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Genetics

Sex-specific features of interlocus interactions determining susceptibility to hypertension
 

Volume 10, Issue №1, 2024
Background: Hypertension (HT) belongs to a group of widespread diseases in both men and women, but at the same time the disease is more often registered (≈20%) ...

Retroelements in targeted antitumor therapy (review)

Volume 10, Issue №1, 2024
Background: Pathological expression of retroelements is determined in most malignant tumors, which reflects the pathogenesis of tumors, since activated retrotransposons cause genomic instability due to a cascade ...

Features of associations of SHBG-related genes with breast cancer in women, depending on the presence of hereditary burden and mutations in the BRCA1/CHEK2 genes

Volume 10, Issue №1, 2024
Background: One of the most common diseases of the female population is breast cancer (BC), which is a hormone-dependent pathology and has a significant hereditary component. Candidate ...

Mendelian randomization in eye disorders (review)

Volume 10, Issue №1, 2024
Background: Mendelian randomization (MR) is an analytic approach in genetic epidemiology which uses the results of genome-wide association studies (GWAS) to assess causal relationships between various risk ...

Clinical and genetic characteristics of cystic fibrosis in the Republic of Bashkortostan

Volume 9, Issue №4, 2023
Background: According to estimates of the World Health Organization, 40-50 thousand children worldwide are born each year with cystic fibrosis (CF), a monogenic disease with genetic heterogeneity and ...

NOS3 gene polymorphism variants and main characteristics of heart rate variability in Northerners

Volume 9, Issue №4, 2023
Background: Heart rate variability as a demonstration of autonomic nervous system function reflects human health and well-being. By monitoring heart rate variability indices and focusing on the imbalance ...

Prospects for the investigation of retroelements for COVID-19 therapy (review)

Volume 9, Issue №4, 2023
Background: The search for methods to detect COVID-19 using genetic advances can become the basis for an effective fight against this viral infection. Targeted therapy using non-coding RNAs ...

Associations of polymorphic variants of candidate genes with the development of H. pylori-negative duodenal ulcer in residents of the Central Chernozem region of Russia

Volume 9, Issue №3, 2023
Background: Peptic ulcer disease (PUD) is a chronic recurrent disease that occurs with alternating periods of exacerbation and remission, the leading manifestation of which is the formation of a ...

The role of DNA methylation in lung cancer (review)

Volume 9, Issue №3, 2023
Background: Lung cancer has been a difficult-to-treat disease for decades, despite the efforts of oncologists and pharmaceutical companies. One of the reasons for this is the heterogeneity of the ...

Genetic markers of knee osteoarthritis in women of the Central Chernozem region of Russia

Volume 9, Issue №2, 2023
Background: Knee osteoarthritis (KO) is a multifactorial disease. Among the many risk factors for the disease, the role of the hereditary component is undeniable. The share of genetic factors ...

A replication study of genetic variants associated with high-level musical aptitude

Volume 9, Issue №2, 2023
Background: Existing genetic studies on musical abilities have focused on various molecular approaches, which determined gene regions/variants implicated in (i) music perception and performance based on genome-wide linkage ...

Association between mitochondrial DNA copy number and high viral load in women with high-risk human papillomavirus

Volume 9, Issue №2, 2023
Background: The infection that most often leads to cervical cancer is human papillomavirus (HPV) infection. A sign that the HPV infection might develop into cancer is mitochondrial dysfunction and ...

Mendelian randomization: using genetic information in epidemiological studies (review)

Volume 9, Issue №2, 2023
Background: Mendelian randomization is a research method that exploits the instrumental variable framework using genetic information to assess the causality of the relationship between modifiable risk factors and health ...

Polymorphic loci of AC026703.1 and HFE genes are associated with severe hypertension
 

Volume 9, Issue №1, 2023
Background: Hypertension (HT) is characterized by high blood pressure (BP) and is one of the most common diseases in the world. At the moment, there is information in the ...
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