DOI: 10.18413/2658-6533-2025-11-3-0-1

**Associations of the 786T>C (rs2070744) polymorphism of the NOS3 gene with main somatometric indices and cardiovascular system characteristics in the age aspect in northern men**

Background: A lack of information regarding the association between NOS3 gene polymorphism variants and age-related changes in basic somatometric characteristics and the circulatory system prevents us from forming a comprehensive understanding of age-related changes in fundamental cardiovascular indicators among northerners. The aim of the study:The objective of this study was to conduct an analysis of the age-related dynamics of somatometric parameters and indicators of the cardiovascular system among men living in the northern regions, as well as to uncover associations between these indicators and different variants of the 786T>C (rs2070744) polymorphism of the NOS3 gene. Materials and methods: Totally 245 people made up the study sample which was divided into three age groups depending on ontogeny: adolescent (n=109), mature (n=97) and elderly (n=39). In each age group, subgroup 1 (TC+CC genotypes) and subgroup 2 (homozygotes with TT genotype) were identified and compared based on somatometric characteristics and cardiovascular system indicators. Results: Progressive changes in body mass, BMI and total body fat content have been revealed in the ontogenetic line from young men to elderly men. Systolic and diastolic blood pressure as well as total peripheral vascular resistance tended to increase with age with a fall in the cardiovascular system volume characteristics – stroke volume and cardiac output. The NOS3 *C allele in the genotype showed the link to less pronounced changes in body mass, BMI and total body fat content. At the same time, the presence of this allele in the genotype can be considered as an additional risk factor for age-associated disorders in cardiovascular performance. Only the elderly men of Group 2 (TC+CC genotypes) experienced systolic isolated hypertension with vasoconstriction signs. Decreased in the age aspect stroke (systolic) volume was caused by the combined effect of the age and genotype factors. Conclusion: The results obtained indicate associations of the 786T>C (rs2070744) polymorphism of the NOS3 gene with such cardiovascular indices as systolic and diastolic blood pressure and total peripheral vascular resistance

Keywords: young adults, mature men, elderly men, anthropometric indices, cardiovascular system, 786T>C (rs2070744) polymorphism of the NOS3 gene.

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Bezmenova IN, Averyanova IV. Associations of the 786T>C (rs2070744) polymorphism of the NOS3 gene with main somatometric indices and cardiovascular system characteristics in the age aspect in northern men. Research Results in Biomedicine. 2025;11(3):400-415. Russian.
DOI: 10.18413/2658-6533-2025-11-3-0-1

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