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Pharmacology, clinical pharmacology

Correction of ADMA-Induced Preeclampsia with Use of Phosphodiesterase 5 and Selective Inhibitor of Arginase II ZB49-0010.

Volume 1, Issue №4, 2015
Vladimir V. Gureev, Tatyana G. Pokrovskaya, Olga V. Martynova, Mikhail A. Martynov, Oksana Evgenyevna Anciferova, Tatyana Ivanovna Lokteva
Simulation experimental ADMA-like preeclampsia was carried out by administering the rats L-NAME 14 to 20 days of pregnancy. In animals, there was an increase in blood pressure, proteinuria, impaired microcirculation ...

ENDOTHELIO-AND CARDIOPROTECTIVE EFFECTS OF HMG-Co-A REDUCTASE IN ENDOTOKSIN-INDUCING ENDOTELIAL DYSFUNCTION

Volume 1, Issue №4, 2015
Tatiana A. Denisiuk
The use of inhibitors of HMG-Co-A reductase inhibitor Simvastatin, Atorvastatin, Rosuvastatin and nanoparticulated Rosuvastatin on the background modeling of endotoxin-induced pathology through introduction of strain 603 Staphylococcusaureus leads to the ...

THE ROLE OF MITOCHONDRIAL ATP-DEPENDENT POTASSIUM CHANNELS IN THE CARDIOPROTECTIVE EFFECT OF NICORANDIL ON THE MODEL OF CORONARY OCCLUSIVE MYOCARDIAL INFARCTION

Volume 1, Issue №4, 2015
Lyudmila M. Danilenko
The paper presents the results of a study of the antiischemic effectiveness of nicorandil (1,8 mg/kg) on the model of coronary occlusive myocardial infarction in rabbits. The coronary occlusion in ...

PHARMACOLOGICAL PRECONDITIONING WITH NICORANDIL AS A POSSIBILITY OF INCREASING THE STABILITY OF TISSUES OF THE RETINA TO ISCHEMIA IN AN EXPERIMENT

Volume 1, Issue №4, 2015
Anna S. Shabelnikova
In laboratory rats, we formed an ischemic damage by providing mechanical pressure (110 mm Hg) to the anterior chamber for 30 minutes. The experiment has revealed the fact that nicorandil ...

RESEARCH OF BEHAVIOURAL REACTIONS WHEN MODELLING THE TOTAL ISCHEMIA OF THE BRAIN

Volume 1, Issue №4, 2015
Vladimir V. Gureev, Mikhail V. Pokrovskii, Olga V. Martynova, Mikhail A. Martynov, Anastasia Sergeyevna Solgalova, Oleg Vladimirovich Antsiferov
Dependence of psychoneurological deficiency at rats from severity of injury of a brain, on four-vascular model of a total ischemia of a brain is investigated. Results of research prove a ...

Pharmacological correction of immune and metabolic disorders in acute biliary pancreatitis of varying severity

Volume 5, Issue №1, 2019
Pavel K. Mikaelyan, Alexey L. Loktionov, Natalya A. Bystrova, Peter M. Nazarenko
Background: The incidence of acute pancreatitis is up to 40 cases per 100,000 adult population ...

Comparative evaluation of the effectiveness of DMAE derivative 7-16, carbamilated darbepoetin and substance C7070 in correction of hypertensive neuroretinopathy in rats

Volume 5, Issue №1, 2019
Igor I. Lyubimov, Viktoriya O. Gubareva
Background: Increasing the effectiveness of drug therapy for hyperintensive neuroretinopathy is one of the important tasks of pharmacology and ophthalmology. The aim of the study: To assess the effectiveness ...

Research on the expansion of the use of extracts of Rhodiola rosea, Linden cordate and Astragalus aspercentage in clinical practice

Volume 5, Issue №1, 2019
Anna M. Temirbulatova, Eleonora F. Stepanova, Daria V. Veselova, Larisa P. Lezhneva
Background: One of the problems of modern medicine is to ensure the prevention of a number of ...

Pharmacological correction of metabolic disturbances in experimental acute pancreatitis on the background of chronic alcohol intoxication

Volume 4, Issue №4, 2018
Olga N. Bushmina, Alexey L. Loktionov, Svetlana A. Dolgareva, Alexandr I. Konoplya
Background: Acute pancreatitis ranks third among all acute surgical diseases of the abdominal cavity and is one of the important unresolved problems in emergency surgery. The aim of the ...

Development of the composition and analysis of suppositories of antihemorrhoidal action

Volume 4, Issue №4, 2018
Anna Anatolievna Chahirova, Elena V. Kovtun, Marina A. Ogay, Eleonora F. Stepanova, Natalia L. Nam
Background: The study is devoted to the development of composition and assessment of the quality of two-layered suppositories with an oil extract of rowanberries (

Perspective materials for drug delivery in the ophthalmic dosage form: a short review of polymers for electrospinning

Volume 4, Issue №4, 2018
Alexandra V. Baskakova
Background: The traditional ophthalmological dosage forms have a low bioavailability, a rapid precorneal clearance and a low corneal permeability. The gelling system or system with a prolonged action (prolonged ...

APPROACHES TO CORRECTION OF ISCHEMIC AND REPERFUSION KIDNEY INJURIES IN EXPERIMENT

Volume 4, Issue №3, 2018
Vladislav V. Elagin, Oleg I. Bratchikov, Anastasia A. Ulyanova, Larisa Vladimirovna Godovnikova
Background: Acute kidney injury is an urgent health problem at the junction of specialties with a high level of disability and ...

EVALUATION OF ANTIHYPOXIC ACTIVITY OF ETHYLMETHYLHYDROXIPYRIDINE SUKCINATE IN IN VITRO EXPERIMENTS

Volume 4, Issue №3, 2018
Sofya Ya. Skachilova, Alla S. Kotelnikova, Alyona S. Timokhina, Olesya Victorovna Shcheblykina
Background: The search for potential cardio- and cerebroprotective agents among the derivatives of oxypyridine is topical, since they are proven to contain the compounds with antihypoxic, antioxidant activity, and ...

THE PROBLEM OF EXPERIMENTAL MODEL CHOICE IN BIOMEDICAL RESEARCHES OF IMPLANTS (REVIEW)

Volume 4, Issue №3, 2018
Aleksandr Anatolievich Dolzhikov, Irina N. Dolzhikova
Background: Biomedical researches and improvement of methods for medical materials manufacturing with certain properties and their pharmacological support caused the integration of achievements in materials science and medicine and ...
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