеры</kwd></kwd-group><kwd-group xml:lang="en"><kwd>fibrosis of liver</kwd><kwd>serum markers</kwd></kwd-group></article-meta></front><back><ref-list><title>Список литературы</title><ref id="B1"><mixed-citation>Diarmuid S. Diagnosis and Quantification of fibrosis/ Diarmuid S. Manning, Nezam H. Afdhal// Gastroenterology; 2008; vol. 134, issue 6. Pp. 1670-1681</mixed-citation></ref><ref id="B2"><mixed-citation>William M.C. Serum markers detect the presence of liver fibrosis: A cohort study/ William M.C. Rosenberg, Michael Voelker, Robert Thiel etc.// Gastroenterology; 2012; vol. 127, issue 6. 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