DOI: 10.18413/2658-6533-2025-11-1-0-2

Взаимосвязь мобильных генетических элементов с некодирующими РНК в развитии атеросклероза (обзор)

Рустам Наилевич Мустафин
Эльза Камилевна Хуснутдинова

Актуальность: Атеросклероз является ведущей причиной сердечно-сосудистой патологии взрослого населения всего мира. Ассоциация болезни с возрастом свидетельствует о наличии общих механизмов развития старения и атеросклероза. В научной литературе появляется все больше данных о роли некодирующих РНК и мобильных генетических элементов в механизмах старения и атеросклероза. Поиск молекулярных механизмов болезни на эпигенетическом уровне позволит разрабатывать новые методы терапии. Цель исследования: Определить роль транспозонов и некодирующих РНК в этиопатогенезе атеросклероза и их взаимосвязь между собой в данных процессах. Материалы и методы: Использованы базы данных Scopus, WoS, PubMed для анализа роли микроРНК, длинных некодирующих РНК, транспозонов в развитии старения и атеросклероза. Результаты: Согласно проанализированной литературе, важным фактором развития атеросклероза является патологическая активация транспозонов при старении, вызывающая интерфероновый ответ и асептическое воспаление в организме, в том числе в стенках сосудов. Определена роль эпигенетических факторов, в этиопатогенезе атеросклероза, включая микроРНК и длинные некодирующие РНК, которые изменяют экспрессию специфических генов в макрофагах, гладкомышечных клетках сосудов и эндотелиоцитах. Активация транспозонов отражается в изменении экспрессии произошедших от них в эволюции или образующихся при процессинге их транскриптов длинных некодирующих РНК и микроРНК. Анализ научной литературы позволил обнаружить 64 произошедших от транспозонов микроРНК, изменения экспрессии которых характерны для атеросклероза. Из 64 выявленных микроРНК 34 ассоциированы со старением, что свидетельствует о роли патологически активированных при старении транспозонов в инициации развития атеросклероза. Заключение: Поскольку транспозоны являются драйверами эпигенетической регуляции в онтогенезе, полученные результаты впервые в научной литературе описывают наиболее вероятные механизмы влияния механизмов старения на развитие атеросклероза на эпигенетическом уровне. Это обусловлено патологической активацией транспозонов с возрастом, что оказывает влияние на изменение экспрессии произошедших от них некодирующих РНК за счет наличия комплементарных последовательностей и участия в общих эпигенетических сетях регуляции функционирования генома. Полученные данные о роли произошедших от транспозонов микроРНК в развитии как атеросклероза, так и старения, подтверждают предложенные механизмы патогенеза болезни.

Ключевые слова: атеросклероз, воспаление, длинные некодирующие РНК, микроРНК, старение, транспозоны.

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Мустафин РН, Хуснутдинова ЭК. Взаимосвязь мобильных генетических
элементов с некодирующими РНК в развитии атеросклероза (обзор). Научные результаты
биомедицинских исследований. 2025;11(1):31-56. [Mustafin RN, Khusnutdinova EK. Relationship of transposable elements with non coding RNAs in the development of atherosclerosis (review). Research Results in Biomedicine. 2025;11(1):31-56. Russian].DOI:10.18413/2658-6533-2025-11-1-0-2

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de Yebenes VG, Briones AM, Martos-Folgado I, et al. Aging-Associated miR-217 Aggravates Atherosclerosis and Promotes Cardiovascular Dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology. 2020;40(10):2408-2424. DOI: https://doi.org/10.1161/ATVBAHA.120.314333
Gorbunova V, Seluanov A, Mita P, et al. The role of retrotransposable elements in ageing and age-associated diseases. Nature. 2021;596:43-53. DOI: https://doi.org/10.1038/s41586-021-03542-y
de Cecco M, Ito T, Petrashen AP, et al. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature. 2019;566(7742):73-78. DOI: https://doi.org/10.1038/s41586-018-0784-9
Russ E, Mikhalkevich N, Iordanskiy S. Expression of Human Endogenous Retrovirus Group K (HERV-K) HML-2 Correlates with Immune Activation of Macrophages and Type I Interferon Response. Microbiology Spectrum. 2023;11(2):e0443822. DOI: https://doi.org/10.1128/spectrum.04438-22
Laderoute MP. The paradigm of immunosenescence in atherosclerosis-cardiovascular disease (ASCVD). Discovery Medicine. 2020;29(156):41-51.
