Research Results in Biomedicine

Alexandra A. Lebedeva, Alexandra I. Kavun, Ekaterina V. Belova, Tatiana G. Antonova, Anna B. Semenova, Olesya A. Kuznetsova, Tatiana V. Grigoreva, Egor M. Veselovsky, Anastasiia N. Taraskina, Maxim V. Ivanov, Vladislav A. Mileyko, Alexey A. Tryakin, Mikhail Y. Fedyanin, Ilya A. Pokataev, Mariya M. Byakhova, Vsevolod N. Galkin,

Background: Targeting the epidermal growth factor receptor (EGFR) with cetuximab or panitumumab (anti-EGFR MAb) has been historically reserved for patients with RAS/BRAF wild-type advanced colorectal cancer (CRC). However, ...

**Association of polymorphic locus rs4880 of superoxide dismutase 2 gene (SOD2) with Polycystic Ovary Syndrome: A meta-analysis**

Ruba M. Ali, Svetlana V. Lomteva, Anzhela A. Aleksandrova, Manar N.A. Ammar, Igor G. Bulanov, Tatiana P. Shkurat

Background: According to WHO, approximately 8-13% of women of reproductive age suffer from polycystic ovary syndrome (PCOS), while up to 70% of women worldwide with PCOS remain ...

Relationship of transposable elements with non-coding RNAs in the development of atherosclerosis (review)

Rustam N. Mustafin, Elza K. Khusnutdinova

Background: Atherosclerosis is the leading cause of cardiovascular pathology in adults around the world. Association of the disease with age indicates the presence of common mechanisms for ...

Genetic variants of sex hormone-binding globulin and hormonal profile in patients with genital endometriosis

Tatyana A. Ponomareva

Background: Endometriosis is a chronic inflammatory, dyshormonal disease. Genetic factors play an important role in its development. Sex hormone imbalance is important for the occurrence, growth and ...

Characteristics of inter-locus interactions in the development of isolated and combined complications of pregnancy

Oleg V. Golovchenko

Background: Pregnancy complications have a high prevalence and important medical and social implications. Genetic factors are involved in their development. The aim of the study: To study ...

Impact of Aerobic Exercise on Expression of OPN and OPG Genes and Bmal1 Protein in the Bone Tissue of Diabetic Rats During Two Phases of Light and Dark Circadian Rhythm

Maryam Janbozorgi, Masoumeh Hosseinzadeh, Asma Taheri,, Sahar Ghafaripur

Background: Diabetes is a major global disease with a high mortality rate.The impact of exercise on bone tissue protection in diabetic rats during circadian cycle phases is unknown. ...

Ovarian cancer: the significant of gene methylation in carcinogenesis (review)

Ekaterina A. Andreeva, Elvira T. Mingazheva, Rania R. Faiskhanova, Yana V. Valova, Yulia Yu. Fedorova, Alfiya Kh. Nurgalieva, Dina D. Sakaeva, Elza K. Khusnutdinova, Darya S. Prokofieva

Background: Epigenetic regulation of genes plays an important role in the development of ovarian cancer. One of these mechanisms is DNA methylation of tumor suppressor genes and ...

Unusual chromosomal rearrangements detected by FISH in patients at high genetic risk

Anduriña Barrios-Martínez, Odalys Molina, Michel Soriano-Torres, Pedro Carbonell, Diana Martin-Garcia, Luis A. Méndez-Rosado

Background: Genetic and chromosomal causes in particular are responsible for a large percentage of pregnancy losses during the first trimester of pregnancy. Among chromosomal abnormalities, balanced or ...

Mycobacterium tuberculosis gene variants associated with drug resistance to fluoroquinolones (literature review)

Elizaveta I. Gordeeva, Pavel N. Filippov, Natalia V. Tursunova, Alexey V. Salmin

Background: The spread of M. tuberculosis drug resistance to fluoroquinolones poses a threat to their long-term clinical efficacy. Understanding the mechanisms of formation of drug resistance to ...

Assessment of the relationship between marriage and migration characteristics of the population of the Belgorod region in dynamics over 130 years

Kristina N. Sergeeva, Inna N. Sorokina

Background: The importance of studying the dynamics of the population-demographic structure of the population of the south of Central Russia over several generations dictates the need to ...

Geno-phenotypic features of cystic fibrosis in Russian children from the Chechen and Karachay-Cherkess Republics

Maxim V. Simonov, Yulia V. Gorinova, Olga I. Simonova, Alexander A. Pushkov, Ilya S. Zhanin, Alina Y. Alekseeva, Dmitry S. Demyanov, Aliy Y. Asanov, Kirill V. Savostyanov

Background: Cystic fibrosis (CF) is an autosomal recessive disease that occurs with a frequency of 1:1,500 to 1:5,000 newborns, according to the World Health Organization. In the ...

**Relationship between polymorphism rs1546155 of the GGT7 gene and the risk of ischemic stroke**

Elena L. Drozdova, Galina V. Komkova, Anna A. Polonikova, Michail I. Churilin, Maria A. Solodilova

Background: Since oxidative stress plays a role in the pathogenesis of ischemic stroke (IS), it is important to investigate the molecular mechanisms contributing to redox homeostasis and ...

Circulating platelet-derived microRNAs as potential biomarkers of STEMI in patients with hypertension

Andrey V. Zhelankin, Daria A. Stonogina, Anna S. Akselrod

Background: Circulating extracellular platelet-derived microRNAs have been actively studied over the last decade as promising biomarkers of cardiovascular disease (CVD), since platelet activation plays a key role ...

Polymorphism in the matrix metallopeptidase genes is associated with coronary artery disease risk with concomitant metabolic syndrome

Anastasia V. Ponasenko, Anna V. Sinitskaya, Maria V. Khutornaya, Maxim Yu. Sinitsky, Maxim A. Asanov, Alena O. Poddubnyak

Background: Metabolic syndrome (MS) and its components are the reasons of the development and progression of cardiovascular diseases. Nowadays, the association between coronary artery disease and MS ...

Genetic variant **rs11568818 of matrix metalloproteinase MMP7 associated with newborn weight in pregnant women with fetal growth restriction**

Yuliya N. Reshetnikova, Irina V. Ponomarenko, Vladimir I. Churnosov, Marina S. Ponomarenko, Evgeny A. Reshetnikov

Background: Fetal growth restriction is a common complication of pregnancy that has been associated with a variety of adverse perinatal outcomes. The condition carries significant risks of ...

HSPD1 gene polymorphism is associated with an increased risk of ischemic stroke in smokers

Tatiana A. Stetskaya, Ksenia A. Kobzeva, Sergey M. Zaytsev, Irina V. Shilenok, Galina V. Komkova, Natalia V. Goryainova, Olga Yu. Bushueva

Background: Ischemic stroke (IS) is a leading cause of death and disability worldwide. Since the influence of vascular stressors prompts cross-reactivity with microbial and human HSPD1 (HSP60), which ...

Search for molecular markers of joint hypermobility