Research Results in Biomedicine
Volume 6, Issue №3, 2020
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Genetics
2q14 de novo interstitial deletion in a girl with intellectual disabilities and malformations
Background: Neurodevelopmental disorders have a prevalence of approximately 3% in the population, the genetic factor is involved in this condition. Microdeletions that comprise the 2q14.1q14.3 region are rare ...
Aplastic anemia, clinical implications and DNA damage in workers with occupational exposure to aromatic hydrocarbons in Rio de Janeiro
Background: Brazilian gas station workers (GWS) are daily exposed to petroleum-derived hydrocarbons which are harmful. The aim of the study: The aim of this study was to evaluate the clinical ...
Association of L432V (rs1056836) polymorphism of the CYP1B1 gene with the increased risk of colorectal cancer in the population of Central Russia
Background: Colon malignancies are one of the most common worldwide. Different pro-carcinogenic agents such as polycyclic aromatic hydrocarbons (PAH) and heterocyclic aromatic amines can potentially play a key role ...
Modern genomics in studying the problems of human adaptation to climate in north Siberia
Background: Indigenous people of north Siberia live in some of the harshest natural conditions on Earth, experiencing prolonged exposure to cold, large fluctuations in the length of daylight, ...
Study of associations of candidate genes differentially expressed in the placenta with the development of placental insufficiency with fetal growth restriction
Background: Placental insufficiency (PI) is a key feature of pregnancies with fetal growth restriction (FGR). FGR is defined as pathological inhibition of intrauterine growth of the fetus and ...
Polymorphism of the VEGFA gene, smoking and coronary heart disease: the significance of gene-environmental interactions for disease susceptibility
Background: Coronary heart disease (CHD) is a common disease with a high mortality rate in Russia, so the problem of early prognosis and prevention of this disease is ...
Pharmacology
The final results of the ASSA-II study: the knowledge of therapeutic doctors on the subject of bronchial asthma
Background: Bronchial asthma (BA) is one of the leading and socially significant diseases of the respiratory system. In recent years, the proportion of this disease has been steadily ...
Investigation of cerebroprotective properties of the drug «Mexidol» on the model of pneumococcal bacterial meningitis in experimental conditions
Background: Pneumococcal meningitis is a severe infectious disease, which is characterized by high mortality and frequent development of residual neurological damage. Effective cerebroprotection can improve the outcome of ...
Medicine (miscellaneous)
The proresilients in multimodal programmes for the prevention of premature ageing
Background: Premature ageing is a common process. According to various authors, at least 10-20% of middle-aged people have unfavorable levels of discrepancy between biological and passport age. That ...
Features of myocardial infarction with ST segment elevation in patients of the older age group
Background: Despite the fact that the incidence of myocardial infarction remains extremely high, and the average age of patients (given the increase in average life expectancy) is in the ...
Clinical and psychological analysis of emotional and personality disorders in patients with long-term consequences of craniocerebral trauma complicated and uncomplicated by alcoholism
Background: The importance and relevance of studies of neuropsychiatric disorders in the remote period of craniocerebral trauma (CCT) is determined by high incidence of both head injuries (1-4 per ...
Premature birth, modern realities
Background: Preterm birth is the main cause of neonatal and infant mortality, child morbidity and disability. The rate of premature birth, despite our knowledge of risk factors, pathogenetic mechanisms ...
