Pharmacology
Correction of mitochondrial dysfunction with cinnamic acids in experimental hypercytokinemia
Volume 8, Issue №3, 2022
Background: Mitochondrial dysfunction is an essential component of the hypercytokine neurotoxicity pathogenesis and is a promising pharmacotherapeutic target. The aim of the study: To evaluate the effect of ...
In silico identification of the potential natural inhibitors of SARS-CoV-2 Guanine-N7 methyltransferase
Volume 8, Issue №3, 2022
Background: The outbreak of the COVID-19 pandemic caused by the SARS-CoV-2 has triggered intense scientific research into the possible therapeutic strategies that can combat the ravaging disease. One ...
Studies to elucidate the effect and antiapoptotic mechanism of 2-ethyl-3-hydroxy-6-methylpyridine-n-acetyltaurinate in a rat model of retinal ischemia–reperfusion
Volume 8, Issue №3, 2022
Background: The study of possible ways of effective correction of retinal ischemia-reperfusion injury, which accompanies a number of eye diseases, is relevant today. The aim of the ...
Pharmacological characteristics of intranasal dosage forms containing Ginkgo biloba extracts
Volume 8, Issue №2, 2022
Background: This article reviews the pharmacological characteristics of developed dosage forms for intranasal administration. The influence of the type of dosage form on the efficacy of the ...
Status of the glutathione antioxidant defense in fungicide intoxication and correction with vitamin A and milk thistle
Volume 8, Issue №2, 2022
Background: Thiram entering with food products into tissues and organs of animals and humans can lead to the activation of free-radical oxidation processes and, as a consequence, ...
Wound healing effect of organometallic zinc complex in the rat model of planar skin wound
Volume 8, Issue №1, 2022
Background: The complex and dynamic process of wound healing involves the stages of inflammation, proliferation and maturation of the connective tissue of the scar. Zinc, as an essential ...
Effect of sodium-glucose cotransporter type 2 inhibitors on the dynamics of functional and structural disorders in the simulation of post-contrast acute kidney injury
Volume 8, Issue №1, 2022
Background: Sodium-glucose cotransporter type 2 inhibitors have significantly changed nephroprotection strategies in various categories of patients over the past few years. However, there is no data on ...
Pharmacological efficiency of combined eye drug films based on Levofloxacin and Dexpanthenol, and also Dexamethazone and Dexpanthenol in the treatment of infected corneal injury
Volume 7, Issue №4, 2021
Background: When treating infected corneal burns, some patients are not able to comply with the schedule of frequent instillations of drugs, which entails a persistent irreversible decrease ...
The spectrum of pharmacological activity of different groups of natural compounds of laurel leaves and the choice of the optimal extractant for the extraction of essential oil from them
Volume 7, Issue №3, 2021
Background: Laurel noble – Laurus nobilis L., a plant whose leaves are widely used in cooking and are used in folk medicine. L. nobilis L. leaves contain more ...
Correction of hypertensive retinal changes in rats with Semax
Volume 7, Issue №3, 2021
Background: Currently, there are no drugs for the specific treatment of hypertensive retinal changes. The main therapy is for the treatment of a systemic disease – hypertensive ...
Study on the antioxidant capacity of Hibiscus rosa-sinensis decoction in vivo in Mus musculus var. albino
Volume 7, Issue №2, 2021
Background: In humans, many diseases including cancer are associated with the accumulation of free radicals. Antioxidants can scavenge free radicals and minimize those impacts. Therefore, the antioxidants are ...
Pharmacological effect of indolicidin-like peptides on vasoactive substances content in experimental periodontitis
Volume 7, Issue №1, 2021
Background: The anti-inflammatory effect of indolicidin-like peptides, which have a wide range of antimicrobial effects, has been already reported in several studies. The inflammation of the periodontium is ...
Morphofunctional changes in the retina when modeling the glaucoma process in rats
Volume 6, Issue №4, 2020
Background: Neuroprotective approaches are considered to be the most promising among existing modern directions in the development of antiglaucomatous drugs. The aim of the study: The detection of ...
Effects of first-line anti-TB drugs on the level of toxic plasma phospholipids
Volume 6, Issue №4, 2020
Background: The target of any toxic effect of anti-tuberculosis chemotherapy is primarily the cell. Changes in the structure and functions of cells affect the lipid composition of their ...
The final results of the ASSA-II study: the knowledge of therapeutic doctors on the subject of bronchial asthma
Volume 6, Issue №3, 2020
Background: Bronchial asthma (BA) is one of the leading and socially significant diseases of the respiratory system. In recent years, the proportion of this disease has been steadily ...
Investigation of cerebroprotective properties of the drug «Mexidol» on the model of pneumococcal bacterial meningitis in experimental conditions
Volume 6, Issue №3, 2020
Background: Pneumococcal meningitis is a severe infectious disease, which is characterized by high mortality and frequent development of residual neurological damage. Effective cerebroprotection can improve the outcome of ...
Exhaled nitric oxide as a predictor of the effectiveness of basic therapy for bronchial asthma in children
Volume 6, Issue №2, 2020
Background: The article discusses the predictive ability of monitoring nitric oxide in exhaled air relative to the level of control and the likelihood of developing exacerbations of bronchial ...
Modern possibilities of using the release-active drug Tenoten for Children in the clinical practice of autonomic disorders in children
Volume 6, Issue №2, 2020
Background: Among the pathological conditions found in children and adolescents, vegetative disorders occupy one of the leading places. The development of autonomic dysfunction is due to an imbalance ...
A study of neuroprotective properties of the MGLUR4 receptor agonist – ZC64-0001 in comparison with Mexidol
Volume 6, Issue №2, 2020
Background: One of the most common neurodegenerative diseases is Parkinson's disease, which is based on the degeneration of dopaminergic neurons of the substantia nigra. The modern treatment for ...
Pharmacological effects of the combined administration of a small dose of Acetylsalicylic acid and methyldopa in ADMA-like preeclampsia
Volume 6, Issue №1, 2020
Background: Hypertensive disorders, in particular preeclampsia, which accounts for 2 to 8% of the total number of pregnancies in the world, are one of the leading causes of ...
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