Pharmacology
Stress-protective activity of Astragalus physodes extract on the model of «social» stress
Volume 9, Issue №3, 2023
Background: In recent decades, in the conditions of human existence, special attention has been paid to the problem of stress and the body's response to the impact of ...
Effect of pyrimidine derivative on cytokine levels in experimental generalized staphylococcal infection
Volume 9, Issue №3, 2023
Background: To date, bacterial infections caused by microorganisms characterized by antibiotic resistance are one of the leading causes of the protracted course of infectious and inflammatory diseases that ...
Effectsofcomplexphytoadaptogensinmatobolicsyndrome
Volume 9, Issue №2, 2023
Background: The widespread prevalence of metabolic syndrome (MS) is becoming a serious problem for the population around the world, increasing the risk of developing type 2 diabetes ...
Pharmacological potential of ar-turmerone and study of the extractive potential of fluorinated alkane derivatives for its isolation from the rhizomes of Curcuma longa L.
Volume 9, Issue №2, 2023
Background: Ar-turmerone is one of the main components of the essential oil of the rhizomes of Curcuma longa L. It determines the specificity of the composition of the ...
State of colon parietal microbiota and antioxidant properties of colonocytes in rats with ecological dysbiosis treated with sea vitamin E and buckthorn oil
Volume 9, Issue №1, 2023
Background: When the macroorganism is exposed to pesticides, qualitative and/or quantitative changes in the microbiocenosis composition occur – dysbiosis. As a result of this action, lipid peroxidation ...
Pathological conditions associated with tau protein: mechanisms of development and possible biological targets for pharmacological correction of tau proteinopathy (review)
Volume 8, Issue №4, 2022
Background: The pathological process associated with the pathogenic aggregation of tau is called taupathy. The same term is often used to refer to a group of neurodegenerative diseases, ...
The role of cortisol metabolism in the realization of pathogenetic links in the development of osteoporosis – the rationale for the search for new pharmacotherapeutic targets (review)
Volume 8, Issue №4, 2022
Background: Osteoporosis is an important medical and social public health problem in an aging or elderly society. Osteoporosis is caused by an imbalance in bone remodeling, which ...
In silico identification of the potential natural inhibitors of SARS-CoV-2 Guanine-N7 methyltransferase
Volume 8, Issue №3, 2022
Background: The outbreak of the COVID-19 pandemic caused by the SARS-CoV-2 has triggered intense scientific research into the possible therapeutic strategies that can combat the ravaging disease. One ...
Correction of mitochondrial dysfunction with cinnamic acids in experimental hypercytokinemia
Volume 8, Issue №3, 2022
Background: Mitochondrial dysfunction is an essential component of the hypercytokine neurotoxicity pathogenesis and is a promising pharmacotherapeutic target. The aim of the study: To evaluate the effect of ...
Studies to elucidate the effect and antiapoptotic mechanism of 2-ethyl-3-hydroxy-6-methylpyridine-n-acetyltaurinate in a rat model of retinal ischemia–reperfusion
Volume 8, Issue №3, 2022
Background: The study of possible ways of effective correction of retinal ischemia-reperfusion injury, which accompanies a number of eye diseases, is relevant today. The aim of the ...
Pharmacological characteristics of intranasal dosage forms containing Ginkgo biloba extracts
Volume 8, Issue №2, 2022
Background: This article reviews the pharmacological characteristics of developed dosage forms for intranasal administration. The influence of the type of dosage form on the efficacy of the ...
Status of the glutathione antioxidant defense in fungicide intoxication and correction with vitamin A and milk thistle
Volume 8, Issue №2, 2022
Background: Thiram entering with food products into tissues and organs of animals and humans can lead to the activation of free-radical oxidation processes and, as a consequence, ...
Wound healing effect of organometallic zinc complex in the rat model of planar skin wound
Volume 8, Issue №1, 2022
Background: The complex and dynamic process of wound healing involves the stages of inflammation, proliferation and maturation of the connective tissue of the scar. Zinc, as an essential ...
Effect of sodium-glucose cotransporter type 2 inhibitors on the dynamics of functional and structural disorders in the simulation of post-contrast acute kidney injury
Volume 8, Issue №1, 2022
Background: Sodium-glucose cotransporter type 2 inhibitors have significantly changed nephroprotection strategies in various categories of patients over the past few years. However, there is no data on ...
Pharmacological efficiency of combined eye drug films based on Levofloxacin and Dexpanthenol, and also Dexamethazone and Dexpanthenol in the treatment of infected corneal injury
Volume 7, Issue №4, 2021
Background: When treating infected corneal burns, some patients are not able to comply with the schedule of frequent instillations of drugs, which entails a persistent irreversible decrease ...
The spectrum of pharmacological activity of different groups of natural compounds of laurel leaves and the choice of the optimal extractant for the extraction of essential oil from them
Volume 7, Issue №3, 2021
Background: Laurel noble – Laurus nobilis L., a plant whose leaves are widely used in cooking and are used in folk medicine. L. nobilis L. leaves contain more ...
Correction of hypertensive retinal changes in rats with Semax
Volume 7, Issue №3, 2021
Background: Currently, there are no drugs for the specific treatment of hypertensive retinal changes. The main therapy is for the treatment of a systemic disease – hypertensive ...
Study on the antioxidant capacity of Hibiscus rosa-sinensis decoction in vivo in Mus musculus var. albino
Volume 7, Issue №2, 2021
Background: In humans, many diseases including cancer are associated with the accumulation of free radicals. Antioxidants can scavenge free radicals and minimize those impacts. Therefore, the antioxidants are ...
Pharmacological effect of indolicidin-like peptides on vasoactive substances content in experimental periodontitis
Volume 7, Issue №1, 2021
Background: The anti-inflammatory effect of indolicidin-like peptides, which have a wide range of antimicrobial effects, has been already reported in several studies. The inflammation of the periodontium is ...
Morphofunctional changes in the retina when modeling the glaucoma process in rats
Volume 6, Issue №4, 2020
Background: Neuroprotective approaches are considered to be the most promising among existing modern directions in the development of antiglaucomatous drugs. The aim of the study: The detection of ...
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