Matsuzawa A, Lee J, Nakagawa S, et al. HERV-Derived Ervpb1 Is Conserved in Simiiformes, Exhibiting Expression in Hematopoietic Cell Lineages Including Macrophages. International Journal of Molecular Sciences. 2021;22(9):4504. DOI: https://doi.org/10.3390/ijms22094504
Mustafin RN, Khusnutdinova E. Perspective for studying the relationship of miRNAs with transposable elements. Current Issues in Molecular Biology. 2023;45(4):3122-3145. DOI: https://doi.org/ 10.3390/cimb45040204
Rivera-Munoz P, Malivert L, Derdouch S, et al. DNA repair and the immune system: From V(D)J recombination to aging lymphocytes. European Journal of Immunology. 2007;37(S1):S71-S82. DOI: https://doi.org/10.1002/eji.200737396
Chuong EB, Elde NC, Feschotte C. Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science. 2016;351(6277):1083-1087. DOI: https://doi.org/10.1126/science.aad5497
Yang H, Sun Y, Li Q, et al. Diverse Epigenetic Regulations of Macrophages in Atherosclerosis. Frontiers in Cardiovascular Medicine. 2022;9:868788. DOI: https://doi.org/10.3389/fcvm.2022.868788
Мустафин РН. Перспективы применения статинов в противовирусной терапии. Клиническая микробиология и антимикробная химиотерапия. 2023;25(1):56-67. DOI: https://doi.org/10.36488/cmac.2023.1.56-67
Badarinarayan SS, Sauter D. Switching Sides: How Endogenous Retroviruses Protect Us from Viral Infections. Journal of Virology. 2021;95(12):e02299-20. DOI: https://doi.org/10.1128/JVI.02299-20
Мустафин РН, Хуснутдинова ЭК. Некодирующие части генома как основа эпигенетической наследственности. Вавиловский журнал генетики и селекции. 2017;21(6):742-749. DOI: https://doi.org/10.18699/10.18699/VJ17.30-o
Menghini R, Stohr R, Federici M. MicroRNAs in vascular aging and atherosclerosis. Ageing Research Reviews. 2014;17:68-78. DOI: https://doi.org/10.1016/j.arr.2014.03.005
Lu Y, Thavarajah T, Gu W, et al. Impact of miRNA in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018;38(9):e159-e170. DOI: https://doi.org/10.1161/ATVBAHA.118.310227
Chen C, Yan Y, Liu X. microRNA-612 is downregulated by platelet-derived growth factor-BB treatment and has inhibitory effects on vascular smooth muscle cell proliferation and migration via directly targeting AKT2. Experimental and Therapeutic Medicine. 2018;15(1):159-165. DOI: https://doi.org/10.3892/etm.2017.5428
Simion V, Zhou H, Haemming S, et al. A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. Nature Communications. 2020;11:6135. DOI: https://doi.org/10.1038/s41467-020-19664-2
Bai J, Liu J, Fu Z, et al. Silencing lncRNA AK136714 reduces endothelial cell damage and inhibits atherosclerosis. Aging. 2021;13(10):14159-14169. DOI: https://doi.org/10.18632/aging.203031
Chi JS, Li JZ, Jia JJ, et al. Long non-coding RNA ANRIL in gene regulation and its duality in atherosclerosis. Current Medical Science. 2017;37:816-822. DOI: https://doi.org/10.1007/s11596-017-1812-y
Vlachogiannis NI, Sachse M, Georgiopoulos G, et al. Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease. Journal of Molecular and Cellular Cardiology. 2021;160:111-120. DOI: https://doi.org/10.1016/j.yjmcc.2021.07.005
Ye ZM, Yang S, Xia Y, et al. LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation. Cell Death and Disease. 2019;10:138. DOI: https://doi.org/10.1038/s41419-019-1409-4
Wei G, Qin S, Li W, et al. MDTE DB: a database for microRNAs derived from Transposable element. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2016;13(6):1155-1160. DOI: https://doi.org/10.1109/TCBB.2015.2511767
