Research Results in Biomedicine

Viet T. Pham, Thien H. Van, Loi T. Do, Ven T. Nguyen, Le P.T. Quoc, Hung Q. Nguyen, Tho T. Le, Diep Q. Dinh, Nga Nguyen-Phi

Background: Curcuma vitellina has been recently described as a new species in the flora of Vietnam. To date, it is a rare species and its phytochemical and ...

Optimization of Naltrexone and Nicotine Co-Delivery via PVP/PVA Microneedle Systems: A Translational Approach

Amisha S. Raikar, Shilpa P. Bhilegaonkar

Background: Addiction to alcohol and nicotine remains a global health challenge, with current treatment options often hindered by issues of frequent dosing and low patient adherence. Transdermal drug ...

Pre-treated Enterococcus faecalis with Sub-inhibitory concentrations of Cefepime Modulate Biofilm Formation and Adhesion in vitro

Hwazen A. Shnyoor, Ayaid K. Zgair

Background: Modifying biofilm formation and adhesion could aid in developing treatments for infectious diseases caused by Enterococcus faecalis, a multidrug-resistant bacteria responsible for urinary tract infections (UTIs). The ...

Therapeutic potential of Hsp70 in ALS and other proteinopathies: from molecular mechanisms to gene therapy (review)

Evgeny V. Bronovitsky, Kirill D. Chaprov, Sergei Y. Funikov, Mikhail B. Evgen'ev, Alexey A. Ustyugov

Background: Disruption of cellular proteostasis and aggregation of pathological proteins are central components in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Existing ...

Antiarrhythmic effect of amiodarone on epinephrine-induced ventricular arrhythmias in rats with experimental hyperglycemia and its combination with hypercholesterolemia

Evgeniy D. Kozlov, Angelina V. Zorkina

Background: Amiodarone, a class III antiarrhythmic agent, has been shown to be effective against epinephrine-induced ventricular arrhythmias in metabolically neutral animals. However, its effectiveness in models of ...

Mitigation of indomethacin-induced gastric inflammation in mice through the administration of ethanol extract from Hedyotis capitellata Wall. leaves

Tran T.P. Nhung, Le P.T. Quoc

Background: Gastritis, a prevalent global malady, stems from various factors such as unhealthy lifestyles, bacterial infections, or non-steroidal anti-inflammatory drug usage. If untreated, it leads to severe complications. ...

Neisseria gonorrhoeae LOS Decreased NF-ĸB and IRF3 Expression but Had No Effect in IFN-β Expression and HIV Replication on Naïve-HIV Lymphocytes

Niniek Budiarti, Loeki E. Fitri, Handono Kalim, Nuning Winaris, Aulia R. Pawestri, Dewi Santosaningsih, Aristika Dinaryanti, Siti Q. Khairunisa, Nasronudin .

Background: Neisseria gonorrhoeae (N. gonorrhoeae) is a gram-negative bacterium with a lipooligosaccharides (LOS)-based cell membrane. LOS is considered to supress HIV-1 replication by downregulating NF-κB, IRF3, and ...

Evaluation of efficacy of selective phenolic compounds of olive leaves in chronic myeloid leukemia: an in-silico approach

Riaz Hossain, Nishan Shorif, Sifat Foysal, Mohammad N. Islam

Background: Chronic myeloid leukemia (CML) is a blood cancer driven by the BCR-ABL1 fusion protein, where current therapies face challenges like resistance and side effects. Olive leaves ...

Experimental model of Alzheimer's disease caused by intrahippocampal injection of sodium azide. Comparability with the amyloid model

Dmitry I. Pozdnyakov

Background: The treatment of Alzheimer's disease is currently a complex medical task, requiring constant research and development of new medicines. This raises the question of choosing a relevant ...

An investigation into the acute and sub-chronic toxicityof ethanol extract of Ardisia sylvestris Pitard leaves in vivo

Tran T.P. Nhung, Le P.T. Quoc

Background: The global rise in the usage of herbal medicine has prompted a critical examination of its safety. Despite widespread assumptions of safety, there remains a need for ...

Development of Novel Antimicrobial Peptides Targeting Antibiotic-Resistant Pseudomonas aeruginosa

Ali H. Salama

Background: Antibiotic resistance is a global health threat, especially with pathogens like Pseudomonas aeruginosa, which displays high resistance to many antibiotics. Innovative solutions, such as antimicrobial peptides ...

Chemical composition and antimicrobial activities of Boesenbergia xiphostachya

Hop V. Nguyen, ShiPin Chen, An N.T. Huynh, Truc H.N. Tran, Ngoc L.H. Vo, Tho T. Le, Hung Q. Nguyen, Thien H. Van, An N. Nguyen, Hanh T.D. Nguyen, Viet T. Pham

Background: Boesenbergia xiphostachya is a rare species, recently discovered in Vietnam. Information about the chemical compositions and biological properties of distinct parts of this plant ...

Evaluation of the therapeutic effects of fonturacetam in the chronic unpredictable mild stress (CUMS) model in rats

Sona S. Arutyunyan, Elena V. Shekunova, Natalia M. Faustova, Vladimir A. Kashkin, Marina N. Makarova, Valery G. Makarov, Marat F. Fazylov, Vadim Yu. Balabanyan

Background: Chronic stress can lead to adverse consequences such as occupational burnout syndrome (OB). Considering the social significance of the disease and the lack of standard treatment, ...

Osteoprotective and regenerative effects of the plant polyphenol resveratrol in postmenopausal osteoporosis: an experimental pharmacological study

Olga A. Shevchenko, Aleksandr A. Dolzhikov, Mikhail V. Pokrovskii, Oleg S. Gudyrev, Irina N. Dolzhikova

Background: Osteoporosis is one of the major metabolic, age-related skeletal diseases and a serious medical and socioeconomic problem worldwide. This is due to its steadily increasing prevalence and ...

Exploring the Medicinal Potential of Jatropha gossypifolia Leaf Extract: a Comprehensive Analysis of Bioactive Compounds, Antimicrobial Activities, and Molecular Interactions in the Treatment of Atopic Dermatitis

Aparna Ramesh, Sasidharan S. Kumar, S Nikashini, R Krishnan, A Gokulkrishnan, Alish K. Victoriya, Venkatesa P. Sundramurthy

Background: Jatropha gossypifolia, a plant traditionally recognized for its therapeutic properties, has gained scientific interest due to its potential pharmacological applications. However, comprehensive studies exploring its bioactive constituents ...

Review of clinical trials of promising bispecific candidates for CAR-T cell therapy