THE INVOLVEMENT OF GENES OF MATRIX METALLOPROTEINASES IN THE DEVELOPMENT OF ARTEIAL HYPERTENSION AND ITS COMPLICATION (REVIEW)
Cardiovascular diseases are the leading cause of death and disability in Russia and in the world, and hypertension is considered to be an independent predisposing factor in such complications as myocardial infarction, cerebral stroke, chronic renal failure and aneurysm. The study of the molecular genetic basis of hypertension is an important task of modern medicine and determines the prospects for its personalization. The aim of this review is to generalize the experimental data on genetic associations of matrix metalloproteinases (MMP) gene polymorphisms with the development of arterial hypertension and its complications. Materials and methods. The paper reviews the data on associations of polymorphisms of MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12 with development of hypertension and its complications. The search and analysis of the literature data was carried out using the PubMed-NCBI databases (https: //preview.ncbi.nlm.nih.Gov/pubmed). Results of the study and conclusion. According to the latest data, the genes of matrix metalloproteinases (MMP) are involved in the etiopathogenesis of hypertension. This group of proteolytic enzymes with a wide range of biological functions, which are responsible for the hydrolysis of all components of the extracellular matrix. In the vascular wall, MMPs affect the migration, proliferation and apoptosis of smooth muscle, endothelial and inflammatory cells, thereby determining the formation of intima and arterial remodeling, as evidenced by clinical and transgenic studies. The facts about the role of MMP polymorphic markers in the development of arterial hypertension do not always agree with each other and differ in different populations, which can be explained by differences in the ethnic composition and size of the study groups and the design of the study.
Moskalenko MI. The involvement of genes of matrix metalloproteinases in the development of arteial hypertension and its complication (review). Research Result. Medicine and Pharmacy. 2018;4(1):53-69 (In Russian). DOI: 10.18413/2313-8955-2018-4-1-53-69
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1. Kolomeychuk, S.N., Kornev, V.A., Ilyukha, V.V., Kuznetsov, A.S., Kuznetsova, T.Y. (2014), “ Issledovaniye polimorfnykh variantov gena matriksnoy metalloproteinazy 3 (MMP-3) v kachestve markera riska razvitiya arterial'noy gipertenzii i ishemicheskoy bolezni serdtsa u naseleniya Respubliki Kareliya” [Study of gene polymorphisms of matrix metalloproteinase 3 (MMP-3) as a marker of the risk of hypertension and coronary heart disease in the population of the Republic of Karelia], Zhurnal biomeditsinskikh tekhnologiy, 2, 10-16. Russian.
2. Gavrilyuk, N.D., Irtyuga, O.B., Druzhkova, T.A., Uspenskiy, V.E., Malashicheva, A.B., Kostareva, A.A., Moiseeva, O.V. (2015), “Polimorfizmy genov matriksnykh metalloproteinaz 2 i 9 u patsiyentov s anevrizmoy voskhodyashchego otdela aorty” [Polymorphisms of genes of matrix metalloproteinases 2 and 9 in patients with aneurysm of the ascending aorta], Rossiyskiy kardiologicheskiy zhurnal, 10, 65-69. Russian.
3. Wang, Z., Xu, Y., Chen, S., Wang, L., Ding, H., Lu, G., Wang, D., Zhai, Z., Duan, J., Zhang, W. (2012), “A common missense single nucleotide polymorphism in the E-selectin gene is significantly associated with essential hypertension in the Han population but only weakly associated in the Uygur population”, Hypertens Research, 35(4), 413-417.
4. Jormsjö, S., Whatling, C., Walter, D.H., Zeiher, A.M., Hamsten, A., Eriksson, P. (2011), “Allele-Specific Regulation of Matrix Metalloproteinase-7 Promoter Activity Is Associated With Coronary Artery Luminal Dimensions Among Hypercholesterolemic Patients”, Arteriosclerosis, Thrombosis, and Vascular Biology, 21, 1834-1839.
5. Anthony, D., George, P., Eaton, C.B. (2014), “Cardiac risk factors: biomarkers and genetic tests to determine cardiovascular risk”, FP Essentials, 421, 11-15.
6. Guo, S., Chen, W., Yang, Y., Yang, Z., Cao, M. (2014), “Association between 1019C/T polymorphism in the connexin 37 gene and essential hypertension”, Heart Lung Circ, 23(10), 924-929.
7. Wang X ., Sun, Q., Huang, Y., Hu, Y., Tang, J., Lin, Y., Niu, Y., Wang, X., Du, B. (2013), “Association between CACNB2 gene polymorphisms and essential hypertension”, Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 30(3), 340-344.
