Medicine (miscellaneous)
Genetic predictors of efficacy and safety of clozapine therapy (review)
Volume 12, Issue №3, 2026
Background: Clozapine remains an indispensable antipsychotic for patients with treatment-resistant schizophrenia, but its use can induce adverse drug reactions. Genetic characteristics of patients explain interindividual variability in ...
Personalized telerehabilitation in the context of modern determinant of gerontological care (review)
Volume 12, Issue №3, 2026
Background: Stroke is one of the leading causes of disability in the elderly. Modern healthcare systems face workforce shortages and limited access to inpatient rehabilitation, especially in remote ...
The influence of maternal deprivation on the level of extracellular dopamine when modeling the state of excitement
Volume 12, Issue №2, 2026
Background: Maternal deprivation (MD) in early ontogenesis causes persistent changes in emotional reactions and drug abuse in animals. In the present study, we modeled an addictive state of ...
The prospects of regulating the interaction between NK cells and trophoblast cells through cyclin-dependent kinase inhibitors
Volume 12, Issue №2, 2026
Background: Background: Analyzing the interaction between natural killer (NK) cells and trophoblast cells is crucial for understanding reproductive immunology processes and developing innovative therapeutic approaches. This study ...
The relationship between fibroblast growth factor 21 (FGF-21) and clinical and laboratory parameters in geriatric patients with rheumatoid arthritis
Volume 12, Issue №2, 2026
Background: Systemic FGF-21 levels are known to be associated with obesity and inflammatory cytokines, and with reduced functional status in rheumatoid arthritis (RA). It is possible to ...
Age-related diagnostic and deficiency features patients with metabolic-associated fatty liver disease
Volume 12, Issue №1, 2026
Background: Due to the growing elderly population and persistent nutritional misconceptions, the prevalence of metabolic-associated fatty liver disease (MAFLD) is rising. This condition can further worsen the ...
Validation of the Russian version of the Recovery Assessment Scale – Domains and Stages (RAS-DS) to assess recovery after the first psychotic episode
Volume 12, Issue №1, 2026
Background: This scientific article is significant due to the lack of Russian-language psychometric scales that can objectively assess the parameters of personal recovery within the broader concept of ...
Artificial intelligence models in cardiotocography (review)
Volume 12, Issue №1, 2026
Background: Fetal hypoxia is a pathological state characterized by insufficient oxygen supply to the human fetal tissue. Oxygen deficiency causes a cascade of pathological complications, including decompensation, ...
Age-related resilience in critical periods of life of patients with visual deficits and injuries
Volume 11, Issue №4, 2025
Background: Visual impairment and injuries in patients are common in older groups and their prevalence will increase as they age. At the same time, visual deficits and ...
Effect of cytokine gene polymorphisms on the risk of preeclampsia
Volume 11, Issue №4, 2025
Background: Preeclampsia is a multisystem disorder based on placental and endothelial dysfunction, leading to hypertension and other damage to organs and systems during pregnancy and is the leading ...
The role of mental disorders in the pathogenesis of atopic dermatitis (review)
Volume 11, Issue №4, 2025
Background: The problem of atopic dermatitis has received significant attention from researchers across different fields over the years. Despite its high prevalence, there remains an incomplete understanding ...
Effect of sarcopenic obesity and visual deficits on the physical functionality of elderly patients
Volume 11, Issue №3, 2025
Background: Sarcopenic obesity and visual deficits represent widespread functional deficits, but despite this, their significance in changing the physical functionality of elderly patients with sarcopenic obesity and ...
Features of the gut microbiome in people with increased anxiety
Volume 11, Issue №3, 2025
Background: Anxiety and anxiety disorders are among the most common mental illnesses worldwide. There is increasing evidence that the gut microbiome plays a role in the development ...
The influence of eating patterns and dietary habits, deficiency of macro- and micronutrients on the reproductive health of women (review)
Volume 11, Issue №3, 2025
Background: Russian and international literature increasingly focuses on identifying modifiable environmental, lifestyle, and nutritional risk factors that affect human reproductive function. Furthermore, it is crucial to recognise ...
Effect of visual impairment and arterial hypertension on the prevalence of geriatric syndromes in elderly patients
Volume 11, Issue №2, 2025
Background: Arterial hypertension and visual impairment due to various ophthalmopathologies are common age-related diseases, but their combined effect on the geriatric profile of patients has not been practically ...
Effect of Cigarette Smoke on Female Reproductive System: A Sytematic Review
Volume 11, Issue №2, 2025
Background: The closest toxic exposure is cigarette smoke, and nowadays smokers are not only men but also women. Although the number of smokers has dropped, cigarettes remain ...
Suicidal behavior and comorbid somatic diseases (review)
Volume 11, Issue №2, 2025
Background: Suicidal behavior continues to be one of the most acute medical problems, the relevance of which continues to remain at a high level. The article presents an ...
The etiology and pathogenesis of atherosclerosis: modern insights and age-dependent aspects (review)
Volume 11, Issue №2, 2025
Background: Atherosclerosis is a leading cause of morbidity and mortality worldwide. It is a systemic pathological process attributed to the deposition of atherogenic lipoproteins in the intima of ...
Regulation of natural killer cells cytotoxicity by trophoblast cells: proteins and receptors
Volume 11, Issue №1, 2025
Background: Interaction between trophoblast and natural killer cells is determined by microenvironment. Cytotoxicity of NK against targets, including trophoblasts, is associated with production of perforin, granzymes. Trophoblasts are ...
Features of testing the basic functional activity of patients with sarcopenic obesity and visual impairment
Volume 11, Issue №1, 2025
Background: Various functional deficits, including visual deficits, as well as sarcopenic obesity, cause a decrease in activity in the daily life of patients. These deficits are challenging ...
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