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DOI: 10.18413/2658-6533-2023-9-3-0-5

Stress-protective activity of Astragalus physodes extract on the model of «social» stress

Background: In recent decades, in the conditions of human existence, special attention has been paid to the problem of stress and the body's response to the impact of stress factors of various nature (somatic, cognitive, emotional, etc.). It has been proven that the influence of various types of stress leads to disruption of the psycho-emotional state and regulation of various systems and, as a result, the gradual depletion of the body's adaptive capabilities and the development of stress-associated diseases. Herbal preparations are among the effective correctors of stress-induced disorders. Phytopreparations based on plants of the Astragalus genus attract research attention. It has been proven that various representatives of this genus contain active substances with a wide range of biological activity. The aim of the study: To evaluate the effect of Astragalus physodes herb extract on the behavioral responses of laboratory animals using the Porsolt and Lattice tests as an example. Materials and methods: The study was carried out on outbred male rats aged 6-8 months. The animals were divided into groups (n=10): 1 – the control group was formed by intact rats, which were one individual per cage; 2 – animals exposed to social» stress (victims/aggressors); 3 – individuals exposed to «social» stress and receiving intragastrically an extract of Astragalus physodes at a dose of 50 mg/kg/day for 14 days (victims/aggressors), starting from the 21st day of the experiment. «Social» stress was modeled by the formation of aggressive (aggressors) and submissive (victims) types of behavior in conditions of paired sensory contact. Animal behavior was assessed using the Porsolt and Lattice psychopharmacological tests. Results: It has been established that «social» stress contributes to the development of an anxiety-depressive state, which requires correction by medicines with stress-protective activity. The neuro- and stress-protective activity of plants of the genus Astragalus was established, which is probably ensured by the presence of saponins and flavonoids, which have a corrective effect on neurotransmitter systems. Conclusion: The obtained results confirm the presence of psychomodulatory activity of Astragalus physodes extract under stressogenic conditions, which was manifested by an increase in horizontal and vertical motor activity, as well as a decrease in the anxiety-depressive parameters in the behavior of laboratory animals.

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