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DOI: DOI: 10.18413/2658-6533-2023-9-2-0-5

Effects of complex phytoadaptogens in matobolic syndrome

Background: The widespread prevalence of metabolic syndrome (MS) is becoming a serious problem for the population around the world, increasing the risk of developing type 2 diabetes and complications from the cardiovascular system. The aim of the study: To evaluate experimentally the changes caused by the metabolic syndrome in the microcirculation, the structure of the kidneys, the biochemical parameters of blood serum, the stress resistance of rats and the possibility of their correction with complex phytoadaptogens (CPhA). Materials and methods: The experiment was performed on 40 male Wistar rats (9-10 weeks old, body mass 330 ±20 g), divided into 3 groups: 1 – control, 2 – metabolic syndrome (MS), 3 – correction of metabolic syndrome with complex phytoadaptogenes (CPhA). The animals from group 2 and group 3 were receiving a high – carbohydrates, high – fat diet for 16 weeks. Blood serum for biochemical analysis was collected through a heart puncture. Microcirculation parameters were analyzed by Doppler ultrasound. The complex phytoadaptogens is composed from official 70% tincture of Glycyrrhiza glabra and 40% tincture of Rhodiola rosea, Acantopanax senticosus in the ratio 2:1:1. Group 3 was administered CPhA for 14 days with drinking water after 16 weeks of diet. Anxiety and motor activity of rats were analyzed using the “open field” test and calculated using Realtimer software (OpenScience, Russia). Kidney tissue samples were stained with hematoxylin-eosin (H&E) and study was carried out using a polarizing microscope with a digital camera ZEISS Axio Lab.A1 (Germany). The data were analyzed using the Statistica 10.0 software (StatSoft, Inc., Russia). Results: Based on the results of the experiment, we can conclude that the parameters of microcirculation (systolic (Vas) (P=0.047), diastolic (Vakd) (P=0.046) blood flow velocity significantly increase), biochemical parameters (total cholesterol by 32 8% (p=0.017), triacylglycerides by 57.36% (p=0.017), LDL by 64.13% (p=0.017) relative to MS significantly decrease) of blood plasma are directly affected by complex phytoadaptogens in the correction of the metabolic syndrome. Conclusion: The use of complex phytoadaptogens can become a promising addition in the treatment of metabolic syndrome and its components (abdominal obesity, insulin resistance, dyslipidemia, systemic endothelial dysfunction) by influencing the central pathophysiological links and a number of etiological factors of MS.

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