The article covers the results of the research into the influence of the combination of cinnamic acid derivative and polyphenolic structure compound on physical performance and psycho-emotional state of experimental animals in the conditions of daily exhaustive loads. The experiment used outbred male mice weighing 20-22 grams, divided into three equal experimental groups. The investigated combination of compounds included: catechin hydrate (Sigma - Aldrich) - compound polyphenol structure and ATACL - cinnamic acid derivative introduced per os in two dosing variants: 200 mg / kg catechol hydrate + 100 mg / kg ATACL and 100 mg / kg catechol hydrate + 50 mg / kg ATACL. The control group received 0.9% sodium chloride solution in equivolume amounts. The performance was assessed on the model of forced swimming load with 20% of the weight of the animal. The changes in animal models of mental and emotional status were evaluated in the "open field" test. The experiment lasted 15 days. The study found that in the control group, by the end of the experiment there was a decrease of 42% efficiency, with respect to the initial value of this group of mice and the development of psycho-neurological deficits, followed by a decrease in locomotor (1.5 times), tentatively-research activity (2.4 times) and an increase in the level of anxiety (70.8%). The use of the studied combination in both metering embodiments helped to maintain efficiency (compared to the control group, there was 114.7% increase of endurance with the application of 200 mg / kg + catechin hydrate 100 mg / kg ATACL and 130% increase when administered 100 mg / kg + catechin hydrate 50 mg / kg ATACL), and correction occurring against a background of exhaustive loads of psycho-emotional disorders. At the same time the leader in the studied species is the combination of pharmacological activity №2, t. E. 100 mg / kg of catechin hydrate + 50 mg / kg ATACL.