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Pharmacology

Mechanisms of biological effectiveness of ionic forms of metals of variable valence in respiratory medicine
 

Volume 10, Issue №2, 2024
Background: The task to develop new drugs containing metals of variable valence requires systematization of our knowledge, experimental and clinical studies. The aim of the study: To investigate ...

Potential protective effect of alpha lipoic acid against testicular oxidative stress and altered gene expression induced by gentamicin treatment
 

Volume 10, Issue №2, 2024
Background: Gentamicin induces testicular damage in association with oxidative stress explained by different mechanisms, including gene expression suppression of some antioxidant enzymes. The aim of the study: ...

In vitro activity of the novel antimicrobial peptide WR-286 in combination with vancomycin against methicillin-resistant
Staphylococcus aureus
 

Volume 10, Issue №2, 2024
Background: Multidrug resistance bacteria are a serious problem for health specialists and all the people in the world. The main reasons for this problem are the misuse ...

Targeting the Bap1 protein of Vibrio cholerae for screening potent inhibitors and predicting the mutant protein stability: in silico analyses

Volume 10, Issue №1, 2024
Background: Bap1 is reported to be a major protein in Vibrio cholerae which aids in biofilm formation. Hence, inhibition of the protein molecule can no longer support the ...

Morphological changes in gum tissue during thiram intoxication followed by correction with resveratrol and sea buckthorn oil

Volume 10, Issue №1, 2024
Background: The widespread use of pesticides can lead to a violation of the ecological balance between the environment and the human body, provoking the development of oxidative ...

Curcumin Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Regulating Endoplasmic Reticulum Stress in The Liver

Volume 9, Issue №4, 2023
Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic pathological condition of the liver due to excess triglyceride accumulation in hepatocytes. The antioxidant properties of curcumin improve lipid ...

Seasonal periodontal microcirculation by combined stress in rats corrected with complex phytoadaptogen

Volume 9, Issue №4, 2023
Background: One of the negative inducers of the internal environment is inflammation; amongst external factors the most significant is polyetiological stress. One of the promising pharmacological methods of ...

Stress-protective activity of Astragalus physodes extract on the model of «social» stress

Volume 9, Issue №3, 2023
Background: In recent decades, in the conditions of human existence, special attention has been paid to the problem of stress and the body's response to the impact of stress ...

Effect of pyrimidine derivative on cytokine levels in experimental generalized staphylococcal infection

Volume 9, Issue №3, 2023
Background: To date, bacterial infections caused by microorganisms characterized by antibiotic resistance are one of the leading causes of the protracted course of infectious and inflammatory diseases that occur with ...

Effects of complex phytoadaptogens in matobolic syndrome

Volume 9, Issue №2, 2023
Background: The widespread prevalence of metabolic syndrome (MS) is becoming a serious problem for the population around the world, increasing the risk of developing type 2 diabetes and complications ...

Correction of mitochondrial dysfunction with cinnamic acids in experimental hypercytokinemia

Volume 8, Issue №3, 2022
Background: Mitochondrial dysfunction is an essential component of the hypercytokine neurotoxicity pathogenesis and is a promising pharmacotherapeutic target. The aim of the study: To evaluate the effect of cinnamic acids ...
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