Association of lipid and carbohydrate metabolism disorders with blood pressure indicators in the morning and evening hours in patients with elderly metabolic syndrome
Background: Metabolic syndrome associated with hypertension, lipid and carbohydrate metabolism disorders in the elderly and senile is common, which indicates the relevance of its study, including the study of blood pressure parameters in the morning and evening hours. The aim of the study: Analysis of hemodynamic parameters and characteristics of lipid, carbohydrate metabolism in elderly patients with metabolic syndrome and arterial hypertension. Materials and methods: The above disorders were analyzed in 156 patients with metabolic syndrome. To determine the blood pressure there was used the device AVRM-04 of the Meditech company. Carbohydrate and lipid metabolism were assessed by conventional methods. Results: In elderly patients with metabolic syndrome and hypertension, compared with middle-aged patients, significant differences were found in the maximum value of systolic and diastolic blood pressure, and the maximum morning hours index. In the evening hours, pronounced differences in the compared groups were for the values of systolic and diastolic blood pressure. Significant dyslipidemia and hyperglycemia were established in elderly patients with metabolic syndrome in comparison with the control. On the basis of the correlation method in the main and control groups, reliable direct connections were revealed (r= + 0,365 and r=+0,318, P<0,05) between the content of triglycerides and glucose in the blood serum, between the level of low-density lipoproteins and glucose (r=+0,412 and r=+0,348, P<0,05). In elderly patients with metabolic syndrome, direct moderate associations were established between triglyceride content, atherogenicity coefficient and systolic blood pressure in the morning and evening. Conclusion: Significant differences in blood pressure parameters were established in the studied patients of middle and old age. Significant dyslipidemia and hyperglycemia were revealed in elderly patients with metabolic syndrome in comparison with the control. The noted patterns must be used to diagnose and improve drug treatment of the metabolic syndrome in the elderly.
Markelova EA, Lutay YuA. Association of lipid and carbohydrate metabolism disorders with blood pressure indicators in the morning and evening hours in patients with elderly metabolic syndrome. Research Results in Biomedicine. 2020;6(1):126-134. (In Russian) DOI: 10.18413/2658-6533-2020-6-1-0-11
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