CLINICAL EFFICIENCY OF AZILEKT IN THE THERAPY OF PRIMARY PROGRESSING MULTIPLE SCLEROSIS
Multiple sclerosis − the chronic multifactorial progressing autoimmune disease of the central nervous system developing at any age, but mainly in young people. One of the factors of progression, along with the demyelination process is axonal degeneration and imminent death of the cell body. Currently, scientists are actively searching for new drugs for the treatment of MS, the drugs that can inhibit proapoptotic factors and activate the anti-apoptotic molecules. In the capacity of a drug with similar effects on patients, we used the drug Azilekt (TEVA) which affects the process of preventing the nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase, the activation of anti-apoptotic molecules, the suppression of proapoptotic factors and conservation capacity of mitochondria. We have revealed that the use of the drug Azilekt as a cytoprotective therapy in patients suffering from secondary progressive multiple sclerosis is likely to improve the effectiveness of treatment and quality of life of patients.
Gubarev YuD, Chefranova ZhYu, Yatsenko EA. Clinical efficiency of azilekt in the therapy of primary progressing multiple sclerosis. Research Result. Medicine and Pharmacy Series. 2015;1(4):5-12 (In Russian). DOI: 10.18413 / 2313-8955-2015-1-4-5-12
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