8. Wen, D., Du, X., Nie, S.P., Dong, J.Z., Ma, C.S. (2014), “Association between matrix metalloproteinase family gene polymorphisms and ischemic stroke: a meta-analysis”, Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 1834-1839.
9. Hao, Y., Tian, S., Sun, M., Zhu, Y., Nie, Z., Yang, S. (2015), “Association between matrix metalloproteinase gene polymorphisms and development of ischemic stroke”, Int J Clin Exp Pathol, 8(9), 1647-1652.
10. Saratzis, A., Bown, M.J., Wild, B., Nightingale, P., Smith, J., Johnson, C., Melas, N., Kitas, G.D. (2015), “Association between seven single nucleotide polymorphisms involved in inflammation and proteolysis and abdominal aortic aneurysm”, J Vasc Surg, 61(5), 1120-1128.
11. Wu, H.D., Bai, X., Chen, D.M., Cao, H.Y., Qin, L. (2013), “Association of genetic polymorphisms in matrix metalloproteinase-9 and coronary artery disease in the Chinese Han population: a case-control study”, Genet Test Mol Biomarkers, 17(9), 707-712.
12. Yang, W., Lu, J., Yang, L., Zhang, J. (2015), “Association of Matrix Metalloproteinase-9 Gene -1562C/T Polymorphism with Essential Hypertension: A Systematic Review and Meta-Analysis Article”, Iran J Public Health, 44(11), 1445-1452.
13. Mishra, A., Srivastava, A., Mittal, T., Garg, N., Mittal, B. (2012), “Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients”, Clin Chim Acta, 413(19-20), 1668-1674.
14. Bonnans, C., Chou, J., Werb, Z. Bonnans, C. (2014), “Remodelling the extracellular matrix in development and disease”, Nat. Rev. Mol. Cell Biol., 15(12), 786-801.
15. Taljaard, M., Tuna, M., Bennett, C., Perez, R., Rosella, L., Tu, J.V., Sanmartin, C., Hennessy, D., Tanuseputro, P., Lebenbaum, M., Manuel, D.G. (2014), “Cardiovascular Disease Population Risk Tool (CVDPoRT): predictive algorithm for assessing CVD risk in the community setting”, BMJ Open, 4(10), 213-219.
16. Chen, Z.R., Huang, B., Fan, X.H., Lu, H.S., Zhao, Z.H., Hui, R.T., Yang, Y.M., Zhu, J., Zhang, S. (2016), “Clinical characteristics and outcomes of patients with acute aortic dissection: impact of hypertension”, Zhonghua Xin Xue Guan Bing Za Zhi, 44(3), 220-225.
17. Miao, S., Zhou, S.Y., Han, C.S., Zhang, L.N., Sun, H.B., Yang, B. (2015), “Clinicopathological significance of matrix metalloproteinase-7 protein expression in esophageal cancer: a meta-analysis”, Drug Des Devel Ther, 9, 3729-3740.
18. Lacchini, R., Jacob-Ferreira, A.L., Luizon, M.R., Gasparini, S., Ferreira-Sae, M.C., Schreiber, R., Nadruz, W. Jr., Tanus-Santos, J.E. (2012), “Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients”, J Hum Hypertens, 26(3), 171-177.
19. El-Aziz, T.A., Mohamed, R.H. (2016), “Matrix Metalloproteinase 3 Gene Polymorphism and Its Level Predict Morbidity After Acute Myocardial Infarction”, Am J Clin Pathol, 145(1), 134-139.
20. Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Z., Verschuren, M. (2012), “European Guidelines on cardiovascular disease prevention in clinical practice: The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)”, Eur Heart J, 33, 1635-1701.
21. Hoseini, S.M., Kalantari, A., Afarideh, M., Noshad, S., Behdadnia, A., Nakhjavani, M., Esteghamati, A. (2015), “Evaluation of plasma MMP-8, MMP-9 and TIMP-1 identifies candidate cardiometabolic risk marker in metabolic syndrome: results from double-blinded nested case-control study”, Metabolism, 64(4), 527-538.
22. Fields, G.B., Stawikowski, M.J. (2016), “Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression”, Methods Mol Biol, 1406, 303-329.
23. Qintao, C., Yan, L., Changhong, D., Xiaoliang, G., Xiaochen, L. (2014), “Genetic polymorphism of matrix metalloproteinase-1 and coronary artery disease susceptibility: a case-control study in a Han Chinese population”, Genet Test Mol Biomarkers, 18(12), 826-831.
