Association of polymorphic locus rs4880 of superoxide dismutase 2 gene (SOD2) with Polycystic Ovary Syndrome: A meta-analysis
Background: According to WHO, approximately 8-13% of women of reproductive age suffer from polycystic ovary syndrome (PCOS), while up to 70% of women worldwide with PCOS remain undiagnosed. PCOS is the most common cause of anovulation and the main cause of infertility. PCOS is characterized by oxidative stress and a decrease in antioxidant status. The activity of antioxidant enzymes is genetically determined and depends on the presence of polymorphic alleles, and it has been shown that the polymorphic variant Ala16Val of the SOD2 gene can lead to enzyme depletion and be associated with the risk of PCOS. There are contradictory data in the literature on the association of the polymorphic locus rs4880 of the SOD2 gene with PCOS. The aim of the study:To investigate the association of the polymorphic locus Val16Ala of the mitochondrial superoxide dismutase (SOD2) gene with polycystic ovarian syndrome according to the PRISMA protocol of systematic reviews and meta-analyses in case-control studies. Materials and methods: A comprehensive search was conducted on electronic databases, including PubMed, eLibrary, Science Direct, Google Scholar, EMBASE, Scopus and the Cochrane Library of studies published before December 2022 and devoted to the search for associations between rs4880 polymorphism in the SOD2 gene and PCOS. The search was conducted by the following keywords: "Polycystic ovary syndrome" or "PCOS", "superoxide dismutase 2" or "SOD2" or "MnSOD", "polymorphism" or "SNP" or "variant" or "rs4880" or Ala16Val or C47T in English, Arabic and Russian. Out of 95 relevant publications, 6 suitable case-control studies with 1,606 cases of PCOS and 1,333 controls met the criteria for inclusion in this meta-analysis. Most of the selected studies were conducted in Western Asia. The meta-analysis was carried out in accordance with the PRISMA protocol and using Review Manager version 5.4. Results: It has been shown that the presence of at least one copy of the T-allele in the polymorphic locus rs4880 in patients with PCOS was shown to increase the risk of developing the syndrome in three genetic models: dominant, allelic and heterozygous. Conclusion: The results of the meta-analysis demonstrate that the rs4880 polymorphism of the SOD2 gene may be a risk factor for the development of PCOS, and it is assumed that the Val allele may increase the risk of developing PCOS
Ali RM, Lomteva SV, Alexandrova AA, et al. Association of polymorphic locus rs4880 of superoxide dismutase 2 gene (SOD2) with Polycystic Ovary Syndrome: A meta-analysis. Research Results in Biomedicine. 2025;11(1):57-74. Russian. DOI:10.18413/2658-6533-2025-11-1-0-3
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