MOLECULAR AND GENETIC CHARACTERISTICS OF PATIENTS WITH HYPERPLASIA AND ENDOMETRIC POLYPS
Background. Hyperplastic processes of the endometrium (GGE) are among the most frequent gynecological diseases, leading to a loss of reproductive function and a decrease in the quality of life of women, and are the basis for the formation of malignant endometrial tumors. The aim of the study. To study the involvement of cytokine candidate genes in the formation of endometrial hyperplasia and polyps. Materials and methods. The sample for the study was 243 women with hyperplastic endometrial processes and 249 women in the control group. Samples of patients and control included women of Russian nationality. All patients with GGE and women of the control group were subjected to genotyping of nine molecular-genetic markers by the polymerase chain reaction of DNA synthesis: -308 G/A TNFα, +252 A/G Ltα, +36 A/G TNFR1, + 1663G/A TNFR2, 403A/G RANTES, A/G I-TAC (rs4512021), + 1931A/T MIP1β, C/G MCP1 (rs2857657), -801G/A SDF1. Results. It was found that with the development of endometrial hyperplasia, fourteen combinations of polymorphic markers -308 G/A TNFα, +252 A/G Ltα, +36 A/G TNFR1, +1663A/G TNFR2, +1931 A/T MIP1β, C/G MCP1 (rs2857657), -801 G/A SDF1. These combinations increase the risk of developing endometrial hyperplasia (OR = 2.05-4.11). The formation of endometrial polyps is associated with three combinations of genetic variants: +252 AA Ltα and +36 AG TNFR1 (OR = 2.22); +252 AA Ltα and + 36 A TNFR1 (OR = 1.71); +36 A TNFR1 and -801 GG SDF1 (OR = 1.70). Conclusion. Combinations of polymorphic loci 308 G/A TNFα, +252 A/G Ltα, +36 A/G TNFR1, +1663A/G TNFR2, +1931 A/T MIP1β, C/G MCP1 (rs2857657), -801 G/A SDF1 are associated with the development of endometrial hyperplasia, and the combinations of the polymorphisms +252 A/G Ltα, +36 A/G TNFR1, -801 G/A SDF1 are associated with the development of endometrial polyps.
Demakova NA. Molecular and genetic characteristics of patients with hyperplasia and endometric polyps. Research Result. Medicine and Pharmacy. 2018;4(2):26-39 (In Russian) . DOI: 10.18413/2313-8955-2018-4-2-0-4
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