Effect of sodium-glucose cotransporter type 2 inhibitors on the dynamics of functional and structural disorders in the simulation of post-contrast acute kidney injury
Background: Sodium-glucose cotransporter type 2 inhibitors have significantly changed nephroprotection strategies in various categories of patients over the past few years. However, there is no data on their effect on the course of post-contrast kidney injury. The aim of the study:To study the effect of sodium-glucose cotransporter type 2 inhibitors on the dynamics of morphological and functional parameters in the simulation of post-contrast acute kidney injury. Materials and methods: The experiment was carried out on 50 male Wistar rats. Post-contrast acute kidney injury simulation was carried out by sequential administration of a cyclooxygenase inhibitor, a blocker of nitric oxide synthases, and iohexol. The administration of sodium-glucose cotransporter inhibitors was carried out before modeling post-contrast acute kidney injury: dapagliflozin at a dose of 1 mg/kg, canagliflozin – 25.7 mg/kg, empagliflozin – 2 mg/kg, taking into account their pharmacokinetics. Renoprotective effects were assessed after 48 hours by the combination of functional (glomerular filtration rate and serum creatinine concentration) and structural (descriptive morphology and scoring of impairment severity) changes in the kidneys. Results: Pretreatment with dapagliflozin, canagliflozin and empagliflozin against the background of postcontrast acute kidney injury led to statistically significant changes in the following parameters: serum creatinine concentration and glomerular filtration rate. Improvement in the pathological picture in combination with a decrease in the score for the epithelial, glomerular, interstitial and endothelial damage severity degree, also confirmed the protective effects of the sodium-glucose cotransporter inhibitors. Conclusion: The results of the study demonstrate a high renoprotective potential of type 2 sodium-glucose cotransporter inhibitors: dapagliflozin, canagliflozin, and empagliflozin in a model of post-contrast acute kidney injury with a single preliminary administration
Poltev VYu, Kostina DA, Nesterova NI, et al. Effect of sodium-glucose cotransporter type 2 inhibitors on the dynamics of functional and structural disorders in the simulation of post-contrast acute kidney injury. Research Results in Biomedicine. 2022;8(1):56-70. Russian. DOI:
10.18413/2658-6533-2022-8-1-0-4
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