Sorrentino TA, Duong P, Bouchareychas L, et al. Circulating exosomes from patients with peripheral artery disease influence vascular cell migration and contain distinct microRNA cargo. JVS-Vascular Science. 2020;1:28–41. DOI: https://doi.org/10.1016/j.jvssci.2020.02.001
Pan D, Liu G, Li B, et al. MicroRNA-1246 regulates proliferation, invasion, and differentiation in human vascular smooth muscle cells by targeting cystic fibrosis transmembrane conductance regulator (CFTR). Pflugers Archiv European Journal of Physiology. 2021;473:231-240. DOI: https://doi.org/10.1007/s00424-020-02498-8
Hooten NN, Fitzpatrick M, Wood WH, et al. Age-related changes in microRNA levels in serum. Aging. 2013;5(10):725-740. DOI: https://doi.org/10.18632/aging.100603
Lin FY, Tsai YT, Huang CY, et al. GroEL of Porphyromonas gingivalis-induced microRNAs accelerate tumor neovascularization by downregulating thrombomodulin expression in endothelial progenitor cells. Molecular Oral Microbiology. 2023;39(2):47-61. DOI: https://doi.org/10.1111/omi.12415
Wang YQ, Xu XM, Wang XL, et al. LncRNA FOXC2-AS1 regulated proliferation and apoptosis of vascular smooth muscle cell through targeting miR-1253/FOXF1 axis in atherosclerosis. European Review for Medical and Pharmacological Sciences. 2020;24:3302-3314. DOI: https://doi.org/10.26355/eurrev_202003_20698
Xu X, Li H. Integrated microRNA-gene analysis of coronary artery disease based on miRNA and gene expression profiles. Molecular Medicine Reports. 2016;13(4):3063-3073. DOI: https://doi.org/10.3892/mmr.2016.4936
Tan KS, Armugam A, Sepramaniam S, et al. Expression profile of microRNAs in young stroke patients. PLoS ONE. 2009;4:e7689. DOI: https://doi.org/10.1371/journal.pone.0007689
Wen Y, Chun Y, Lian ZQ, et al. circRNA‑0006896‑miR1264‑DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis. Molecular Medicine Reports. 2021;23(5):311. DOI: https://doi.org/10.3892/mmr.2021.11950
Long R, Gao L, Li Y, et al. M2 macrophage-derived exosomes carry miR-1271-5p to alleviate cardiac injury in acute myocardial infarction through down-regulating SOX6. Molecular Immunology. 2021;136:26-35. DOI: https://doi.org/10.1016/j.molimm.2021.05.006
Wang R, Dong LD, Meng XB, et al. Unique MicroRNA signatures associated with early coronary atherosclerotic plaques. Biochemical and Biophysical Research Communications. 2015;464(2):574-579. DOI: https://doi.org/10.1016/j.bbrc.2015.07.010
Ma W, Wei D, Li X, et al. CircPCNX Promotes PDGF-BB-Induced Proliferation and Migration of Human Aortic Vascular Smooth Muscle Cells Through Regulating miR-1278/DNMT1 Axis. Cardiovascular Drugs and Therapy. 2023;37:877-889. DOI: https://doi.org/10.1007/s10557-022-07342-y
Niu M, Li H, Li X, et al. Circulating Exosomal miRNAs as Novel Biomarkers Perform Superior Diagnostic Efficiency Compared With Plasma miRNAs for Large-Artery Atherosclerosis Stroke. Frontiers in Pharmacology. 2021;12:791644. DOI: https://doi.org/10.3389/fphar.2021.791644
Xu D, Liu T, He L, et al. LncRNA MEG3 inhibits HMEC-1 cells growth, migration and tube formation via sponging miR-147. Biological Chemistry. 2020;401(5):601-615. DOI: https://doi.org/10.1515/hsz-2019-0230
Chen F, Ye X, Jiang H, et al. MicroRNA-151 Attenuates Apoptosis of Endothelial Cells Induced by Oxidized Low-density Lipoprotein by Targeting Interleukin-17A (IL-17A). Journal of Cardiovascular Translational Research. 2021;14:400-408. DOI: https://doi.org/10.1007/s12265-020-10065-w
