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Pharmacology

Correction of mitochondrial dysfunction with cinnamic acids in experimental hypercytokinemia

Volume 8, Issue №3, 2022
Background: Mitochondrial dysfunction is an essential component of the hypercytokine neurotoxicity pathogenesis and is a promising pharmacotherapeutic target. The aim of the study: To evaluate the effect of ...

Effect of sodium-glucose cotransporter type 2 inhibitors on the dynamics of functional and structural disorders in the simulation of post-contrast acute kidney injury
 

Volume 8, Issue №1, 2022
Background: Sodium-glucose cotransporter type 2 inhibitors have significantly changed nephroprotection strategies in various categories of patients over the past few years. However, there is no data on ...

Correction of hypertensive retinal changes in rats with Semax

Volume 7, Issue №3, 2021
Background: Currently, there are no drugs for the specific treatment of hypertensive retinal changes. The main therapy is for the treatment of a systemic disease – hypertensive ...

Study on the antioxidant capacity of Hibiscus rosa-sinensis decoction in vivo in Mus musculus var. albino
 

Volume 7, Issue №2, 2021
Background: In humans, many diseases including cancer are associated with the accumulation of free radicals. Antioxidants can scavenge free radicals and minimize those impacts. Therefore, the antioxidants are ...

Pharmacological effect of indolicidin-like peptides on vasoactive substances content in experimental periodontitis

Volume 7, Issue №1, 2021
Background: The anti-inflammatory effect of indolicidin-like peptides, which have a wide range of antimicrobial effects, has been already reported in several studies. The inflammation of the periodontium is ...

Morphofunctional changes in the retina when modeling the glaucoma process in rats
 

Volume 6, Issue №4, 2020
Background: Neuroprotective approaches are considered to be the most promising among existing modern directions in the development of antiglaucomatous drugs. The aim of the study: The detection of ...

Effects of first-line anti-TB drugs on the level of toxic plasma phospholipids
 

Volume 6, Issue №4, 2020
Background: The target of any toxic effect of anti-tuberculosis chemotherapy is primarily the cell. Changes in the structure and functions of cells affect the lipid composition of their ...

Investigation of cerebroprotective properties of the drug «Mexidol» on the model of pneumococcal bacterial meningitis in experimental conditions

Volume 6, Issue №3, 2020
Background: Pneumococcal meningitis is a severe infectious disease, which is characterized by high mortality and frequent development of residual neurological damage. Effective cerebroprotection can improve the outcome of ...

Exhaled nitric oxide as a predictor of the effectiveness of basic therapy for bronchial asthma in children
 

Volume 6, Issue №2, 2020
Background: The article discusses the predictive ability of monitoring nitric oxide in exhaled air relative to the level of control and the likelihood of developing exacerbations of bronchial ...

Modern possibilities of using the release-active drug Tenoten for Children in the clinical practice of autonomic disorders in children
 

Volume 6, Issue №2, 2020
Background: Among the pathological conditions found in children and adolescents, vegetative disorders occupy one of the leading places. The development of autonomic dysfunction is due to an imbalance ...

A study of neuroprotective properties of the MGLUR4 receptor agonist – ZC64-0001 in comparison with Mexidol
 

Volume 6, Issue №2, 2020
Background: One of the most common neurodegenerative diseases is Parkinson's disease, which is based on the degeneration of dopaminergic neurons of the substantia nigra. The modern treatment for ...
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