DOI: 10.18413/2313-8955-2018-4-3-0-1

EXPRESSION OF TOLL-LIKE RECEPTORS IN THE FEMALE REPRODUCTIVE TRACT AND ITS HORMONE REGULATION (REVIEW)

Background: Toll-like receptors (TLR) are the main receptors of the innate immune system, recognizing ligands of bacteria, viruses, fungi and protozoa and inducing immune response. However, complex reviews of new data about expression and function of TLR in all organs of the female reproductive tract (including fallopian tubes and ovaries) and its hormone regulation have not been carried out. The aim of the study: To perform an up-to-date review of the literature concerning expression of TLR in the vagina, ecto- and endocervix, uterus, fallopian tubes and ovaries and its hormone regulation. Materials and methods: The analysis of publications over the past 20 years in databases Pubmed, Google Academy, Scopus, Elibrary, ResearchGate, EBSCO has been carried out. Results: The review presents new data on the expression of TLR in the vagina, ecto- and endocervix, uterus, fallopian tubes and ovaries. The role of TLR is described not only in inducing an immune response and providing protection against infections, but also in regulating the capitation of spermatozoa and in fertilization.The effect of sex hormones (estradiol, progesterone) on expression and TLR function is estimated. Conclusion: TLR expression was found inall organs of the female reproductive tract. Expression of TLR is under the influence of sex hormones and is the maximum in the secretory phase of the menstrual cycle. TLR take part not only in defense of the reproductive tract against infections, but also in reproduction (capacitation of spermatozoa, fertilization, protection of gametes and embryos).

Keywords: toll-like receptors, TLR, innate immunity, infections, capacitation, fertilization, estradiol, progesterone.

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Lebedeva OP, Qirko R. Expression of toll-like receptors in the female reproductive tract and its hormone regulation (review). Research Results in Biomedicine. 2018;4(3):3-17 (In Russian).
DOI: 10.18413/2313-8955-2018-4-3-0-1

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