Zhao L, Wang B, Sun L, et al. Association of miR-192-5p with Atherosclerosis and its Effect on Proliferation and Migration of Vascular Smooth Muscle Cells. Molecular Biotechnology. 2021;63:1244-1251. DOI: https://doi.org/10.1007/s12033-021-00376-x
Zhang Y, Wang H, Xia Y. The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis. BMC Cardiovascular Disorders. 2021;21:371. DOI: https://doi.org/10.1186/s12872-021-02187-z
Miller CL, Haas U, Diaz R, et al. Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genetics. 2014;10:e1004263. DOI: https://doi.org/10.1371/journal.pgen.1004263
Liu J, Liu Y, Sun YN, et al. miR-28-5p Involved in LXR-ABCA1 Pathway is Increased in the Plasma of Unstable Angina Patients. Heart, Lung and Circulation. 2015;24(7):724-730. DOI: https://doi.org/10.1016/j.hlc.2014.12.160
Arora M, Kaul D, Sharma YP. Human coronary heart disease: importance of blood cellular miR-2909 RNomics. Molecular and Cellular Biochemistry. 2014;392:49-63. DOI: https://doi.org/10.1007/s11010-014-2017-3
Liu D, Sun X, Ye P. miR-31 Overexpression Exacerbates Atherosclerosis by Targeting NOX4 in apoE(-/-) Mice. Clinical Laboratory. 2015;61(11):1617-1624. DOI: https://doi.org/10.7754/clin.lab.2015.150322
Hildebrandt A, Kirchner B, Meidert AS, et al. Detection of Atherosclerosis by Small RNA-Sequencing Analysis of Extracellular Vesicle Enriched Serum Samples. Frontiers in Cell and Developmental Biology. 2021;9:729061. DOI: https://doi.org/10.3389/fcell.2021.729061
Lu X, Yang B, Yang H, et al. MicroRNA-320b Modulates Cholesterol Efflux and Atherosclerosis. Journal of Atherosclerosis and Thrombosis. 2022;29(2):200-220. Chinese. DOI: https://doi.org/10.5551/jat.57125
Pu Y, Zhao Q, Men X, et al. MicroRNA-325 facilitates atherosclerosis progression by mediating the SREBF1/LXR axis via KDM1A. Life Sciences. 2021;277:119464. DOI: https://doi.org/10.1016/j.lfs.2021.119464
Wang L, Zheng Z, Feng X, et al. circRNA/lncRNA-miRNA-mRNA Network in Oxidized, Low-Density, Lipoprotein-Induced Foam Cells. DNA and Cell Biology. 2019;38:1499-1511. DOI: https://doi.org/10.1089/dna.2019.4865
Schiano C, Benincasa G, Franzese M, et al. Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases. Pharmacology and Therapeutics. 2020;210:107514. DOI: https://doi.org/10.1016/j.pharmthera.2020.107514
Ahmadi R, Heidarian E, Fadaei R, et al. miR-342-5p Expression Levels in Coronary Artery Disease Patients and its Association with Inflammatory Cytokines. Clinical Laboratory. 2018;64:603-609. DOI: https://doi.org/10.7754/Clin.Lab.2017.171208
Fan JL, Zhang L, Bo XH. MiR-126 on mice with coronary artery disease by targeting S1PR2. European Review for Medical and Pharmacological Sciences. 2020;24:893-904. DOI: https://doi.org/10.26355/eurrev_202001_20074
Wang W, Ma F, Zhang H. MicroRNA-374 is a potential diagnostic biomarker for atherosclerosis and regulates the proliferation and migration of vascular smooth muscle cells. Cardiovascular Diagnosis and Therapy. 2020;10(4):687-694. DOI: https://doi.org/10.21037/cdt-20-444
Shao D, Lian Z, Di Y, et al. Dietary compounds have potential in controlling atherosclerosis by modulating macrophage cholesterol metabolism and inflammation via miRNA. Npj Science of Food. 2018;2:13. DOI: https://doi.org/10.1038/s41538-018-0022-8
Wang B, Zhong Y, Huang D, et al. Macrophage autophagy regulated by miR-384-5p-mediated control of Beclin-1 plays a role in the development of atherosclerosis. American Journal of Translational Research. 2016;8(2):606-614.