24. Metzger, I.F., Luizon, M.R., Lacchini, R., Tanus-Santos, J.E. (2012), “Genetic variants in matrix metalloproteinase-9 gene modify metalloproteinase-9 levels in black subjects”, DNA Cell Biol, 31(4), 504-510.
25. Chang, T.J., Wang, W.C., Hsiung, C.A., He, C.T., Lin, M.W., Sheu, W.H., Chang, Y.C., Quertermous, T., Chen, I., Rotter, J., Chuang, L.M. (2016), “Genetic Variation in the Human SORBS1 Gene is Associated With Blood Pressure Regulation and Age at Onset of Hypertension: A SAPPHIRe Cohort Study”, Medicine (Baltimore), 95(10), 2970.
26. Wang, F., Jin, X.P., Zhu, M., Lin, X.F., Hu, X.F., Wang, W.F., Han, Z., Huang, L.Z. (2011), “Genotype association of C(-735)T polymorphism of the MMP-2 gene with the risk of carotid atherosclerosis-vulnerable plaque in the Han Chinese population”, Vasc Med, 16(1), 13-18.
27. Hejduk, P., Sakowicz, A., Pietrucha, T. (2015), “Association between ins4436A in 11β-hydroxysteroid dehydrogenase type 1 gene and essential hypertension in Polish population”, Postepy Hig Med Dosw, 69, 1245-1250.
28. Low, S.K., Zembutsu, H., Takahashi, A., Kamatani, N., Cha, P.C., Hosono, N., Kubo, M., Matsuda, K., Nakamura, Y. (2011), “Impact of LIMK1, MMP2 and TNF-α variations for intracranial aneurysm in Japanese population”, J Hum Genet, 56(3), 211-216.
29. Sri Manjari, K., Nallari, P., Balakrishna, N., Vidyasagar, A., Prabhakar, B., Jyothy, A., Venkateshwari, A. (2013), “Influence of matrix metalloproteinase-1 gene -1607 (1G/2G) (rs1799750) promoter polymorphism on circulating levels of MMP-1 in chronic pancreatitis”, Biochem Genet, 51(7-8), 644-654.
30. Liu, X., Meng, F., Yang, P. (2013), “Association study of CD36 single nucleotide polymorphisms with essential hypertension in the Northeastern Han Chinese”, Gene, 527(1), 410-415.
31. Lin, T.H., Yang, S.F., Chiu, C.C., Su, H.M., Wang, C.L., Voon, W.C., Lai, W.T., Sheu, S.H. (2013), “Matrix metalloproteinase-1 mitral expression and -1607 1G/2G gene promoter polymorphism in mitral chordae tendinae rupture”, Transl Res, 161(5), 406-413.
32. Arning, A., Jeibmann, A., Köhnemann, S., Brokinkel, B., Ewelt, C., Berger, K., Wellmann, J., Nowak-Göttl, U., Stummer, W., Stoll, M., Holling, M. (2016), “Matrix metalloproteinase-12 (MMP-12) and the risk of cerebral aneurysm”, J Neurosurg, 8, 1-6.
33. Saeed, H.M., Alanazi, M.S., Parine, N.R., Shaik, J., Semlali, A., Alharbi, O., Azzam, N., Aljebreen, A., Almadi, M., Shalaby, M.A. (2013), “Matrix metalloproteinase-2 (-1306 c>t) promoter polymorphism and risk of colorectal cancer in the Saudi population”, Asian Pac J Cancer Prev, 14(10), 6025-6030.
34. Bahrehmand, F., Vaisi-Raygani, A., Kiani, A., Rahimi, Z., Tavilani, H., Navabi, S.J., Shakiba, E., Hassanzadeh, N., Pourmotabbed, T. (2012), “Matrix metalloproteinase-2 functional promoter polymorphism G1575A is associated with elevated circulatory MMP-2 levels and increased risk of cardiovascular disease in systemic lupus erythematosuspatients”, Lupus, 21(6), 616-624.
35. Medley, T. L., Kingwell, B.A., Gatzka, C.D., Pillay, P., Cole, T.J. (2013), “Matrix metalloproteinase-3 genotype contributes to age-related aortic stiffening through modulation of gene and protein expression”, Circ. Res, 92, 1254-1261.
36. Chen, W., Hua, K., Gu, H., Zhang, J., Wang, L. (2014), “Scand Methylenetetrahydrofolate reductase C667T polymorphism is associated with increased risk of coronary artery disease in a Chinese population”, J Immunol, 80(5), 346-353
37. Djuric, T., Zivkovic, M., Milosevic, B., Andjelevski, M., Cvetkovic, M., Kostic, M., Stankovic, A. (2014), “MMP-1 and -3 haplotype is associated with congenital anomalies of the kidney and urinary tract”, Pediatr Nephrol, 29(5), 879-884.
