The role of interaction of polymorphic loci of the FLG gene in the development of chronic true eczema in women
Background: Eczema is a multifactorial disease. Its development is determined by the polygenic basis and the action of inciting events of exogenous and endogenous nature. The aim of the study: To analyze the role of interaction of polymorphic loci of the filaggrin gene (FLG) in the development of chronic true eczema in women. Materials and methods: A sample of 446 women was formed for the study, including 233 patients with chronic true eczema and 213 women without the disease. All women involved in the study underwent the necessary clinical and clinical laboratory examination. Nine polymorphic loci of the filaggrin gene were genotyped. The SNP×SNP interactions involved in the formation of chronic true eczema were studied using the АРSampler software (using the Monte Carlo Markov chain method and Bayesian nonparametric statistics) and MDR (based on the MDR dimension reduction method). Results: The two-and three-locus models associated with disease formation include five polymorphic loci-rs61816761, rs4363385, rs77199844, rs471144, and rs558269137 of the FLG gene. Polymorphisms rs4363385 and rs77199844 are included in the largest number of models (6 models respectively). SNP×SNP interactions rs471144× rs77199844 and rs471144× rs4363385 determine -0.84% and -0.77% of trait entropy respectively. Polymorphic loci rs77199844 and rs471144 are localized in the region of DNA regulatory motives to 12 transcription factors, and polymorphism rs4363385 of the FLG gene is associated with the expression level of nine genes in the skin (SPRR1B, LCE3C, LCE1D, SPRR2D, SPRR2B, LCE3A, LCE1E, SPRR1A, SPRR3). Conclusion: Interactions of polymorphic loci of the FLG gene are associated with the development of chronic true eczema in women.
Belyaeva TM. The role of interaction of polymorphic loci of the FLG gene in the development of chronic true eczema in women. Research Results in Biomedicine. 2019;5(4):5-18. (In Russian)
DOI: 10.18413/2658-6533-2019-5-4-0-1
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