Yang J, Liu H, Cao Q, et al. Characteristics of CXCL2 expression in coronary atherosclerosis and negative regulation by microRNA-421. Journal of International Medical Research. 2020;48:300060519896150. DOI: https://doi.org/10.1177/0300060519896150
He Z, Xue H, Liu P, et al. miR-4286/TGF-β1/Smad3-Negative Feedback Loop Ameliorated Vascular Endothelial Cell Damage by Attenuating Apoptosis and Inflammatory Response. Journal of Cardiovascular Pharmacology. 2020;75(5):446-454. DOI: https://doi.org/10.1097/FJC.0000000000000813
Wang X, Li H, Zhang Y, et al. Suppression of miR-4463 promotes phenotypic switching in VSMCs treated with Ox-LDL. Cell and Tissue Research. 2021;383:1155-1165. DOI: https://doi.org/10.1007/s00441-020-03338-y
Liang X, Hu M, Yuan W, et al. MicroRNA-4487 regulates vascular smooth muscle cell proliferation, migration and apoptosis by targeting RAS p21 protein activator 1. Pathology - Research and Practice. 2022;234:153903. DOI: https://doi.org/10.1016/j.prp.2022.153903
Ye F, Zhang J, Zhang Q, et al. Preliminary study on the mechanism of long noncoding RNA SENCR regulating the proliferation and migration of vascular smooth muscle cells. Journal of Cellular Physiology. 2020;235(12):9635-9643. DOI: https://doi.org/10.1002/jcp.29775
Wang WL, Chen LJ, Wei SY, et al. Mechanoresponsive Smad5 Enhances MiR-487a Processing to Promote Vascular Endothelial Proliferation in Response to Disturbed Flow. Frontiers in Cell and Developmental Biology. 2021;9:647714. DOI: https://doi.org/10.3389/fcell.2021.647714
Rafiq M, Dandare A, Javed A, et al. Competing Endogenous RNA Regulatory Networks of hsa_circ_0126672 in Pathophysiology of Coronary Heart Disease. Genes. 2023;14(3):550. DOI: https://doi.org/10.3390/genes14030550
Liu Z, Yin X, Mai H, et al. SCD rs41290540 single-nucleotide polymorphism modifies miR-498 binding and is associated with a decreased risk of coronary artery disease. Molecular Genetics and Genomic Medicine. 2020;8(3):e1136. DOI: https://doi.org/10.1002/mgg3.1136
Wang J, Pei Y, Zhong Y, et al. Altered serum microRNAs as novel diagnostic biomarkers for atypical coronary artery disease. PLoS ONE. 2014:9:e107012. DOI: https://doi.org/10.1371/journal.pone.0107012
Karragiannis GS, Weile J, Bader GD, et al. Integrative pathway dissection of molecular mechanisms of moxLDL-induced vascular smooth muscle phenotype transformation. BMC Cardiovascular Disorders. 2013;13:4. DOI: https://doi.org/10.1186/1471-2261-13-4
Salerno AG, van Solingen C, Scotti E, et al. LDL Receptor Pathway Regulation by miR-224 and miR-520d. Frontiers in Cardiovascular Medicine. 2020;7:81. DOI: https://doi.org/10.3389/fcvm.2020.00081
Guo J, Xiang Q, Xin Y, et al. miR-544 promotes maturity and antioxidation of stem cell-derived endothelial like cells by regulating the YY1/TET2 signalling axis. Cell Communication and Signaling. 2020;18:35. DOI: https://doi.org/10.1186/s12964-019-0504-6
Konwerski M, Gromadka A, Arendarczyk A, et al. Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue of Patients with Coronary Artery Disease. Journal of Inflammation Research. 2021;14:5419-5431. DOI: https://doi.org/10.2147/JIR.S326769
Fang M, Zhou Q, Tu W, et al. ATF4 promotes brain vascular smooth muscle cells proliferation, invasion and migration by targeting miR-552-SKI axis. PLoS ONE. 2022;17:e0270880. DOI: https://doi.org/10.1371/journal.pone.0270880
Zhao X, Yi Y, Meng C, et al. MiRNA-575 suppresses angiogenesis by targeting Rab5-MEK-ERK pathway in endothelial cells. Bioscience Reports. 2019;39:BSR20181218. DOI: https://doi.org/10.1042/BSR20181218
Zhang M, Zhu Y, Zhu J, et al. circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p. Cellular and Molecular Biology Letters. 2022;27:80. DOI: https://doi.org/10.1186/s11658-022-00372-2
Wang L, Li H, Zheng Z, et al. Hsa_circ_0031891 targets miR-579-3p to enhance HMGB1 expression and regulate PDGF-BB-induced human aortic vascular smooth muscle cell proliferation, migration, and dedifferentiation. Naunyn-Schmiedeberg's Archives of Pharmacology. 2024;397(2):1093-1104. DOI: https://doi.org/10.1007/s00210-023-02663-7
Kim TK, Jeon S, Park S, et al. 2'-5' oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability. Nature Communications. 2022;13:6647. DOI: https://doi.org/10.1038/s41467-022-34433-z
Chen H, Song X, Wu Y, et al. Linc-OIP5 working as a ceRNA of miR-616 promotes PON1 expression in HUEVC cells. International Journal of Clinical and Experimental Pathology. 2020;13(4):730-737.
