DEVELOPMENT AND VALIDATION OF METHODS OF QUANTITATIVE DETERMINATION OF IMATINIB IN THE BLOOD PLASMA BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION
The authors have developed a method of quantitative determination of an antitumor agent − a protein kinase inhibitor in the blood plasma by high performance liquid chromatography with tandem mass spectrometric detection. The analytical method range was from 0.03 to 3.83 g / ml in plasma. The method was used for the bioequivalence study of the reconstituted medicine containing imatinib as an active pharmaceutical ingredient compared with the reference.
Avtina TV, Kulikov AL, Pokrovsky MV. Development and validation of methods of quantitative determination of imatinib in the blood plasma by high performance liquid chromatography with mass spectrometric detection. Research Result. Medicine and Pharmacy Series. 2015;1(3):104-111 (In Russian). DOI:10.18413/2313-8955-2015-104-111
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