38. Zeng, R., Zhang, X., Wu, K., Su, Y., Wen, F. (2014), “MMP9 gene polymorphism is not associated with polypoidal choroidal vasculopathy and neovascular age-related macular degeneration in a Chinese Han population”, Ophthalmic Genet, 35(4), 235-240.
39. Singh, M., Singh, A.K., Pandey, P., Chandra, S., Singh, K.A., Gambhir, I.S. (2016), “Molecular genetics of essential hypertension”, Clin Exp Hypertens, 38(3), 268-277.
40. Tanner, R.M., Lynch, A.I., Brophy, V.H., Eckfeldt, J.H., Davis, B.R., Ford, C.E., Boerwinkle, E., Arnett, D.K. (2011), “Pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension”, PLoS One, 6(8), 23609.
41. Luizon, M.R., Belo, V.A., Fernandes, K.S., Andrade, V.L., Tanus-Santos, J.E., Sandrim, V.C. (2016), “Plasma matrix metalloproteinase-9 levels, MMP-9 gene haplotypes, and cardiovascular risk in obese subjects”, Mol Biol Rep, 43(6), 463-471.
42. Velho, F.M., Cohen, C.R., Santos, K.G., Silvello, D., Martinelli, N., Biolo, A., Clausell, N. (2011), “Polymorphisms of matrix metalloproteinases in systolic heart failure: role on disease susceptibility, phenotypic characteristics, and prognosis”, J Card Fail, 17(2), 115-121.
43. Hua, Y., Song, L., Wu, N., Xie, G., Lu, X., Fan, X., Meng, X., Gu, D., Yang, Y. (2009), “Polymorphisms of MMP-2 gene are associated with systolic heart failure prognosis”, Clin Chim Acta, 404(2), 119-123.
44. Richardson, P.D., Davies, M.J., Born, G.V.R. (2014), “Influence of plaque configuration and stress distribution on fissuring of coronary atherosclerotic plaques”, Heart, 99(10), 715-721.
45. Rodríguez-Pérez, J.M., Vargas-Alarcón, G., Posadas-Sánchez, R., Zagal-Jiménez, T.X., Ortíz-Alarcón, R., Valente-Acosta, B., Tovilla-Zárate, C., Nostroza-Hernández, C., Pérez-Méndez, O., Pérez-Hernández, N. (2016), “rs3918242 MMP9 gene polymorphism is associated with myocardial infarction in Mexican patients”, Genet Mol Res, 15(1).
46. Sakowicz, A., Hejduk, P., Pietrucha, T. (2015), “Association between ins4436A in 11β-hydroxysteroid dehydrogenase type 1 gene and essential hypertension in Polish population”, Postepy Hig Med Dosw (Online), 69,
1245-1250.
47. Seravalle, G., Mancia, G., Grassi, G. (2014), “Role of the sympathetic nervous system in hypertension and hypertension-related cardiovascular disease”, High Blood Press Cardiovasc Prev, 21(2), 89-105.
48. Morris, D.R., Biros, E., Cronin, O., Kuivaniemi, H., Golledge, J. (2014), “The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and meta-analysis”, Heart, 100(4), 295-302.
49. Pérez-Hernández, N., Vargas-Alarcón, G., Martínez-Rodríguez, N., Martínez-Ríos, M.A., Peña-Duque, M.A., Peña-Díaz Ade, L., Valente-Acosta, B., Posadas-Romero C., Medina A., Rodríguez-Pérez J.M. (2012), “The matrix metalloproteinase 2-1575 gene polymorphism is associated with the risk of developing myocardial infarction in Mexican patients”, J Atheroscler Thromb, 19(8), 718-727.
50. Xu, X., Wang, L., Xu, C., Zhang, P., Yong, F., Liu, H., Wang, J., Shi, Y. (2013), “Variations in matrix metalloproteinase-1, -3, and -9 genes and the risk of acute coronary syndrome and coronary artery disease in the Chinese Han population”, Coron Artery Dis, 24(4), 259-265.
51. Wang, J., Wang, Z., Yu, C. (2016), “Association of Polymorphisms in the Atrial Natriuretic Factor Gene with the Risk of Essential Hypertension: A Systematic Review and Meta-Analysis”, Int J Environ Res Public Health, 13(5).