Miao R, Qi C, Fu Y, et al. Silencing of circARHGAP12 inhibits the progression of atherosclerosis via miR-630/EZH2/TIMP2 signal axis. Journal of Cellular Physiology. 2022;237(1):1057-1069. DOI: https://doi.org/10.1002/jcp.30598
Hou X, Dai H, Zheng Y. Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis. Bioengineered. 2022;13:5987-5998. DOI: https://doi.org/10.1080/21655979.2022.2039467
Zhang Z, Qin S, Wang R, et al. Circ_0003575 knockdown alleviates ox-LDL-induced human aortic endothelial cell dysfunction in atherosclerosis by miR-637/TRAF6 axis. Clinical Hemorheology and Microcirculation. 2023;85(2):173-187. DOI: https://doi.org/10.3233/CH-231858
Ma G, Bi S, Zhang P. Long non-coding RNA MIAT regulates ox-LDL-induced cell proliferation, migration and invasion by miR-641/STIM1 axis in human vascular smooth muscle cells. BMC Cardiovascular Disorders. 2021;21:248. DOI: https://doi.org/10.1186/s12872-021-02048-9
Huang R, Hu Z, Cao Y, et al. MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression. EBioMedicine. 2019;40:685-694. DOI: https://doi.org/10.1016/j.ebiom.2019.01.032
Yang Y, Li M, Liu Y, et al. The lncRNA Punisher Regulates Apoptosis and Mitochondrial Homeostasis of Vascular Smooth Muscle Cells via Targeting miR-664a-5p and OPA1. Oxidative Medicine and Cellular Longevity. 2022;2022:5477024. DOI: https://doi.org/10.1155/2022/5477024
Chen LJ, Chuang L, Huang YH, et al. MicroRNA mediation of endothelial inflammatory response to smooth muscle cells and its inhibition by atheroprotective shear stress. Circulation Research. 2015;116(7):1157-1169. DOI: https://doi.org/10.1161/CIRCRESAHA.116.305987
Karere GM, Glenn JP, Li G, et al. Potential miRNA biomarkers and therapeutic targets for early atherosclerotic lesions. Scientific Reports. 2023;13:3467. DOI: https://doi.org/10.1038/s41598-023-29074-1
Caparosa EM, Sedgewick AJ, Zenonos G, et al. Regional Molecular Signature of the Symptomatic Atherosclerotic Carotid Plaque. Neurosurgery. 2019;85(2):E284-E293. DOI: https://doi.org/10.1093/neuros/nyy470
Marasa BS, Srikantan S, Martindale JL, et al. MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging. 2010;2(6):333-343. DOI: https://doi.org/10.18632/aging.100159
Dhahbi JM, Atamna H, Boffelli D, et al. Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence. PLoS ONE. 2011;6:e20509. DOI: https://doi.org/10.1371/journal.pone.0020509
Maes OC, Sarojini H, Wang E. Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts. Journal of Cellular Physiology. 2009;221(1):109-119. DOI: https://doi.org/10.1002/jcp.21834
Tsukamoto H, Kouwaki T, Oshiumi H. Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly. iScience. 2020;23:101520. DOI: https://doi.org/10.1016/j.isci.2020.101520
Smith-Vikos T, Liu Z, Parsons C. A serum miRNA profile of human longevity: findings from the Baltimore Longitudinal Study of Aging (BLSA). Aging. 2016;8(11):2971-2987. DOI: https://doi.org/10.18632/aging.101106
Francisco S, Martinho V, Ferreira M, et al. The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging. International Journal of Molecular Sciences. 2022;23(6):3232. DOI: https://doi.org/10.3390/ijms23063232
Yentrapalli R, Azimzadeh O, Kraemer A, et al. Quantitative and integrated proteome and microRNA analysis of endothelial replicative senescence. Journal of Proteomics. 2015;126:12-23. DOI: https://doi.org/10.1016/j.jprot.2015.05.023
Yu Y, Zhang X, Liu F, et al. A stress-induced miR-31-CLOCK-ERK pathway is a key driver and therapeutic target for skin aging. Nature Aging. 2021;1:795-809. DOI: https://doi.org/10.1038/s43587-021-00094-8
Dalmasso B, Hatse S, Brouwers B, et al. Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy. BMC Cancer. 2018;18:1014. DOI: https://doi.org/10.1186/s12885-018-4920-6
Zhao J, Li C, Qin T, et al. Mechanical overloading-induced miR-325-3p reduction promoted chondrocyte senescence and exacerbated facet joint degeneration. Arthritis Research and Therapy. 2023;25:54. DOI: https://doi.org/10.1186/s13075-023-03037-3
Yang X, Tan J, Shen J, et al. Endothelial Cell-Derived Extracellular Vesicles Target TLR4 via miRNA-326-3p to Regulate Skin Fibroblasts Senescence. Journal of Immunology Research. 2022;2022:3371982. DOI: https://doi.org/10.1155/2022/3371982
Liu Y, Lai P, Deng J, et al. Micro-RNA335-5p targeted inhibition of sKlotho and promoted oxidative stress-mediated aging of endothelial cells. Biomarkers in Medicine. 2019;13:457-466. DOI: https://doi.org/10.2217/bmm-2018-0430
Owczarz M, Polosak J, Domaszewska-Szostek A, et al. Age-related epigenetic drift deregulates SIRT6 expression and affects its downstream genes in human peripheral blood mononuclear cells. Epigenetics. 2020;15(12):1336-1347. DOI: https://doi.org/10.1080/15592294.2020.1780081
Proctor CJ, Goljanek-Whysall K. Using computer simulation models to investigate the most promising microRNAs to improve muscle regeneration during ageing. Scientific Reports. 2017;7:12314. DOI: https://doi.org/10.1038/s41598-017-12538-6
Li X, Wu J, Zhang K, et al. miR-384-5p Targets Gli2 and Negatively Regulates Age-Related Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells. Stem Cells and Development. 2019;28(12):791-798. DOI: https://doi.org/10.1089/scd.2019.0044
Wang L, Si X, Chen S, et al. A comprehensive evaluation of skin aging-related circular RNA expression profiles. Journal of Clinical Laboratory Analysis. 2021;35(4):e23714. DOI: https://doi.org/10.1002/jcla.23714
Li X, Song Y, Liu D, et al. MiR-495 Promotes Senescence of Mesenchymal Stem Cells by Targeting Bmi-1. Cellular Physiology and Biochemistry. 2017;42:780-796. DOI: https://doi.org/10.1159/000478069
Yu M, He X, Liu T, et al. lncRNA GPRC5D-AS1 as a ceRNA inhibits skeletal muscle aging by regulating miR-520d-5p. Aging. 2023;15(23):13980-13997. DOI: https://doi.org/10.18632/aging.205279
Breunig S, Wallner V, Kobler K, et al. The life in a gradient: calcium, the lncRNA SPRR2C and mir542/mir196a meet in the epidermis to regulate the aging process. Aging. 2021;13(15):19127-19144. DOI: https://doi.org/10.18632/aging.203385
Castanheira CIGD, Anderson JR, Fang Y, et al. Mouse microRNA signatures in joint ageing and post-traumatic osteoarthritis. Osteoarthritis and Cartilage Open. 2021;3(4):100186. DOI: https://doi.org/10.1016/j.ocarto.2021.100186

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Учредитель: федеральное государственное автономное образовательное учреждение высшего образования «Белгородский государственный национальный исследовательский университет» (НИУ «БелГУ»). Адрес: 308015, Белгородская область, г. Белгород, ул. Победы, 85.

Издатель: федеральное государственное автономное образовательное учреждение высшего образования «Белгородский государственный национальный исследовательский университет» (НИУ «БелГУ»). Адрес: 308015, Белгородская область, г. Белгород, ул. Победы, 85.

Редакция: главный редактор Малютина Анастасия Юрьевна, e-mail: malyutina_a@bsuedu.ru, тел.: +7 (4722) 30-14-03.

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